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sum_text[2]='
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Display Details</title\
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<span style="position:absolute;left:594px;top:0px;width:188px;text-align:center">Output Options</span\
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><span>Details</span\
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><tr\
><th style="width:90px;">Query</th\
><th style="width:120px;">Results Type</th\
><th style="width:60px;">Hits</th\
><th style="width:80px;">Display</th\
><th style="width:150px;"> </th\
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><div style="position:absolute;top:200px;left:183px;"><i>Click <img src="http://epa.gov/dsstox03/corner_button.gif"/> to submit displayed structure for structure search.</i></div\
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<tr>\
<th style="vertical-align:bottom;width:60px;"> <a class="question" href="http://www.epa.gov/ncct/dsstox/StructureBrowserInfo.html#SearchGenericSubstance" target="dsstox_help">?</a> DSSTox<br/>Substance<br/>ID</th>\
<th style="vertical-align:bottom;width:70px;padding:0px;"><a class="question" href="http://www.epa.gov/ncct/dsstox/StructureBrowserInfo.html#Similarity" target="dsstox_help">?</a><br/>Similarity<br/>Score%</th>\
<th style="vertical-align:bottom;width:100px;"> <br/>Structure<br/>Match</th>\
<th style="vertical-align:bottom;width:226px;"> <br/>Substance<br/>Name</th>\
<th style="vertical-align:bottom;width:85px;">CASRN</th>\
<th style="vertical-align:bottom;width:100px;"> <br/>Substance<br/>Description</th>\
<th style="vertical-align:bottom;width:120px;font-weight:normal;"><br/><b>Details</b><br/><a class="hlink" style="padding:0px; font-size:13px;" href="http://www.epa.gov/ncct/dsstox/DataFiles.html" target="dsstox_help">(Data Files)</a></th></tr>\
</table>\
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<div class="detail">\
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top.field_def = new Object();
top.field_def.STRUCTURE = '2D (or 3D) MDL "mol" file representation for defined molecular structure. STRUCTURE_Shown field relates content of STRUCTURE field to actual tested substance and TestSubstance_... fields. Click the ? for more details.';
top.field_def.DSSTox_RID = 'DSSTox Record ID is number uniquely assigned to all DSSTox records across all DSSTox files, regardless of Test Substance characteristics or STRUCTURE field content, i.e. no two DSStox records share a DSSTox_RID. Click the ? for more details.';
top.field_def.DSSTox_CID = 'DSSTox Chemical ID number is uniquely assigned to a particular STRUCTURE and "STRUCTURE-content" fields across all DSSTox data files. Different CID numbers will be assigned if two STRUCTURE records are substantively different, e.g., different chemical, salt or complex form, or stereochemical isomer. Click the ? for more details.';
top.field_def.DSSTox_Generic_SID = 'Records with the same DSSTox_Generic_SID (Generic Substance ID) will share all DSSTox Standard Chemical Fields, including STRUCTURE. Field distinguishes at the level of "Test Substance" across all DSSTox datafiles, most often corresponding to the level of CASRN distinction, but not always. Click the ? for more details.';
top.field_def.DSSTox_FileID = 'Sequential ID number uniquely assigned to each DSSTox data file record, with values ranging from 1 to n, where n=total # of records, followed by an underscore and the abbreviated DSSTox SDF standard file name and version, e.g., 1_CPDBAS_v4a. Field entry provides a unique record identifier for every DSSTox data record. Click the ? for more details.';
top.field_def.STRUCTURE_Formula = 'Empirical formula of displayed STRUCTURE, automatically generated from the STRUCTURE field entry using commercial software (e.g., CambridgeSoft ChemFinder or ACD ChemFolder). Click the ? for more details.';
top.field_def.STRUCTURE_MolecularWeight = 'Molecular weight or molar mass (atomic mass units) of displayed STRUCTURE. Click the ? for more details.';
top.field_def.STRUCTURE_ChemicalType = 'Nature of chemical displayed in STRUCTURE field: defined organic; "inorganic"; "organometallic"; "no structure" indicates STRUCTURE field is blank; used when TestSubstance_Description = "mixture or formulation " or "unspecified or multiple forms". Click the ? for more details.';
top.field_def.STRUCTURE_TestedForm_DefinedOrganic = 'Tested form of chemical displayed in STRUCTURE field; field entry provided only for STRUCTURE_ChemicalType = "defined organic". Click the ? for more details.';
top.field_def.STRUCTURE_Shown = 'Identifies relationship of the graphical structure displayed in the STRUCTURE field to the actual tested chemical substance. Click the ? for more details.';
top.field_def.TestSubstance_ChemicalName = 'Common or trade name of chemical listed in original Source data file. Field entry corresponds to TestSubstance_CASRN. If STRUCTURE_Shown = "tested chemical", field entry corresponds directly to STRUCTURE. Click the ? for more details.';
top.field_def.TestSubstance_CASRN = 'Chemical Abstracts Service (CAS) Registry Number of the tested substance, formatted 000000-00-0. In general, corresponds to TestSubstance_ChemicalName. If STRUCTURE_Shown = "tested chemical", field entry corresponds directly to STRUCTURE. "NOCAS" indicates CAS number was unavailable from original Source data table or was not found. Click the ? for more details.';
top.field_def.TestSubstance_Description = 'Description or chemical nature of test substance: "single chemical compound"; "macromolecule"; "mixture or formulation"; or "unspecified or multiple forms". Click the ? for more details.';
top.field_def.ChemicalNote = 'Note provides additional information related to tested substance.. Click the ? for more details.';
top.field_def.STRUCTURE_ChemicalName_IUPAC = 'IUPAC (International Union of Pure and Applied Chemistry) refers to standardized nomenclature of organic chemistry. Click the ? for more details.';
top.field_def.STRUCTURE_SMILES = 'SMILES (S implified Molecular Input Line Entry System) molecular text code of displayed STRUCTURE. Click the ? for more details.';
top.field_def.STRUCTURE_Parent_SMILES = 'Same entry as STRUCTURE_SMILES unless STRUCTURE_TestedForm_DefinedOrganic entry is either "salt" or "complex", in which case field entry corresponds to parent structure in desalted or neutralized (protonated) form, without salt counter ions or complexed moieties. Click the ? for more details.';
top.field_def.STRUCTURE_InChI = 'InChI = IUPAC (International Union of Pure and Applied Chemistry) NIST (National Institutes of Standards and Technology) Chemical Identifier, a unique, standardized text-based code or nomenclature for molecular structure. Click the ? for more details.';
top.field_def.StudyType = 'Field entry refers to the main type of toxicity study for which data is represented in the data file. Click the ? for more details.';
top.field_def.Endpoint = 'Field entry refers to the type of toxicity measure represented within the data file. Abbreviations are defined on the main information page for the respective data files and in the corresponding Field Definition File. Click the ? for more details.';
top.field_def.Species = 'Field entry refers to the species of animal(s) used in the toxicity study. Click the ? for more details.';
top.field_def.ActivityOutcome_CPDBAS_Mutagenicity = 'A chemical is classified within the CPDB as mutagenic, i.e. "active", in the Salmonella assay if it was evaluated overall as either "mutagenic" or "weakly mutagenic" by Zeiger [see CPDBAS Ref 4] or as overall "positive" by the EPA Gene-Tox Program [see CPDBAS Ref 5,6]. All other chemicals evaluated for mutagenicity by these two sources are reported as "inactive". Click the ? for more details.';
