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Endocrine Disruptor Methods Validation Subcommittee (EDMVS)

Seventh Plenary Meeting - June 5-6, 2003

Agenda

PDF File [2pp., 125KB, About PDF] HTML File [16KB]

Federal Register Notices Announcing Meeting | Copy for Public Comment

Endocrine Disruptor Methods Validation Subcommittee under the National Advisory Council for Environmental Policy and Technology; Notice of Public Meeting [PDF file, 3pp., 44KB, About PDF]

Background Documents and Corresponding Presentation(s)

Aromatase Assay

Phase 1 Pre-Optimization Experiments for Substrate Characterization for Porcine Microsomes [PDF file, 6pp., 141KB, About PDF]

Letter Report on Phase 1 Pre-Optimization Experiments for Substrate Characterization for Bovine Placental Microsomes [PDF file, 5pp., 130KB, About PDF]

Letter Report on Phase 1 Pre-Optimization Experiments for Substrate Characterization for Human Recombinant and Human Placental Microsomes [PDF file, 13pp., 1.15MB]

Pre-Validation Study Plan and Protocol for Aromatase Assay Using Human, Bovine, and Porcine Placenta and Human Recombinant Microsomes [PDF file, 18pp., 13KB, About PDF]

Presentation: Aromatase [PPT file, 22pp., 337KB]

Mammalian Two-Generation Study

One-Generation Extension Study of Vinclozolin and Di-n-Butyl Phthalate Administered by Gavage on Gestational Day 6 to Postnatal Day 20 in Sprague-Dawley Rats [PDF file, 69pp., 368KB, About PDF]

Presentation: One-Generation Extension Study of Vinclozolin and Di-n-Butyl Phthalate Administered by Gavage on Gestational Day 6 to Postnatal Day 20 in Sprague-Dawley Rats [PPT file, 63pp., 978KB]

One-Generation Extension Study Results [PPT file, 67pp., 1MB]

EDSP Validation Plan for Mammalian Two-Generation Study [PPT file, 18pp., 1MB]

Mammalian Two-Generation History of Decisions, Background Documents, and Questions for EDMVS [PDF file, 23pp., 307KB, About PDF]

Steroidogenesis Assay

Study Plan to Optimize the Sliced Testis Steroidogenesis Assay - July 25, 2002 [PDF file, 38pp., 1MB, About PDF]

Presentation: Optimization of the Sliced Testis [PPT file, 26pp., 13KB]

Study Plan Figures [PDF file, 5pp., 146KB, About PDF]

Draft Part 1 Letter Report: Optimization of the Sliced Testis Steroidogenesis Assay - May 19, 2003 [PDF file, 52pp., 267KB, About PDF]

Presentation: Prevalidation and Validation Study Plan for Sliced Testes [PPT file, 30pp., 101KB]

Questions of EDMVS on the Steroidogenesis Assay Presentation [PPT file, 9pp., 32KB]

Reflections by EDSP

Presentation: What the EDSP heard from the EDMVS [PPT file, 4pp., 14KB]

Presentation: EDMVS Draft Workplan [PPT file, 23pp., 94KB]

Public Comments

Presentation: American Chemistry Council [PPT file, 16pp., 479KB]

Presentation: Crop Life of America [PPT file, 4pp., 101KB]

Presentation: Comments Regarding Nipples/Areolae Retention Endpoint. Barbara Neal, DABT. BBL Sciences [PPT file, 13pp., 52KB]

Meeting Summary

Meeting Summary [PDF file, 37pp., 536KB, About PDF]


PLEASE NOTE:

Some of the documents presented may not be accessible using alternative access devices. If you need access to these documents please contact William Wooge at 202-564-8476. We will post accessible documents as soon as possible.

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