International Workshop on Uncertainty and Variability in Physiologically Based Pharmacokinetic (PBPK) Models
Meeting Agenda
TUESDAY, OCTOBER 31 (Day 1 - morning)
| 8:00 - 9:00 am | Registration | Auditorium Entrance | |
| Plenary Session | Auditorium A & B (C111 A & B) | ||
| 9:00 - 9:10 | Welcome | Weihsueh Chiu | |
| 9:10 - 9:30 | Getting Serious About Uncertainty and Variability | George Gray US EPA | |
| 9:30 - 10:00 | Overview of PBPK Modeling and Its Value in Risk Assessment Download presentation (PDF, 26 pp., 310 KB) | Harvey J. Clewell, III CIIT | |
| 10:00 - 10:30 | Experimental Data Used with PBPK Models Download presentation (PDF, 21 pp.,368 KB) | Hugh A. Barton US EPA | |
| 10:30 - 11:00 | BREAK | ||
| 11:00 - 11:30 | Mediating the Meeting between Model and Data: Statistical Issues for PBPK Modeling Download presentation (PDF, 21 pp., 612 KB) | R. Woodrow Setzer US EPA | |
| 11:30 - Noon | Uncertainty and variability in PBPK models: How do we put it all together for risk assessment? Download presentation (PDF, 24 pp., 513 KB) | Weihsueh Chiu US EPA | |
| Noon | What's Next? | R. Woodrow Setzer | |
| Noon - 1:00 pm | LUNCH |
TUESDAY, OCTOBER 31 (Day 1 - afternoon)
| Breakout | Groups | ||
| Group 1: Model Specification | Chairs: Hugh Barton Sean Hays Rapporteur: Bob MacPhail | C113 | |
| Group 2A: Model Calibration | Chair: Woody Setzer Rapporteur: John Bailer | Auditorium A (C111A) | |
| Group 2B: Model Calibration | Chair: Chris Portier Rapporteur: Rob DeWoskin | Auditorium B (C111B) | |
| Group 3: Model Predictions | Chair: Rory Conolly Rapporteur: Weihsueh Chiu | Auditorium C (C111C) | |
| Breakout Groups | |||
| 1:00 - 2:00 pm | Group 1: Data from controlled human exposure as basis for PBPK modeling of variability Download presentation (PDF, 29 pp., 500 KB) | Gunnar Johanson Karolinska Institute | C113 |
| Discrepancies and Discovery: The Value of PBPK Modeling for Insuring Humility Download presentation (PDF, 28 pp., 664 KB) | Melvin Andersen CIIT | ||
| Group 2A&B: Calibration Title: Statistical Population Modeling and Analysis of PK Data Download presentation (PDF, 35 pp., 817 KB) | Marie Davidian Dept. Statistics, North Carolina State University | Auditorium A&B (C111A&B) | |
| Group 3: Accounting for Uncertainty and Variability in PBPK Modeling Predictions:
Where are We Now, Where should We Go? Download presentation (PDF, 12 pp., 84 KB) | Frédéric Bois INERIS (Institut National de L'Environnement Industriel et des Risques). | Auditorium C (C111C) | |
| 2:00 - 3:00 | Comments on White Papers by Invited Participants | Each Breakout Group | |
| 3:00 - 3:30 | BREAK | ||
| 3:30 - 5:00 | Charge Question Discussions | Each Breakout Group |
WEDNESDAY, NOVEMBER 1 (Day 2)
| 8:00 - 10:30 | Charge Question Discussions | Each Breakout Group | |
| 10:30 - 11:00 | BREAK | ||
| 11:00 - 12:30 | Plenary: Report Outs From Breakout Groups | Rapporteurs (15 min each + 5 for questions) | Auditorium A & B (C111 A & B) |
| 12:30 - 1:30 | LUNCH | ||
| 1:30 - 3:30 | Charge Question Discussions | Each Breakout Group | |
| 3:30 - 4:00 | BREAK | ||
| 4:00 - 5:00 | Tours of EPA Facility (Limited to 30 people) | Auditorium Lobby (sign-up required) | |
| 4:00 - 5:00 | Breakout Chairs, Rappoteurs Prepare Report Outs for Day 3 |
THURSDAY, NOVEMBER 2 (Day 3)
| 8:00 - 10:00 am | Breakout Group Report Outs Download Group 1 Report (PDF, 12 pp., 164 KB) Download Group 2a Report (PDF, 12 pp., 230 KB) Download Group 2b Report (PDF, 13 pp., 77 KB) Download Group 3 Report (PDF, 28 pp., 53 KB) | Rapporteurs (20 min each + 10 for questions) | Auditorium A & B (C111 A & B) |
| 10:00 - 10:30 | BREAK | ||
| 10:30 - 12:00 | Plenary Discussion: Next Steps | Auditorium A & B (C111 A & B) |