top.field_def.TD50_Rat_mg = 'TD50 is a standardized quantitative measure of carcinogenic potency (analogous to an LD50) and is computed in the CPDB for each species/sex/tissue/tumor type for each experiment. TD50 is defined as: "that dose-rate in mg/kg body wt/day which, if administered chronically for the standard lifespan of the species, will halve the probability of remaining tumorless throughout that period" [see CPDBAS Ref 4-6]. Click the ? for more details.';
top.field_def.TD50_Rat_mmol = 'TD50_Rat_mmol = TD50_Rat_mg / STRUCTURE_MolecularWeight. See definition for TD50_Rat_mg for details. Click the ? for more details.';
top.field_def.TD50_Rat_Note = 'If a numerical value of the TD50 is listed for a given Species, it may be accompanied by one or more of the Allowable Entries in this field (corresponding to footnote references in the original CPDB Summary Tables). If there were no positive experiments in a species but the chemical was tested in the species, the field entry will be one of the following: " no positive results"; "NTP bioassay inadequate" indicates that the NCI/NTP bioassays were the only available experiments, and results for both sexes in the species were evaluated by the NCI/NTP as inadequate. Click the ? for more details.';
top.field_def.TargetSites_Rat_Male = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TargetSites_Rat_Female = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TargetSites_Rat_BothSexes = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. This field is used for experiments where results in the general literature are reported only for males and females combined, with a positive author\'s opinion for the particular site. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TD50_Mouse_mg = 'TD50 is a standardized quantitative measure of carcinogenic potency (analogous to an LD50) and is computed in the CPDB for each species/sex/tissue/tumor type for each experiment. TD50 is defined as: "that dose-rate in mg/kg body wt/day which, if administered chronically for the standard lifespan of the species, will halve the probability of remaining tumorless throughout that period" [see CPDBAS Ref 4-6]. Click the ? for more details.';
top.field_def.TD50_Mouse_mmol = 'TD50_Mouse_mmol = TD50_Mouse_mg / STRUCTURE_MolecularWeight. See definition for TD50_Rat_mg for details. Click the ? for more details.';
top.field_def.TD50_Mouse_Note = 'If a numerical value of the TD50 is listed for a given Species, it may be accompanied by one or more of the Allowable Entries in this field (corresponding to footnote references in the original CPDB Summary Tables). If there were no positive experiments in a species but the chemical was tested in the species, the field entry will be one of the following: " no positive results"; "NTP bioassay inadequate" indicates that the NCI/NTP bioassays were the only available experiments, and results for both sexes in the species were evaluated by the NCI/NTP as inadequate. Click the ? for more details.';
top.field_def.TargetSites_Mouse_Male = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TargetSites_Mouse_Female = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TargetSites_Mouse_BothSexes = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. This field is used for experiments where results in the general literature are reported only for males and females combined, with a positive author\'s opinion for the particular site. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TD50_Hamster_mg = 'TD50 is a standardized quantitative measure of carcinogenic potency (analogous to an LD50) and is computed in the CPDB for each species/sex/tissue/tumor type for each experiment. TD50 is defined as: "that dose-rate in mg/kg body wt/day which, if administered chronically for the standard lifespan of the species, will halve the probability of remaining tumorless throughout that period" [see CPDBAS Ref 4-6]. Click the ? for more details.';
top.field_def.TD50_Hamster_mmol = 'TD50_Hamster_mmol = TD50_Hamster_mg / STRUCTURE_MolecularWeight. See definition for TD50_Rat_mg for details. Click the ? for more details.';
top.field_def.TD50_Hamster_Note = 'If a numerical value of the TD50 is listed for a given Species, it may be accompanied by one or more of the Allowable Entries in this field (corresponding to footnote references in the original CPDB Summary Tables). If there were no positive experiments in a species but the chemical was tested in the species, the field entry will be " no positive results". Click the ? for more details.';
top.field_def.TargetSites_Hamster_Male = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TargetSites_Hamster_Female = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TargetSites_Hamster_BothSexes = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. This field is used for experiments where results in the general literature are reported only for males and females combined, with a positive author\'s opinion for the particular site. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TD50_Dog_mg = 'TD50 is a standardized quantitative measure of carcinogenic potency (analogous to an LD50) and is computed in the CPDB for each species/sex/tissue/tumor type for each experiment. TD50 is defined as: "that dose-rate in mg/kg body wt/day which, if administered chronically for the standard lifespan of the species, will halve the probability of remaining tumorless throughout that period" [see CPDBAS Ref 4-6]. Click the ? for more details.';
top.field_def.TargetSites_Dog = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TD50_Rhesus_mg = 'TD50 is a standardized quantitative measure of carcinogenic potency (analogous to an LD50) and is computed in the CPDB for each species/sex/tissue/tumor type for each experiment. TD50 is defined as: "that dose-rate in mg/kg body wt/day which, if administered chronically for the standard lifespan of the species, will halve the probability of remaining tumorless throughout that period" [see CPDBAS Ref 4-6]. Click the ? for more details.';
top.field_def.TargetSites_Rhesus = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TD50_Cynomolgus_mg = 'TD50 is a standardized quantitative measure of carcinogenic potency (analogous to an LD50) and is computed in the CPDB for each species/sex/tissue/tumor type for each experiment. TD50 is defined as: "that dose-rate in mg/kg body wt/day which, if administered chronically for the standard lifespan of the species, will halve the probability of remaining tumorless throughout that period" [see CPDBAS Ref 4-6]. Click the ? for more details.';
top.field_def.TargetSites_Cynomolgus = 'Target sites are identified on the basis of a positive opinion by the published author for the particular site, in any experiment in the species-sex or species, using all results from both the general literature and NCI/NTP bioassays. If a chemical has two or more target sites listed, the results may be from different experiments, and a single site may be a target organ from more than one experiment. Click the ? for more details.';
top.field_def.TD50_Dog_Primates_Note = 'If a numerical value of the TD50 is listed for a given Species, it may be accompanied by one or more of the Allowable Entries in this field (corresponding to footnote references in the original CPDB Summary Tables). If there were no positive experiments in a species but the chemical was tested in the species, the field entry will be " no positive results". Click the ? for more details.';
