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Lenski, Richard E. and Judith E. Bouma. 1987. Effects of Segregation and Selection on Instability of Plasmid pACYC184 in Escherichia coli B. EPA/600/J-87/311. J. Bacteriol. 169(11):5314-5316. (ERL,GB X557). (Avail. from NTIS, Springfield, VA: PB88-196241)

We use a mathematical model to analyze the dynamics of loss of nonconjugative pACYC184 from populations of Escherichia coli B in glucose-limited continuous culture. This model incorporates both plasmid segregation and selection against plasmid carriage. It is concluded that there is intense selection against plasmid carriage (s=0.3 per culture generation), which amplifies the frequency of segregants arising de novo.

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