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2007 CompTox Forum

Poster Presentations: Biological Models

Deposition of Nano- and Micron-sized Fibers in the Alveolar Region of the Human Lung (PDF, 7KB, 1pp)
Contact: Bahman Asgharian, CIIT Centers for Health Research
Poster (PDF, 112KB, 1pp)
Prostate Regulation: Modeling Endogenous Androgens and Exogenous Antiandrogens (PDF, 17KB, 1pp)
Contact: Hugh Barton, U.S. EPA/Office of Research and Development (ORD)/National Center for Computational Toxicology (NCCT)
Poster (PPT, 2.5MB, 1pp)
Mechanistic Computational Model of Steroidogenesis in H295R Cells: Predicting Biochemical Response to Endocrine Active Chemicals (PDF, 16KB, 1pp)
Contact: Michael Breen, U.S. EPA/Office of Research and Development (ORD)/National Center for Computational Toxicology (NCCT)
Poster (PDF, 224KB, 1pp)
Quantitative Modeling Approaches to Predicting the Acute Neurotoxicity of Volatile Organic Compounds (VOCs) (PDF, 15KB, 1pp)
Contact: Phil Bushnell, U.S. EPA/Office of Research and Development (ORD)/National Health and Environmental Effects Research Laboratory (NHEERL)/Neurotoxicology Division (NTD)
Poster (PDF, 212KB, 1pp)
Integration of Animal and Human Gene Expression Data to Improve the Predictive Value of Exposure, Effects, and Susceptibility Biomarkers in Asthmatic Children (PDF, 16KB, 1pp)
Contact: Jane Gallagher, U.S. EPA/Office of Research and Development (ORD)/National Health and Environmental Effects Research Laboratory (NHEERL)
Ozone Uptake in the Nasal Passages of the Infant Rhesus Monkey: Predicting Lesion Location with Computational Fluid Dynamics (PDF, 17KB, 2pp)
Contact: Guilherme Garcia, The Hamner Institutes for Health Sciences
Environmental Systems Biology Framework for Human Health Risk Analysis (PDF, 17KB, 2pp)
Contact: Panos Georgopoulos, University of Medicine and Dentistry of New Jersey
Considerations for Using PBTK and Benchmark Dose Modeling for Cancer Dose Response of 2-Chloro-1,3-Butadiene (PDF, 15KB, 1pp)
Contact: Matthew Himmelstein, DuPont Haskell Laboratory
Exploring Enzyme Induction Using a Physiologically Based, Synthetic Model of Hepatic Lobules (PDF, 14KB, 1pp)
Contact: C. Anthony Hunt, University of California
Prediction of In Vitro Hepatic Biliary Excretion Using Stochastic Agent-Based Modeling and Fuzzy Clustering (PDF, 15KB, 1pp)
Contact: C. Anthony Hunt, University of California
Statistical Modeling of Hormone Removal in Conventional Wastewater Treatment and the Effect of Effluent Hormone Levels on Fathead Minnows (PDF, 12KB, 1pp)
Contact: Tina Hunter, University of Cincinnati/U.S. EPA
Modular Application of Computational Models of Inhaled Reactive Gas Dosimetry for Risk Assessment of Respiratory Tract Toxicity: Chlorine (PDF, 17KB, 2pp)
Contact: Annie Jarabek, U.S. EPA/Office of Research and Development (ORD)/National Center for Environmental Assessment (NCEA)/Immediate Office (IO) and National Health and Environmental Effects Research Laboratory (NHEERL)/Experimental Toxicology Division (ETD)
Application of Advanced In Vitro Techniques to Measure, Understand and Predict the Kinetics and Mechanisms of Xenobiotic Metabolism (PDF, 17KB, 1pp)
Contact: John Kenneke, U.S. EPA/Office of Research and Development (ORD)/National Exposure Research Laboratory (NERL)