top.field_def.ActivityOutcome_CPDBAS_SingleCellCall = 'Carcinogenic activity based on minimal evidence for or against activity: "active" = one or more TD50 and tumor site listed for one or more carcinogenicity sex/species cell (e.g., Rat Male, Rat Female, etc); "inactive" = no TD50 or tumor site listed AND one or more "no positive results" entry for one or more carcinogenicity sex/species cell (e.g., Rat Male, Rat Female, etc), i.e. one or more experiments are reported in the CPDB, but none are positive; "unspecified" = NCI/NTP bioassays were the only available experiments and both sexes in the species were evaluated by NCI/NTP as inadequate, corresponds to "NTP bioassay inadequate" entry in TargetSites field. Click the ? for more details.';
top.field_def.ActivityOutcome_CPDBAS_MultiCellCall = 'Carcinogenic activity based on multicell evidence for or against activity: "active" = more than one TD50 or tumor site listed for carcinogenicity sex/species cells (e.g., liver, lung, or Rat Male, Rat Female, etc); "inactive" = no TD50 or tumor site listed AND more than one "no positive results" entry for carcinogenicity sex/species cells. Click the ? for more details.';
top.field_def.ActivityOutcome_CPDBAS_MultiCellCall_Details = 'Details pertaining to ActivityOutcome_CPDBAS_MultiCellCall: "active" entry indicates one or more of the following are listed: multisite active; multisex active; multispecies active. "inactive" entry indicates one or more of the following are listed: multisex inactive; multispecies inactive. Click the ? for more details.';
top.field_def.Note_CPDBAS = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.NTP_TechnicalReport = 'National Toxicology Program Technical Report number of study included in this CPDBAS record. Note is also included in this field if NTP study results differ from CPDB summary call to alert users to this discrepancy. Click the ? for more details.';
top.field_def.Website_URL = 'Internet URL website address linking to general Source information page or list. URL was checked at time of DSSTox data file publication. Please send DSSTox Error Report if website URL address no longer works or is changed. Click the ? for more details.';
top.field_def.ChemClass_DBP = 'Chemical classification categories considered in analog searches and in developing structure-activity relationship (SAR) rationales for predicting carcinogenic potential rankings. Click the ? for more details.';
top.field_def.ActivityConcernLevel_Carcinogenicity = 'Concern level predictions are based on expert judgment relative to known carcinogens and using principles of mechanism-based structure-activity analysis. Factors taken into consideration include structural analogy to known carcinogens, toxicokinetic and toxicodynamic factors, potency indicators for a structural analog (such as multispecies, multitarget or multisite carcinogens), short-term test data, and metabolic activation. Click the ? for more details.';
top.field_def.ActivityConcernLevel_Rationale = 'Concise narrative statement summarizing evidence supporting the prediction of carcinogenic potential for the DBP chemical. Rationale is derived from mechanism-based SAR analysis, and is strongly reliant on identification of one or a few close structural analogs with known carcinogenicity and supplemented by extensive literature search for genotoxicity and other data. Click the ? for more details.';
top.field_def.ActivityConcernLevel_RationaleSource = 'Source of rationale narrative, either from DBPCAN Main Citation (Tables 5,6,7, or 9) or from supplemental material provided by author communication. Click the ? for more details.';
top.field_def.Analog_ChemicalName = 'Chemical name of primary structural analog cited in ActivityConcernLevel_Rationale for SAR carcinogenic potential prediction listed in Table 1 of DBPCAN Main Citation. Click the ? for more details.';
top.field_def.Analog_CASRN = 'CASRN of primary structural analog cited in SAR rationale for carcinogenic potential prediction, corresponding to Analog_ChemicalName. Click the ? for more details.';
top.field_def.Analog_SMILES = 'SMILES code of primary structural analog cited in SAR rationale for carcinogenic potential prediction, corresponding to Analog_ChemicalName. Click the ? for more details.';
top.field_def.Note_DBPCAN = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.ChemClass_FHM = 'Standard organic chemical class designations of the sort used in traditional QSAR studies. These class designations are only provided for information purposes in EPAFHM and were not used in the construction of Mode-of-action (MOA) classes or derivation of quantitative structure-activity relationships (QSARs) for this study. Click the ? for more details.';
top.field_def.CLOGP = 'Logarithm of the octano/water partition coefficient (LogP) computed using the semiempirical fragment-based method applied in the CLOGP software [see EPAFHM Ref 2], unless "measured LogP" appears in MLOGP field in which case the measured LogP value is provided in the CLOGP field from the STARLIST database of CLOGP. Click the ? for more details.';
top.field_def.MLOGP = '"measured LogP" indicates CLOGP field value is obtained from the STARLIST database of experimentally measured LogP values provided in the CLOGP application [see EPAFHM Ref 2]; "blank" or null entry indicates the CLOGP field value is computed from the CLOGP semiempirical fragment-based method. Click the ? for more details.';
top.field_def.LC50_mg = '97 hr LC50 (concentration producing lethality in 50% of test animals after 96 hours exposure) in mg/l. Calculated using Spearman-Karber method [see EPAFHM Ref 3]. Geometric mean of LC50s presented if more than one bioassay conducted for the chemical; "blank" or null entry indicates no mortality, or less than 50% mortality observed at 96hr. Click the ? for more details.';
top.field_def.LC50_mmol = 'Conversion of LC50_mg to mmol units: LC50_mmol = LC50_mg / STRUCTURE_MolecularWeight; "blank" or null entry indicates no mortality, or less than 50% mortality observed at 96hr. Click the ? for more details.';
top.field_def.LC50_Ratio = 'Used for dose-response assessments in the estimation of MOA; entry is ratio of 24hr LC50 to 96hr LC50 unless otherwise noted (for ratios of 48hr or 72hrs to 96hrs) in LC50_Note field. "blank" or null entry indicates ratio was not computed with reason provided in LC50_Note field. Click the ? for more details.';
top.field_def.LC50_Note = 'Comments regarding the LC50_mg value and LC50_Ratio determination; pertain to exceptional situations, e.g., where: 50% mortality could not be achieved at saturation concentrations, non-monotonical pattern of death was observed (i.e., more deaths at lower concentrations than at higher concentrations), or exceptions were made in terms of pH or mixtures. Click the ? for more details.';
top.field_def.MOA = 'Mode-of-action (MOA) of chemical assigned by authors of study based on joint toxic action studies, establishment of toxicodynamic profiles, and behavioral and dose-response interpretation of 96 hr LC50 tests. Further description of MOA categories is provided in EPAFHM Main Citation (Russom et al., 1997). Click the ? for more details.';
top.field_def.MOA_Confidence = 'Level of confidence placed in MOA classification based on available evidence: "High" = FishAcuteToxSyndrome, joint toxicity MixtureTest determination and/or chemical-specific literature confirmation; High-Moderate = behavior syndrome, LC50_Ratio, and ExcessToxicityIndex value all consistent with structurally similar chemical with MOA assignment and "High" level confidence; also if LC50 ratio and ExcessToxicityIndex consistent with prototypical compound in MOA group; "Moderate" = less than 3 level "High-Moderate" components, but additional supporting information available (such as concentration/response slope, behavior comments, chemical similarity to prototypical compound); "Low" = no confidence in MOA classification due to insufficient data. Click the ? for more details.';
