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Endocrine Disruptor Methods Validation Subcommittee (EDMVS)

Fifth Plenary Meeting - July 23-24, 2002

Agenda

PDF File [2pp., 123KB, About PDF] HTML File [16KB]

Federal Register Notices Announcing Meeting | Copy for Public Comment

Endocrine Disruptor Methods Validation Subcommittee under the National Advisory Council for Environmental Policy and Technology; Notice of Public Meeting [PDF file, 3pp., 44KB, About PDF]

Background Documents and Corresponding Presentation(s)

Mammalian Two-Generation PTU Special Study

Final Report: Two-Generation Reproduction Toxicity Study of Propylthiouracil (PTU) when Administered to Sprague-Dawley Rats in the Drinking Water [PDF file, 130pp., 1.2MB, About PDF]
Note: The PTU Special Study has an appendix that is a 3 Mb Adobe Acrobat Document. This appendix is available upon request due to its size. If you would like this document electronically, please contact Jane Smith at smith.jane@epa.gov or 202-564-8476.

Presentation: Two-Generation Reproduction Toxicity of Propylthiouracil When Administered to Sprague-Dawley Rats in the Drinking Water [PPT file, 17pp., 393KB]

Amphibian Metamorphosis Assay (Tier 1)

Revised Draft Detailed Review Paper [PDF file, 93pp., 424KB, About PDF]

Appendix A - Methods Used in Literature Analysis [PDF file, 86pp., 304KB, About PDF]

Appendix B - Expert Interviews [PDF file, 11pp., 161KB, About PDF]

Presentation: Detailed Review Paper [PPT file, 39pp., 745KB]

Presentation: Development of Model for Detecting Thyroid Axis Disruption [PPT file, 25pp., 46MB]

Questions for EDMVS on the Draft Detailed Review Paper (3 July 2002) [PDF file, 1pp., 63KB, About PDF]

Mysid Life Cycle Assay (Tier 2)

Draft Detailed Review Paper on Toxicity Test [PDF file, 76pp., 475KB, About PDF]

Invertebrate DRP (Tier 2)

Presentation: Advantages of a Two-Generation Mysid Protocol [PPT file, 17pp., 10.8MB]

Presentation: Toxicity Test [PPT file, 28pp., 401KB]

Questions for EDMVS on the Draft Detailed Review Paper on Mysid Life Cycle Test (2 July 2002) [PDF file, 1pp., 73KB, About PDF]

Estrogen Receptor Binding Assays (ER)

ICCVAM - Executive Summary [PDF file, 7pp., 23KB, About PDF]

ICCVAM Transcriptional Activation Assays - Executive Summary [PDF file, 6pp., 20KB, About PDF]

Androgen Receptor Binding Assays (AR)

Androgen Receptor Binding Assays - Executive Summary [PDF file, 6pp., 22KB, About PDF]

ICCVAM Transcriptional Activation Assays - Executive Summary [PDF file, 6pp., 22KB, About PDF]

Presentation: ER & AR Assay: Initial Assumptions [PPT file, 3pp., 14KB]

Presentation: Report on the ICCVAM/NICEATM Expert Panel Meeting on In Vitro ER/AR Assays [PPT file, 41pp., 238KB]

For more information and the complete report on the ER/AR assays see: http://iccvam.niehs.nih.gov/methods/endodocs/ed_brd.htm.Exit Disclaimer

Other Topics

Presentation: Assessing the Impact of Body Weight on Male and Female Pubertal Development [PPT file, 37pp., 354KB]

Presentation: Criteria for Screens - Review of EDSTAC Recommendations [PPT file, 10pp., 54KB]

Presentation: EDMVS Draft Work Plan [PPT file, 22pp., 95KB]

Presentation: Selection of Dose Levels for Mammalian In Vivo Tier 1 Assays: Discussion Points [PPT file, 9pp., 41KB]

Summary and References for Background Literature Addressing Correlations Between Food Restriction and Pubertal Development [PDF file, 3pp., 111KB, About PDF]

Public Comments

Presentation: Comments from EDMVS on Restricted Feeding Study [PPT file, 9pp., 40KB]

Presentation: Comments on In Vitro ER/AR Assays [PPT file, 5pp., 29KB]

Presentation: Comments to EDMVS Concerning Proposed Wildlife Studies [PPT file, 5pp., 31KB]

Presentation: Comments on Dose Setting [PPT file, 15pp., 1MB]

Presentation: Phylogeny Comments [PPT file, 19pp., 436KB

Meeting Summary

Meeting Summary [PDF file, 39pp., 225KB, About PDF]


PLEASE NOTE:

Some of the documents presented may not be accessible using alternative access devices. If you need access to these documents please contact William Wooge at 202-564-8476. We will post accessible documents as soon as possible.

Documents presented on this page may be in Microsoft PowerPoint (PPT), Microsoft Excel (XLS), or Lotus Freelance Format (PRZ). To view or print them you will need to have their associated programs installed on your computer. The programs can be downloaded and used with no charge from the following links.


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