John F. Kenneke
My research focuses on developing innovative approaches for elucidating the absorption, distribution, metabolism and elimination (ADME) of xenobiotics in organisms, and applying experimental results to understanding and modeling chemical exposure for informing human health and ecological risk assessment. I utilize in vitro and in vivo systems from a variety of invertebrate and vertebrate species, including human, to measure xenobiotic metabolic maps, biotransformation kinetics, biotransformation mechanisms and stereo specific metabolism. These results are used to develop physiological based pharmacokinetic models for predicting dose as a function of exposure concentration, and to extrapolate between species, routes of exposure, and from high-to-low exposure levels. These tools directly apply to prioritizing chemicals for hazard testing and managing chemical risk.
Biographical Information
Name: John F. Kenneke
Title: Research Chemist
Contact Information:
Ecosystems Research Division
National Exposure Research Laboratory
Office of Research and Development
U.S. Environmental Protection Agency
960 College Station Road
Athens, Georgia 30605-2700
Phone: 706-355-8247
Email:
kenneke.john@epa.gov
Education
Ph.D. Environmental Chemistry, University of North Carolina, Chapel Hill, 1996
M.S. Organic Chemistry, University of Illinois, Urbana-Champaign, 1989
B.S. Chemistry and Biology, Iowa State University, 1987
Professional Experience
Research Chemist, USEPA, ORD, NERL-ERD, Athens, GA 1998-present
NRC Research Associate, USEPA, ORD, NERL-ERD, Athens, GA 1996-1998
Visiting Researcher, University of Kuopio, Finland 1995; 1997
Chemist, Triangle Laboratories, Durham, NC 1990; 1995-1996
Research Assistant, University of North Carolina, Chapel Hill, NC 1990-1995
Research/Teaching Assistant, University of North Carolina, Chapel Hill, NC 1989-1990
Analytical Chemist, Allied-Signal/Union Carbide/UOP, Des Plaines, IL 1985-1987; 1989
Research/Teaching Assistant, University of Illinois, Urbana-Champaign, IL 1987-1989
Professional Affiliations
American Chemical Society
Division of Environmental Chemistry, American Chemical Society
Selected Awards and Honors
USEPA, ORD Science Communication Award, 2009
USEPA, STAA Award, Honorable Mention, 2008, 2004
USEPA, NERL Special Achievement Award for Quality Assurance, 2006
USEPA, Commendation by Acting Assistant Administrator for outstanding work on the technical evaluation panel for the Nuclear Magnetic Resonance (NMR) Spectrometer, 2005
USEPA, ORD Bronze Medal, 2004, 2000
Featured post-doc in NERL Mid-Year Review: Getting to Green, 2002
Selected Invited Lectures/Symposia
Kenneke, J. F.; Mazur, C. S.; Garrison, A. W. 2007. Enantioselective formation of the triazole fungicide triadimenol from triadimefon in mammal and fish hepatic microsomes. American Chemical Society, 234th National Convention, Division of Agrochemicals, August 19-23, Boston, MA
Kenneke, J.F. and C.S. Mazur. 2006. In Vitro Metabolism Research at NERL/ERD: An Overview of the Conazole Fungicides. U.S. EPA, NHEERL & NERL Metabolism Meeting. RTP, NC
Kenneke, J.F., C.S. Mazur and A.W. Garrison, 2005. In vitro Phase 1 Metabolism of the Triazole Fungicide Bromuconazole and Its Four Enantiomers. American Chemical Society, 230th National Convention, Division of Agrochemicals, Washington, D.C.
Mekenyan, O., J. Kenneke, P. Winget, K. Wolfe, J. Jones and M. Long. 2005. Cooperative Development of a Searchable Metabolism Database (MetaPath), U.S. EPA, OPP, Scientist-to-Scientist Meeting, Washington, D.C.
Kenneke, J.F. and D.R. Ekman, 2004. ORD’s Computational Toxicology Program and Metabonomics. Imperial College, London, UK
Kenneke. J.F. 2004. Summary of Modeling Tools for Forcasting Transformations of Organic Chemicals in Water, U.S. EPA ,OPPTS, Drinking Water Scientist-to-Scientist Meeting, Washington, D.C.