top.field_def.MOA_MixtureTest = 'If a mixture test was conducted and the chemical was additive with a chemical of known MOA as described by Broderius et al. [see EPAFHM Ref 4], an MOA was assigned (see field definition); "blank" or null entry indicates no mixture test was performed. Click the ? for more details.';
top.field_def.ExcessToxicityIndex = 'Ratio of the predicted toxicity of the compound using Baseline narcosis (Narcosis I) QSAR equation of Veith et al. [see EPAFHM Ref 5]: Log molar LC50 = -0.94 logP + log(0.000068*P +1) - 1.25 (P=octanol/water partition coeff), divided by the actual LC50, used as a measure of excess toxicity. Click the ? for more details.';
top.field_def.FishAcuteToxSyndrome = 'If a fish acute toxicity syndrome (FATS) test was conducted using rainbow trout as described by McKim et al. [see EPAFHM Ref 6,7], the MOA that was determined from that test is listed. FATS MOA assignments consistent with MOA assignment of chemical from other indicators for fathead minnow provide the highest level of confidence (A) to the chemical MOA assignment (see MOA field definitions); "blank" or null entry indicates no FATS test was performed. Click the ? for more details.';
top.field_def.FishBehaviorTest = 'Behavior signs of stress were identified for fathead minnows exposed to toxicants and were used to classify chemicals into three behavioral syndromes as described by Drummond and Russom [see EPAFHM Ref 8]. These were used to determine level of confidence of MOA assignment. Click the ? for more details.';
top.field_def.Note_EPAFHM = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.ChemClass_ERB = 'Six main estrogenic receptor binding (ERB) structural classes with subclass designations utilized in the NCTRER Main Citation (Fang et al., 2001). "Misc" (Miscellaneous) category contains structurally diverse compounds that do not fit into one of the six main structural classes. Main structural class (e.g., Phytoestrogens) is listed before subclass, as in, e.g., Phytoestrogens Flavones or Biphenyls PCBs. Click the ? for more details.';
top.field_def.ER_RBA = 'Estrogen receptor relative binding affinity determined using a competitive receptor binding assay in which a chemical competes with radiolabeled estradiol (E2) for binding to the ER in rat uterine cytosol and the IC50 is measured. ER_RBA is calculated by dividing the IC50 of E2 (9X10-10M) by the IC50 of the competitor and multiplying by 100 (E2 RBA = 100). Click the ? for more details.';
top.field_def.LOG_ER_RBA = 'Logarithm (base 10) of ER_RBA is the measure of activity provided by the NCTR Source and used by NCTRER Main Citation (Fang et al., 2001) and others for QSAR modeling study. For slight binders, ER_RBA=0 and LOG_ER_RBA is assigned the numeric value of -5,000. For inactives, ER_RBA=0 and LOG_ER_RBA is assigned the numeric value of -10,000. Click the ? for more details.';
top.field_def.ActivityCategory_ER_RBA = 'For purposes of SAR analysis, NCTRER Main Citation (Fang et al., 2001) divided the NCTRER data set into five main activity categories: active strong (ER_RBA > 1); active medium (1> ER_RBA > 0.01); active weak (0.01 > ER_RBA > 1E-5); slight binder (max< 50% inhibition or ER_RBA< 1E-5); inactive (no activity, equates with NA designation) Click the ? for more details.';
top.field_def.Mean_ER_RBA_ChemClass = 'Values are computed within each of the six main structural classes as the geometric mean of ER_RBA activities, based only on the active chemicals within each class; "blank" or null entry indicates calculation not applicable to chemicals in the "Misc" class. Click the ? for more details.';
top.field_def.ActivityCategory_Rationale_ChemClass_ERB = 'Qualitative structure-activity rationale relating what is known or inferred concerning the structural basis for estrogenic activity within each of the 20 structural subclasses (ChemClass_ERB). Brief narrative statement intended to summarize the lengthier discussion in the NCTRER Main Citation (Fang et al., 2001). Click the ? for more details.';
top.field_def.F1_Ring = 'First decision point in Flowchart (see NCTRER_FieldDefFile), and in Fig. 14 of NCTRER Main Citation (Fang et al., 2001). Value indicates the presence or absence of a ring in the chemical structure, either aromatic or not: 1 = yes; 0 = no. If a chemical contains no ring structure (F1=0), it is unlikely to be an ER ligand. Click the ? for more details.';
top.field_def.F2_AromaticRing = 'Second decision point in Flowchart (see NCTRER_FieldDefFile), and in Fig. 14 of NCTRER Main Citation (Fang et al., 2001). Value indicates the presence or absence of an aromatic ring in the chemical structure: 1 = yes (only if F1=1); 0 = no. Click the ? for more details.';
top.field_def.F3_PhenolicRing = 'Third decision point in Flowchart (see NCTRER_FieldDefFile), and in Fig. 14 of NCTRER Main Citation (Fang et al., 2001). Value indicates the presence or absence of a phenolic ring in the chemical structure: 1 = yes (only if F1=F2=1); 0 = no. Click the ? for more details.';
top.field_def.F4_Heteroatom = 'Fourth decision point in Flowchart (see NCTRER_FieldDefFile), and in Fig. 14 of NCTRER Main Citation (Fang et al., 2001), only reached if F1=1 and F2=0. Value indicates the presence or absence of a H-bond capable heteroatom (O,S,N) attached to a non-aromatic ring structure: 1 = yes (only if F1=1, F2=0); 0 = no. Click the ? for more details.';
top.field_def.F5_Phenol3nPhenyl = 'Fifth decision point in Flowchart (see NCTRER_FieldDefFile), and in Fig. 14 of NCTRER Main Citation (Fang et al., 2001), only reached if F1=F2=F3=1. Value indicates the presence or absence of a phenolic ring linked by 1-3 bridging atoms (C or O) to another aromatic ring system: 1 = yes; 0 = no. If F5=1, compound is likely an ER ligand. Click the ? for more details.';
top.field_def.F6_OtherKeyFeatures = 'Indicator value of sixth decision point in Flowchart (see NCTRER_FieldDefFile), and in Fig. 14 of NCTRER Main Citation (Fang et al., 2001), indicating the presence or absence of a key structural feature conferring activity: 1 = yes; 0 = no. Decision point reached if F1=1 and F4=1, F3=0, or F5=0. Definitive rules for determining presence of key structural features are not provided here but usually are implied by ERB activity. Click the ? for more details.';
top.field_def.LOGP = 'Logarithm of the octanol/water partition coefficient computed by the fragment method of Meylan and Howard [see NCTRER Ref 1]. Physicochemical property provides an approximate measure of hydrophobicity; values too high or too low can be associated with poor transport characteristics. Click the ? for more details.';
top.field_def.Note_NCTRER = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.ChemicalReplicateCount = 'Counter field specifying instances of replicates or related forms in the data file (i.e. structurally related chemicals assigned the same activity, or replicate sets of substances within a file). Entry is "1" in first case of unique substance, parent structure, or 2D structure. If replicates or related forms exist, entry is a counter number (1,2,3, etc) followed by "of" and the total number of replicates or related forms for that case., e.g.: 1 of 3, 2 of 3, 3 of 3, are 3 record entries in a case of 3 replicates. Click the ? for more details.';
top.field_def.ChemClass_MRDD_grouping = 'Non-blank entry only when closely related chemical derivatives are a member of a group assigned the same MRDD activity, Dose_MRDD_mg, within the data file. All members of the group are assigned a common ChemClass_MRDD_grouping name and ChemicalReplicateCount values ranging from "1 of n" to "n of n", where n is the number of derivatives included in the ChemClass_MRDD_grouping. Click the ? for more details.';
top.field_def.TherapeuticCategory = 'Therapeutic categories for use of drug as listed in Merck Index, 12th Ed. Click the ? for more details.';
