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Substitute Sterilants

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Note: SNAP Notices and Final Rules published in the Federal Register take precedence over all information on the web site.
Acceptable Substitutes for the 12/88 Blend of Ethylene Oxide (EtO) and CFC-12
Substitute Comments
CO2 / EtO CO2/EtO blends can serve as drop-in replacements to 12/88 in some but not in all existing equipment because they require a higher operating pressure. As a HAP, use of EtO must comply with Title III of the CAA. This agent is FIFRA registered.
HCFC-124 / EtO HCFC-124 is an ozone depleting substance; it should be used to sterilize only equipment that cannot be sterilized using other alternatives such as steam or CO2/EtO blends. As a HAP, use of EtO must comply with Title III of the CAA. This agent is FIFRA registered.
[HCFC Blend] A / EtO This blend contains HCFC-124, an ozone depleting substance; it should be use to sterilize only equipment that cannot be sterilized using other alternatives such as steam or CO2/EtO blends. As a HAP, use of EtO must comply with Title III of the CAA. This agent is FIFRA Registered.
IoGas™ Sterilant Blend 1 (blend of CF 3I/CO2/EtO) As a HAP, use of EtO must comply with Title III of the CAA. FIFRA registration of this agent is pending.
IoGas™ Sterilant Blend 3 (blend of CF 3I/CO2/EtO) As a HAP, use of EtO must comply with Title III of the CAA. FIFRA registration of this agent is pending.
IoGas™ Sterilant Blend 6 (blend of CF 3I/CO2/EtO) As a HAP, use of EtO must comply with Title III of the CAA. FIFRA registration of this agent is pending.
Pure EtO EtO is a toxic, carcinogenic substance and is considered a hazardous air pollutant. Potential exposures of the general population to EtO releases can be limited either through the use of catalytic converters which convert waste EtO into CO2 and water, or through the use of acid water scrubbers which convert waste EtO into ethylene glycol. Must be used in accordance with manufacturer recommendations to address flammability concerns. Must be used in accordance with OSHA standards to limit occupational exposures. As a HAP, use of EtO must comply with Title III of the CAA.
Peroxyacetic Acid / Hydrogen Peroxide Gas Plasma Systems None
Hydrogen Peroxide Gas Plasma Systems None
Steam Applicable only to devices resistant to heat and moisture.
The Mini-Max Cleaner® None


Acceptable Substitutes for Blends of Ethylene Oxide (EtO) and HCFCs (Class II ODS) as Sterilants
Substitute HCFC-Containing Blends Replaced Comments
IoGas™ Sterilant Blend 1 (blend of CF 3I/CO2/EtO) HCFC-124/EtO; HCFC Blend A (HCFC-124 and HCFC-22)/EtO As a HAP, use of EtO must comply with Title III of the CAA. FIFRA registration of this agent is pending.
IoGas™ Sterilant Blend 3 (blend of CF 3I/CO2/EtO) HCFC-124/EtO; HCFC Blend A (HCFC-124 and HCFC-22)/EtO As a HAP, use of EtO must comply with Title III of the CAA. FIFRA registration of this agent is pending.
IoGas™ Sterilant Blend 6 (blend of CF 3I/CO2/EtO) HCFC-124/EtO; HCFC Blend A (HCFC-124 and HCFC-22)/EtO As a HAP, use of EtO must comply with Title III of the CAA. FIFRA registration of this agent is pending.
The Mini-Max Cleaner® HCFC-124/EtO; HCFC Blend A (HCFC-124 and HCFC-22)/EtO None.
CO2/EtO Blends of EtO containing HCFC-22 CO2/EtO blends can serve as drop-in replacements to 12/88 in some but not in all existing equipment because they require a higher operating pressure.  As a HAP, use of EtO must comply with Title III of the CAA. This agent is FIFRA registered.
Pure EtO Blends of EtO containing HCFC-22 EtO is a toxic, carcinogenic substance and is considered a hazardous air pollutant. Potential exposures of the general population to EtO releases can be limited either through the use of catalytic converters which convert waste EtO into CO2 and water, or through the use of acid water scrubbers which convert waste EtO into ethylene glycol. Must be used in accordance with manufacturer recommendations to address flammability concerns. Must be used in accordance with OSHA standards to limit occupational exposures. As a HAP, use of EtO must comply with Title III of the CAA. This agent is FIFRA registered.
Peroxyacetic Acid/Hydrogen Peroxide Gas Plasma Systems Blends of EtO containing HCFC-22 This agent is FIFRA registered.
Hydrogen Peroxide Gas Plasma Systems Blends of EtO containing HCFC-22 This agent is FIFRA registered.
Steam Blends of EtO containing HCFC-22 Applicable only to devices resistant to heat and moisture.

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