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15-Day Intact Adult Male Rat Assay Peer Review Materials

EPA announced in a July 2007 Federal Register Notice (PDF) (4 pp, 67K, About PDF) the approach it intends to take for conducting peer reviews of the Tier 1 screening assays and Tier 2 testing assays that are being validated.  As described in the Federal Register Notice, peer review materials will be posted as they become available. Materials may include the documents to be peer reviewed, background documents, the charge to the peer reviewers, and reports that summarize the results of peer reviews. Peer review materials for the 15-Day Intact Adult Male Rat Assay can be accessed below:

You will need the free Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more. If you need help accessing these PDF documents, please contact William Wooge at 202-564-8476 or wooge.william@epa.gov for assistance.

Charge to Peer Reviewers

Charge to Peer Reviewers (PDF) (2 pp, 16K)

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Integrated Summary Report

Integrated Sumary Report for Validation of 15-Day Intact Adult Male Rat Assay as a Potential Screen in the Endocrine Disruptor Screening Program Tier-1 Battery (PDF) (223 pp, 2.7M)

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Background Documents

Final Report - Inter-Laboratory Validation of the 15-Day Adult Intact Male Rat Assay with Linuron and Phenobarbital (Charles River Laboratories) (PDF) (458 pp, 17.3M)

Final Report - Inter-Laboratory Validation of the 15-Day Adult Intact Male Rat Assay with Linuron and Phenobarbital (RTI International) (PDF) (479 pp, 16M)

Final Report - Inter-Laboratory Validation of the 15-Day Adult Intact Male Rat Assay with Linuron and Phenobarbital (WIL Research Laboratories, LLC) (PDF) (643 pp, 15M)

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Peer Review Results

Peer Review Results for the 15-Day Intact Adult Male Rat Assay (PDF) (101 pp, 524K)

EPA Response to Peer Review Comments (PDF) (6 pp, 33K)

American Chemistry Council (ACC): Letter - Additional Information Relevant to EPA’s Peer Review of the 15-Day Intact Adult Male Rat
Assay (PDF)
(32 pp, 699K)

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