top.field_def.Dose_MRDD_mg = 'Maximum recommended daily dose (or maximum recommended therapeutic dose) values were determined from pharmaceutical clinical trials that employed an oral route of exposure and daily treatments, usually for 3-12 months. Drugs were given as single or divided dose treatment regimens to achieve desired pharmacological effects. The mg/day unit was converted to mg/kg-body weight (bw)/day based upon an average adult weighing 60 kg. Click the ? for more details.';
top.field_def.Dose_MRDD_mmol = 'Maximum recommended daily dose measure, Dose_MRDD_mg, converted to millimoles: Dose_MRDD_mmol = Dose_MRDD_mg / STRUCTURE_MolecularWeight. Note that this mg to mmol conversion in FDAMDD assumes that the compound dose in mg corresponds to the dose of the active ingredient in a formulation. Click the ? for more details.';
top.field_def.LOGINV_MRDD_mmol = 'LOGINV_MRDD_mmol = Log10(1/Activity) = Log(1/Dose_MRDD_mmol) [base 10] Click the ? for more details.';
top.field_def.ActivityScore_FDAMDD = 'Mapping of LOGINV_MRDD_mmol spanning activity range [MIN, MAX] onto Integer 1-100 Activity range, where 100 is highest potency and 1 is lowest potency: ActivityScore = 100 * INTEGER[(LOGINV_MRDD_mmol - MIN)/(MAX - MIN)]. Click the ? for more details.';
top.field_def.ActivityCategory_MRDD_mmol = 'Based on ActivityScore_FDAMDD 100 scale, provides qualitative estimate of activity or potency of chemical within data file; ActivityScore_FDAMDD range listed along with Dose_MRDD_mmol range for each activity category: High (100-50) = (1.3E-8 to 3.6E-4 mmol); High-Moderate (49-45) = (3.7E-4 to 1.0E-3 mmol); Moderate (44-30) = (1.1E-3 to 2.2E-2 mmol); Low-Moderate (29-25) = (2.3E-2 to 6.3E-2 mmol); Low (24-0) = (6.4E-2 to 1.1E+1 mmol). Click the ? for more details.';
top.field_def.ActivityCategory_MCASE_mg = 'The FDAMDD Main Citation (Matthews et al, 2004) reported two different sets of activity classification cutoffs used for separate MCASE analyses of "Inactives" and "Actives". These cutoffs correspond reasonably closely between High and Marginal categories, and almost exactly between Marginal and Low categories in that study. Click the ? for more details.';
top.field_def.Note_FDAMDD = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.NTP_StudyArea_ImmunoTox = 'One of the 4 Study Areas (Immunologic Toxicity) for which bioassay data may be available, indexed by chemical substance, in the NTP Bioassay On-Line Database of the NIEHS National Toxicology Program. Indicator values indicate the presence or absence of study data in this Study Area: 1 = study data available; 0 = no study data available. Click the ? for more details.';
top.field_def.NTP_StudyArea_GeneTox = 'One of the 4 Study Areas (Genetic Toxicity) for which bioassay data may be available, indexed by chemical substance, in the NTP Bioassay On-Line Database of the NIEHS National Toxicology Program. Indicator values indicate the presence or absence of study data in this Study Area: 1 = study data available; 0 = no study data available. Click the ? for more details.';
top.field_def.NTP_StudyArea_CancerChronicTox = 'One of the 4 Study Areas (Cancer/Chronic Toxicity) for which bioassay data may be available, indexed by chemical substance, in the NTP Bioassay On-Line Database of the NIEHS National Toxicology Program. Indicator values indicate the presence or absence of study data in this Study Area: 1 = study data available; 0 = no study data available. Click the ? for more details.';
top.field_def.NTP_StudyArea_DevelopTox = 'One of the 4 Study Areas (Developmental Toxicity) for which bioassay data may be available, indexed by chemical substance, in the NTP Bioassay On-Line Database of the NIEHS National Toxicology Program. Indicator values indicate the presence or absence of study data in this Study Area: 1 = study data available; 0 = no study data available. Click the ? for more details.';
top.field_def.Note_NTPBSI = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.Oral_RfD_Assessed = 'Value indicates whether oral exposure Reference Dose (RfD) was assessed (1) or not (0) for this substance. See Oral_RfD_mg_per_kg_day for definition of oral reference dose. Click the ? for more details.';
top.field_def.Oral_RfD_CriticalEffects = 'Critical Effects are defined as the first adverse effect, or its known precursor, that occurs to the most sensitive species as the dose rate of an agent increases. Listed here are critical effects pertaining to oral exposures that are used to compute oral reference doses (RfD) for the substance. Click the ? for more details.';
top.field_def.Oral_RfD_mg_per_kg_day = 'Oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is based on oral exposure and expressed in units of mg/kg-day. It is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily oral exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Click the ? for more details.';
top.field_def.Oral_RfD_mmol_per_kg_day = 'Oral_RfD_mg_per_kg_day value converted to molar units in cases where test substance is not a mixture of different molecular weight substances, based on formula: Oral_RfD_mg_per_kg_day/STRUCTURE_MolecularWeight. Click the ? for more details.';
top.field_def.Oral_RfD_Notes = 'Point of Departure is the dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD - Benchmark dose), or a NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) for an observed incidence, or change in level of response. Click the ? for more details.';
top.field_def.Oral_RfD_Confidence = 'Confidence in Oral RfD is based on several factors, including availability of epidemiology and other supporting data, quality of studies, magnitude of effect, etc. Click the ? for more details.';
top.field_def.Inhalation_RfC_Assessed = 'Value indicates whether inhalation exposure Reference Dose was assessed (1) or not (0) for this substance. See Inhalation_RfC_mg_per_m3 for definition of inhalation reference dose. Click the ? for more details.';
top.field_def.Inhalation_RfC_CriticalEffects = 'Critical Effects are defined as the first adverse effect, or its known precursor, that occurs to the most sensitive species as the dose rate of an agent increases. Listed here are critical effects pertaining to oral exposures that are used to compute oral reference doses (RfD) for the substance. Click the ? for more details.';
top.field_def.Inhalation_RfC_mg_per_m3 = 'Inhalation Reference Concentration (RfC) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is based on inhalation exposure and expressed in units of mg/m3 air volume. It is an estimate (with uncertainty spanning perhaps an order of magnitude) of a continuous inhalation exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Click the ? for more details.';
top.field_def.Inhalation_RfC_mmol_per_m3 = 'Inhalation_RfC_mg_per_m3 value converted to molar units in cases where test substance is not a mixture of different molecular weight substances, based on formula: Inhalation_RfC_mg_per_m3/STRUCTURE_MolecularWeight. Click the ? for more details.';
top.field_def.Inhalation_RfC_Notes = 'Point of Departure is the dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD - Benchmark dose), or a NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) for an observed incidence, or change in level of response. Click the ? for more details.';
top.field_def.Inhalation_RfC_Confidence = 'Confidence in Inhalation RfC is based on several factors, including availability of epidemiology and other supporting data, quality of studies, magnitude of effect, etc. Click the ? for more details.';
top.field_def.WtOfEvidence_Cancer_Assessed = 'Value indicates whether Weight of Evidence for Carcinogenicity was assessed (1) or not (0) for this substance. See WtOfEvidence_Cancer_Narrative for description of approach. Click the ? for more details.';
