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2005 Board of Scientific Counselors Computational Toxicology Review

Note: EPA no longer updates this information, but it may be useful as a reference or resource.


The Board of Scientific Counselors (BOSC) was established by the U.S. Environmental Protection Agency (EPA) to provide advice, information, and recommendations about the Office of Research and Development (ORD) research program. The mission of the BOSC is to provide advice and recommendations on:

  • Evaluating science and engineering research, programs and plans, laboratories, and research-management practices of ORD and recommending actions to improve their quality and/or strengthen their relevance to EPA's mission.
  • Evaluating and providing advice concerning the utilization of peer review within ORD to sustain and enhance the quality of science in EPA.
  • Reviewing ORD's program development and progress, ORD's research planning process, and research program balance, including implementation of the ORD Strategic Plan.
  • Providing peer review including evaluation of ORD's peer review policies, and reviewing ORD Offices, National Laboratories and Centers, and research plans and products.
  • Providing advice on human resources planning, such as scientist career development and rotational assignment programs, and the appropriate scope and design of training programs for environmental research professionals.

Because the BOSC is a Federal Advisory Committee, it must comply with the Federal Advisory Committee Act (FACA) (5 U.S.C. App. C) and related regulations. Consequently, the Board has an approved charter, which must be renewed biennially, announces its meetings in the Federal Register, opens its meetings to the public, and provides opportunities for public comment on issues before the Board.

The BOSC Executive Committee, which includes 15 members, meets three to five times each year. The meetings are held approximately once every 3 months, or an needed and approved by the Designated Federal Officer (DFO). With the approval of EPA, the BOSC Executive Committee establishes subcommittees or workgroups for any purpose consistent with the BOSC's charter. Such subcommittees or workgroups may not work independently of the chartered Executive Committee, and must report their recommendations and advice to the BOSC for full deliberation and discussion. Subcommittees and workgroups have no authority to make decisions on behalf of the BOSC, nor can they report directly to EPA.

Members of the BOSC Executive Committee and Subcommittees constitute a distinguished body of scientists and engineers who are recognized experts in their respective fields. These individuals are drawn from academia, industry, and environmental communities.


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Monday, April 25, 2005

10:00 a.m. - 10:30 a.m. Registration  
10:30 a.m. - 10:45 a.m. Welcomes & Introductions Dr. George Daston, Subcommittee Chair
  DFO Remarks Lori Kowalski, ORD
10:45 a.m. - 11:00 a.m. AA / ORD Remarks (pdf, 10 pp, 337 kb) Mr. Lek Kadeli, Acting DAA, ORD
11:00 a.m. - 12:15 a.m. Background and Direction of ORD's National Center for Computational Toxicology (pdf, 43 pp, 1823 kb) Dr. Robert Kavlock, Director, NCCT
  Interactions of the NCCT (pdf, 17 pp, 290 kb) Dr. Jerry Blancato, Deputy Director, NCCT
12:15 p.m. - 1:15 p.m. Lunch*  
1:15 p.m. - 2:15 p.m. Summary of FY04 ORD Computational (pdf, 51 pp, 2529 kb) Dr. Robert Kavlock, Toxicology Activities Director, NCCT
2:15 p.m. - 2:45 p.m. Discussion Computational Toxicology Subcommittee
2:45 p.m. - 3:45 p.m. Research Theme I: Information (pdf, 49 pp, 1741 kb) Dr. Ann Richard, NCCT Technology
3:45 p.m.- 4:15 p.m. Break*  
4:15 p.m. - 5:15 p.m. Research Theme II:Prioritization
Part A (pdf, 21 pp, 343 kb) and
Part B (pdf, 9 pp, 460 kb)
Dr. James Rabinowitz, NCCT
Dr. Robert Kavlock Director, NCCT
5:15 p.m. - 5:30 p.m. Review of Day 1 Activities Dr. George Daston, Subcommittee Chair
5:30 p.m. Adjourn  

Tuesday, April 26, 2005

8:30 a.m. - 9:30 a.m. Research Theme III: Biological Models (pdf, 35 pp, 1260 kb) Dr. Michael Zager, UNC
Dr. Woody Setzer, NCCT
Dr. Hugh Barton, NCCT
9:30 a.m. - 10:30 a.m. Research Theme IV: Cumulative Risk (pdf, 44 pp, 965 kb) Dr. Elaine CohenHubal, NCCT
Dr. Woodrow Setzer, NCCT
Dr. James Rabinowitz, NCCT
10:30 a.m. - 10:45 a.m. Public Comment  
10:45 a.m. - 11:00 a.m. Break*  
11:00 a.m. - 12:00 p.m. Discussion
- Highlights from posters
- General
Computational Toxicology Subcommittee
12:00 p.m. - 12:30 p.m. Future Business
- Action Items
- Letter Report
- Next Meeting
Dr. George Daston, Subcommittee Chair
12:30 p.m. Adjourn  

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