The Impact of Structural Uncertainty on the Characterization of Population Heterogeneity Using Toxicokinetic Models of Inhalation Exposure to 1,3-Butadiene (PDF, 15KB, 1pp)
Contact: David Kim, Harvard School of Public Health
Nasal Dosimetry in Childhood: Construction of Anatomically-Accurate Models (PDF, 15KB, 1pp)
Contact: Julia Kimbell, The Hamner Institutes for Health Sciences
Computational Systems Biology: Modeling Developmental Toxicology (PDF, 13KB, 1pp)
Contact: Thomas Knudsen, University of Louisville
Building Realistic Biologically-based Pharmacokinetic Models for Predicting Susceptibility in Aged Population (PDF, 16KB, 2pp)
Contact: Janice Lee, U.S. EPA
Non-Monotonic Dose Response Relationship in Steroid Hormone Receptor-mediated Gene Expression (PDF, 14KB, 1pp)
Contact: Li Li, The Hamner Institutes for Health Sciences
BBPK Model of the Hypothalamic-Pituitary-Thyroid Axis in Adult Male Rats (PDF, 16KB, 1pp)
Contact: Eva McLanahan, University of Georgia
Effects of Short-Term Model EDC Exposures on the Brain-Pituitary-Gonadal Axis of the Fathead Minnow (PDF, 19KB, 2pp)
Contact: Ed Orlando, Florida Atlantic University
Development of a Systems Biological Model of Neurotoxicity (PDF, 12KB, 1pp)
Contact: Zhen Qi, Emory University
Predicting Age-appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically-based Pharmacokinetic Modeling (PDF, 15KB, 1pp)
Contact: Chester Rodriguez, U.S. EPA/Office of Research and Development (ORD)/National Center for Computational Toxicology (NCCT)
Poster (PDF, 92KB, 1pp)
Toxicogenomics and Biology-based Modeling for Risk Assessment of Chemical Mixtures (PDF, 15KB, 1pp)
Contact: Dimosthenis Sarigiannis, European Commission Joint Research Centre - Institute for Health and Consumer Protection
Mechanistically Consistent PBTK Modeling Framework for Mixtures of Toxic Metals (PDF, 15KB, 1pp)
Contact: Alan Sasso, Environmental and Occupational Health Sciences Institute
Nasal Dosimetry of Inhaled Acrolein Using Computational Fluid Dynamics Models (PDF, 13KB, 1pp)
Contact: Jeffry Schroeter, The Hamner Institutes for Health Sciences
NCER-Supported STAR Research on Computational Toxicology (PDF, 13KB, 1pp)
Contact: Deborah Segal, U.S. EPA/Office of Research and Development (ORD)/National Center for Environmental Research (NCER)
Dose-response Modeling for Risk Assessment of Inhaled Acetaldehyde Exposure (PDF, 15KB, 1pp)
Contact: Cecilia Tan, The Hamner Institutes for Health Sciences
Assessing Uncertainty in the Toxicology of PFOA (PDF, 15KB, 1pp)
Contact: John Wambaugh, U.S. EPA/Office of Research and Development (ORD)/National Center for Computational Toxicology (NCCT)
Poster (PDF, 110KB, 1pp)
Urinary Levels of Phthalate Metabolites in Human Populations (PDF, 12KB, 1pp)
Contact: Richard Wang, Centers for Disease Control and Prevention (CDC)
Good Fit or Good Modeling - A Discussion of an Application of Bayesian Methods for Biological Modeling (PDF, 14KB, 1pp)
Contact: Yuching Yang, The Hamner Institutes for Health Sciences, Center for Human Health Assessment (CIIT)
Control Theory and Dose Response Transition in Anti-Stress Gene Regulatory Networks (PDF, 15KB, 1pp)
Contact: Qiang Zhang, The Hamner Institute, CIIT Centers for Health Research
Development of a Biologically Based Dose Response (BBDR) Model for Arsenic Induced Cancer (PDF, 13KB, 1pp)
Contact: Yuchao Zhao, U.S. EPA
Poster (PDF, 68KB, 1pp)

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