top.field_def.WtOfEvidence_Cancer_Concern = 'Weight-of-Evidence (WOE) for carcinogenicity Concern Level is assigned based on the type and sufficiency of evidence available for human risk and takes one of the following values: High, Medium-High, Medium, Low-Medium, Low, Inadequate evidence. Click the ? for more details.';
top.field_def.WtOfEvidence_1986GuidelineCategories = 'Based on the EPA\'s 1986 Cancer Risk Assessment Guidelines, the Weight of Evidence determination assigns the substance to one of 6 categories. The majority of IRIS Cancer Risk assessments are based on the 1986 guidelines. However, updates to these guidelines were published in 1996, 1999 and 2005, and superseded the earlier 1986 guidelines. Click the ? for more details.';
top.field_def.WtOfEvidence_Cancer_Narrative = 'Weight-of-Evidence (WOE) for Carcinogenicity is a system used by the U.S. EPA for characterizing the extent to which the available data support the hypothesis that an agent causes cancer in humans. Revised guidelines published in 1996, 1999, and 2005 have modified these cancer risk characterizations. The approach outlined in EPA\'s guidelines for carcinogen risk assessment (2005) considers all scientific information in determining whether and under what conditions an agent may cause cancer in humans, and provides a narrative approach to characterize carcinogenicity rather than categories. Click the ? for more details.';
top.field_def.DrinkingWater_OralSlope_Assessed = 'Value indicates whether drinking water oral exposure Slope Factor was assessed (1) or not (0) for this substance. See DrinkingWater_OralSlopeFactor_mg_per_kg_day for definition of drinking water Oral Slope Factor. Click the ? for more details.';
top.field_def.DrinkingWater_PrecursorEffect_TumorType = 'Listing of the pre-carcinogenic cellular abnormality and/or tumor type that factor into the determination of the Oral Slope Factor and Unit Risk. Click the ? for more details.';
top.field_def.DrinkingWater_OralSlopeFactor_mg_per_kg_day = 'Slope Factor refers to an upper bound, approximating a 95% confidence limit, on the increased cancer risk from a lifetime exposure to an agent. Values reported here are computed from oral drinking water exposure data and expressed in units of mg/kg-(body weight) per day. Click the ? for more details.';
top.field_def.DrinkingWater_OralSlopeFactor_mmol_per_kg_day = 'DrinkingWater_OralSlopeFactor_mg_per_kg_day value converted to molar units in cases where test substance is not a mixture of different molecular weight substances, based on formula: DrinkingWater_OralSlopeFactor_mg_per_kg_day/STRUCTURE_MolecularWeight. Click the ? for more details.';
top.field_def.DrinkingWater_ExtrapolationMethod_Notes = 'Lists extrapolation method used to compute Oral Slope Factor and additional details of this calculation. May also list any additional Oral Slope Factors and Unit Risks for this substance, indication of extra risk, and units. Click the ? for more details.';
top.field_def.DrinkingWater_UnitRisk_microg_per_L = 'Unit Risk is defined as the upper-bound excess lifetime cancer risk estimated to result from continuous exposure to an agent at a concentration of 1 microg/L in water, or 1 microg/m3 in air, e.g., if unit risk = 2 x 10-6 per microg/L, 2 excess cancer cases (upper bound estimate) are expected to develop per 1,000,000 people if exposed daily for a lifetime to 1 microg of the chemical in 1 liter of drinking water. Units are microgram/L. Click the ? for more details.';
top.field_def.DrinkingWater_UnitRisk_micromol_per_L = 'DrinkingWater_UnitRisk_microg_per_L value converted to molar units in cases where test substance is not a mixture of different molecular weight substances, based on formula: DrinkingWater_UnitRisk_microg_per_L/STRUCTURE_MolecularWeight. Click the ? for more details.';
top.field_def.DrinkingWater_StudyRoute = 'Route of administration of study used to estimate Drinking Water exposure route Oral Slope Factor and Unit Risk. Possibilities include: diet, drinking water, gavage, inhalation, occupational exposure, oral. Click the ? for more details.';
top.field_def.Inhalation_UnitRisk_Assessed = 'Value indicates whether inhalation exposure Unit Risk was assessed (1) or not (0) for this substance. See Inhalation_UnitRisk_microg_per_m3 for description of inhalation exposure Unit Risk values. Click the ? for more details.';
top.field_def.Inhalation_PrecursorEffect_TumorType = 'Listing of the pre-carcinogenic cellular abnormality and/or tumor type that factor into the determination of the Air Unit Risk. Precursor effects in specified organ/tissues include, e.g., adenomas, neoplastic nodules, carcinomas, astrocytomas, papillomas. Tumors are indicated by listing of organ or tissue without additional qualifiers, e.g., bladder, liver, kidney, etc. Click the ? for more details.';
top.field_def.Inhalation_UnitRisk_microg_per_m3 = 'Unit Risk is defined as the upper-bound excess lifetime cancer risk estimated to result from continuous exposure to an agent at a concentration of 1 microg/L in water, or 1 microg/m3 in air, e.g., if unit risk = 2 x 10-6 per microg/L, 2 excess cancer cases (upper bound estimate) are expected to develop per 1,000,000 people if exposed daily for a lifetime to 1 microg of the chemical in 1 liter of drinking water. Units are microgram/cubicmeter volume of air. Click the ? for more details.';
top.field_def.Inhalation_UnitRisk_micromol_per_m3 = 'Inhalation_UnitRisk_microg_per_m3 value converted to molar units in cases where test substance is not a mixture of different molecular weight substances, based on formula: Inhalation _UnitRisk_microg_per_m3 / STRUCTURE_MolecularWeight. Click the ? for more details.';
top.field_def.Inhalation_StudyRoute = 'Route of administration of study used to estimate Inhalation exposure route Oral Slope Factor and Unit Risk. Possibilities include: diet, drinking water, gavage, inhalation, occupational exposure, oral. Click the ? for more details.';
top.field_def.Inhalation_ExtrapolationMethod_Notes = 'Lists extrapolation method used to compute Air (Inhalation) Unit Risk and additional details of this calculation. May also list any additional Unit Risks for a substance, indication of extra risk, and units. Extrapolation methods include, e.g., linearized multi-stage procedure, one-hit with time factor, multistage model with Benchmark Dose modeling, etc. Click the ? for more details.';
top.field_def.TotalAssessments = 'Sum of indicator values (0,1) for assessments in 5 toxicity review areas, with total ranging from 0-5 providing a rough indication the amount of study data available for a given substance. Click the ? for more details.';
top.field_def.Note_IRISTR = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.Note_NTPHTS = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.PubChem_CID = 'PubChem Chemical ID (CID) used as identifier of unique structure assigned to chemical substance record after deposition in PubChem. Click the ? for more details.';
top.field_def.Pubchem_SID = 'PubChem Substance ID (SID) used as identifier of unique Source-specific substance record upon deposition in PubChem. Click the ? for more details.';
top.field_def.HPV_Indicator = 'Entry signifies whether the chemical falls within or outside the scope of the HPV Challenge Program. Click the ? for more details.';
top.field_def.HPV_Chemical_Sponsorship_Status = 'Entry signifies whether or not a chemical has been sponsored in the HPV Challenge Program, whether it is listed in the proposed "Testing of Certain High Production Volume Chemicals; Data Collection and Development on High Production Volume (HPV) Chemicals" rule (65 FR 81658), or whether it is listed in the Voluntary Children\'s Chemical Evaluation Program notice (64 FR 81699). Click the ? for more details.';
top.field_def.HPV_TestPlan_Chemical = 'Test plan for chemical is available (Yes), will not be available (No), or status is indeterminant (blank or null entry). Click the ? for more details.';
top.field_def.HPV_TestPlan_ChemicalCategory = 'A chemical category, for the purposes of the Challenge Program, is a group of chemicals whose physicochemical and toxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity. Click the ? for more details.';
top.field_def.HPVProgram_ChemicalList_URL = 'URL links to the EPA webpage providing description of the 3 main lists from which the current HPVCSI file was compiled: http://www.epa.gov/chemrtk/pubs/update/hpv_1990.htm; http://www.epa.gov/chemrtk/pubs/update/hpv_1994.htm; http://www.epa.gov/chemrtk/pubs/update/hpvadds.htm Click the ? for more details.';
top.field_def.WtOfEvidence_UpdatedGuidelinesUsed = 'Field entry indicates when updated (newer than 1986) EPA Guidelines were used in the Weight of Evidence determination for cancer. Entry makes reference to 1996, 1999, or 2005 updated EPA Guidelines, with additional details provided in the WtOfEvidence_Cancer_Narrative field. Click the ? for more details.';
top.field_def.NTP_CAS_Code = 'Code used by the NTP to index all test chemical substances contained in the on-line NTP database, consists either of the CAS registry number, if available, that is used by the NTP or a character name abbreviation in cases of mixtures, non-chemical stressors, or other cases where CAS registry numbers are unavailable (e.g., GLYCINEBENZA or EMTDP-91). Click the ? for more details.';
top.field_def.EPA_PC_Code = 'Pesticide Chemical Code (PC Code) is a 6 digit number assigned by the US EPA Office of Pesticide Programs (OPP) for internal tracking purposes and in published documents; it most often refers to pesticidal active ingredients, but tracks other substances as well. Click the ? for more details.';
top.field_def.ToxCast_TestingStatus = 'Status of the chemical substance in the EPA ToxCast Phase I reseach program: "pending" - substance is included as initial candidate for high-throughput screening in ToxCast assays; "in progress" - substance is included in test set submitted for high-throughput screening in ToxCast assays; "discontinued" - substance not moved from "pending" to "in progress" status due to unavailability, insolubility or other problems making it unsuitable for high-throughput screening; "complete" - substance has completed all hight-throughput screening in ToxCast assays. Click the ? for more details.';
top.field_def.Note_TOXCST = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields, with text entries to allow a user to easily locate added or modified records in version updates (see, e.g., CPDBAS) Click the ? for more details.';
top.field_def.ChemicalPage_URL = 'Internet URL website address for chemical-specific data or content. URL was checked at time of DSSTox data file publication. Please send DSSTox Error Report if website URL address no longer works or is changed. Click the ? for more details.';
top.field_def.Note_HPVCSI = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields, with text entries to allow a user to easily locate added or modified records in version updates (see, e.g., CPDBAS) Click the ? for more details.';
top.field_def.STRUCTURE_InChIKey = '"InChIKey" is a fixed-length (25-character) condensed digital representation of the InChI Identifier that can be used to facilitate structure look-up; the full InChI is required for structure-regeneration. InChIKeys included in DSSTox files were generated using the standard InChI options. For more information, see STRUCTURE_InChI and More on InChI. Click the ? for more details.';
top.field_def.ActivityScore_CPDBAS_Rat = 'For ActivityOutcome_CPDBAS_Rat = active, ActivityScore is mapping of LOG10 (1/TD50_Rat_mmol) values spanning range [MIN, MAX] onto Integer 1-100 Activity range, where 100 is highest potency and 1 is lowest: ActivityScore = 100 * INTEGER[(log10(1/Activity) - MIN)/(MAX - MIN)]. If activity is reported but no TD50_Rat_mmol value is computed, such as for a mixture, ActivityScore = 50. If ActivityOutcome is either "inactive" or "unspecified", ActivityScore = 0. Click the ? for more details.';
top.field_def.ActivityOutcome_CPDBAS_Rat = 'Carcinogenic activity based on minimal evidence for or against activity: "active" = one or more TD50 and tumor site listed for one or more Rat carcinogenicity cell (Rat Male, Rat Female, Rat Both); "inactive" = no TD50 or tumor site listed AND one or more "no positive results" entry for one or more Rat carcinogenicity cell; "unspecified" = NCI/NTP bioassays were the only available experiments and both sexes in the species were evaluated by NCI/NTP as inadequate. Click the ? for more details.';
top.field_def.ActivityScore_CPDBAS_Mouse = 'For ActivityOutcome_CPDBAS_Mouse = active, ActivityScore is mapping of LOG10 (1/TD50_Mouse_mmol) values spanning range [MIN, MAX] onto Integer 1-100 Activity range, where 100 is highest potency and 1 is lowest: ActivityScore = 100 * INTEGER[(log10(1/Activity) - MIN)/(MAX - MIN)]. If activity is reported but no TD50_Rat_mmol value is computed, such as for a mixture, ActivityScore = 50. If ActivityOutcome is either "inactive" or "unspecified", ActivityScore = 0. For ActivityOutcome "blank" or null, no ActivityScore is reported. Click the ? for more details.';
top.field_def.ActivityOutcome_CPDBAS_Mouse = 'Carcinogenic activity based on minimal evidence for or against activity: "active" = one or more TD50 and tumor site listed for one or more Mouse carcinogenicity cell (Mouse Male, Mouse Female, Mouse Both); "inactive" = no TD50 or tumor site listed AND one or more "no positive results" entry for one or more Mouse carcinogenicity cell; "unspecified" = NCI/NTP bioassays were the only available experiments and both sexes in the species were evaluated by NCI/NTP as inadequate. Click the ? for more details.';
top.field_def.ActivityScore_CPDBAS_Hamster = 'For ActivityOutcome_CPDBAS_Hamster = active, ActivityScore is mapping of LOG10 (1/TD50_Hamster_mmol) values spanning range [MIN, MAX] onto Integer 1-100 Activity range, where 100 is highest potency and 1 is lowest: ActivityScore = 100 * INTEGER[(log10(1/Activity) - MIN)/(MAX - MIN)]. If activity is reported but no TD50_Rat_mmol value is computed, such as for a mixture, ActivityScore = 50. If ActivityOutcome is either "inactive" or "unspecified", ActivityScore = 0. Click the ? for more details.';
top.field_def.ActivityOutcome_CPDBAS_Hamster = 'Carcinogenic activity based on minimal evidence for or against activity: "active" = one or more TD50 and tumor site listed for one or more Hamster carcinogenicity cell (Hamster Male, Hamster Female, Hamster Both); "inactive" = no TD50 or tumor site listed AND one or more "no positive results" entry for one or more Hamster carcinogenicity cell. Click the ? for more details.';
top.field_def.ActivityOutcome_CPDBAS_Dog_Primates = 'Carcinogenic activity based on minimal evidence for or against activity: "active" = one or more TD50 and tumor site listed for one or more Dog/Primate carcinogenicity cell (Dog, Rhesus, Cynomulgus, Tree Shrew, Bush Baby); "inactive" = no TD50 or tumor site listed AND one or more "no positive results" entry for one or more Dog/Primate carcinogenicity experiment cell. Click the ? for more details.';
top.field_def.ActivityOutcome_DBPCAN = 'Activity Outcome maps ActivityConcernLevel_Carcinogenicity as follows: "active" = High, High-Moderate, Moderate, or Low-Moderate; "inconclusive" = Marginal; "inactive" = Low. Click the ? for more details.';
top.field_def.ActivityScore_DBPCAN = 'Activity Score is assigned based on ActivityConcernLevel _Carcinogenicity as follows (using highest route of exposure estimate): High=90; High-Moderate=70; Moderate=50; Low-Moderate=30; Marginal=10; Low=0. Click the ? for more details.';
top.field_def.ActivityOutcome_EPAFHM = 'Categorical activity measure based on reported LC50_mg: "active" if an LC50_mg is reported; "inconclusive" if only partial mortality was reached at the highest tested dose; and "inactive" if no mortality at the highest tested dose. Click the ? for more details.';
top.field_def.ActivityScore_EPAFHM = 'Mapping of LOG10 (1/LC50_mmol) activity values spanning activity range [MIN, MAX] onto Integer 1-100 Activity range, where 100 is highest potency and 1 is lowest. If ActivityOutcome_EPAFHM is "active: ActivityScore = 100 * INTEGER[(log10(1/ LC50_mmol) - MIN)/(MAX - MIN)]. If ActivityOutcome_EPAFHM is "inactive" or "inconclusive": ActivityScore = 0. Click the ? for more details.';
top.field_def.ActivityOutcome_NCTRER = 'Categorical activity measure based on reported LOG_ER_RBA and ActivityCategory_ER_RBA: "active" = active strong, active medium, or active weak (ER_RBA >1E-5); "inconclusive" = slight binder (max< 50% inhibition or ER_RBA< 1E-5); "inactive" = inactive (no activity). Click the ? for more details.';
top.field_def.ActivityScore_NCTRER = 'Mapping of LOG_ER_RBA values >1E-5, spanning activity range [MIN, MAX] onto Integer 20-100 Activity range, where 100 is highest potency and 20 is lowest active potency. If ActivityOutcome_NCTRER is "active: ActivityScore = 80 * INTEGER[(LOG_ER_RBA - MIN)/(MAX - MIN)]. If ActivityOutcome_NCTRER is "inconclusive" (i.e., slight binder): ActivityScore = 5. If ActivityOutcome_NCTRER is "inactive" (i.e., no activity): ActivityScore = 0.0 Click the ? for more details.';
top.field_def.Note_HPVISD = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.Substance_modify_yyyymmdd = 'Sortable numeric date assigned to every unique substance in the DSSTox inventory (i.e., every unique DSSTox_Generic_SID) indicating the most recent date of modification of the structure or Standard Chemical Fields. (Note the date does not apply to changes in the Source-specific toxicity data fields.) yyyymmdd = year, month, day (e.g., 20081021 = 21 October 2008) Click the ? for more details.';
top.field_def.Chemical_StudyType = 'A DSSTox designation assigned to the role of the chemical substance associated with a gene expression experiment. Treatment = a chemical exposure-related experiment in which obtaining gene expression results of chemical treatment is the main focus of the experiment;Reference= the chemical is used as a reference;Combination_Treatment= the study involves more than a single chemical exposure in which gene expression results from multiple chemical treatments are the main focus of the experiment. Combination_TreatmentANDTreatment (or Reference)= the study involves both conditions stated above. Click the ? for more details.';
top.field_def.Experiment_Accession = 'Experiment Accession numbers are used to index experiments within the two largest public gene expression databases, ArrayExpress (ARYEXP) and GEO (GEOGSE). These are also associated with a corresponding Experiment_URL, which links to the URL website associated with the particular ArrayExpress or GEO experiment for the same chemical record. Click the ? for more details.';
top.field_def.Experiment_URL = 'Internet URL website address(s) for chemical-associated experiment data page(s) within the Source website, used for the public gene expression data resources, ArrayExpress (ARYEXP) and GEO (GEOGSE). URLs in this case correspond to the list of Experiment_Accession numbers provided in the same chemical record. Click the ? for more details.';
top.field_def.Note_ARYEXP = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.Note_GEOGSE = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.Source_ChemicalName = 'Common or trade name of chemical listed in original Source data file, which may or may not agree precisely with the generic DSSTox entry provided in TestSubstance_ChemicalName. Field is provided to offer direct correspondence from DSSTox file to Source documentation, in either on-line or journal publication. Click the ? for more details.';
top.field_def.Relationship_CID = 'Field entries document important relationships between records within the same file or across related study files (indicated by NAMEID of file preceeding CID specification). Relationship maps DSSTox_CID, particularly indicating parent0-metabolite pairs, replicate sets, close structural analogs, salt or complex forms, and stereochemistry relationships. Click the ? for more details.';
top.field_def.IC50_microM = 'The concentration of a test chemical that inhibits the maximal specific binding of 0.33 nM radiolabeled (3H) 17-beta-estradiol (E2) to rat uterine cytosolic (RUC) estrogen receptor (ER) by 50%. IC50 is determined from analysis of the competitive binding curves (for more information see BindingCurve_Group and BindingCurve_Details). Click the ? for more details.';
top.field_def.Ki_microM_mean = 'Ki is the inhibition constant for the test chemical, i.e., the concentration of the test chemical that will bind to half the binding sites at equilibrium (displacing half of the probe-bound receptors), in the absence of radioligand or other competitors. Ki reported as Mean +/- Standard Error from n=2 experiments, see StandardError_Ki_n2. Ki determined from LIneweaver-Burk plots over the tested dose range (TestedRange_microM). For more information see BindingCurve_Group and BindingCurve_Details. Click the ? for more details.';
top.field_def.ActivityOutcome_KIERBL = 'Categorical activity based on Ki_microM_mean: "active" = value reported and true competitive binding and inhibition was confirmed by secondary Ki experiments; "inactive" = no binding observed when tested to concentration limit of 100uM, or some binding observed in initial screening but secondary analysis confirmed non-binder status; "inconclusive" = some binding observed, but Ki could not be determined due to solubility limitations that prevented secondary Ki experiment. Click the ? for more details.';
top.field_def.ActivityScore_KIERBL = 'Mapping of LOG10 (Ki_microM_mean) activity values spanning activity range [MAX, MIN] onto Integer 10-100 Activity range. ActivityScore 100 corresponds to natural ligand for ER (17-beta-estradiol), which has lowest Ki value indicative of strongest binder. ActivityScore 10 corresponds to largest Ki value indicative of the weakest binder. If ActivityOutcome_KIERBL is "active: ActivityScore = INTEGER(100*((-LOG10(Ki) + MAX)/ (MAX - MIN))*(0.9) +10). If ActivityOutcome_KIERBL is "inconclusive": ActivityScore = 5. If ActivityOutcome_KIERBL is "inactive": ActivityScore = 0. Click the ? for more details.';
top.field_def.StandardError_Ki_n2 = 'Ki reported as Mean +/- Standard Error from n=2 experiments (see Ki_microM_mean) Click the ? for more details.';
top.field_def.TestedRange_microM = 'Tested dose range for determination of IC50_microM and Ki_microM_mean values. Click the ? for more details.';
top.field_def.BindingCurve_Group = 'General classification of competitive binding curves based on secondary Ki analysis (see Ki_microM_mean). See BindingCurve_Details for further details pertaining to this classification. Click the ? for more details.';
top.field_def.BindingCurve_Details = 'Additional details pertaining to BindingCurve_Group classification of competitive binding curves based on secondary Ki analysis. Click the ? for more details.';
top.field_def.Note_KIERBL = 'Field used to provide supplementary Source-specific information pertaining to the chemical and toxicity fields. Click the ? for more details.';
top.field_def.Assay_Target = 'Field entry refers to the assay target (tissue and receptor) in the case of receptor-based assays and is intended provide assay-specific annotation for resources such as EPA ACToR and PubChem. Click the ? for more details.';