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Basu, Asit P., Gary F. Krause, Kai Sun, Mark Ellersieck and Foster L. Mayer. 1994. Some Problems of Safe Dose Estimation. In: Environmental Statistics, Assessment, and Forecasting. EPA/600/A-94/200. C. Richard Cothern and N. Phillip Ross, Editors. Lewis Publishers, Boca Raton, FL. Pp. 351-360. (ERL,GB 801). (Also avail. from NTIS, Springfield, VA: PB95-122982)

In this chapter the current status for estimationof "safe doses" in carcinogenic experiments is examined. After considering various definitions of safe doses, a method of standardizing safe doses based on some objective parameters is introduced; and a procedure of estimating standardized safe doses under competing risks is discussed. Examples are given to illustrate how raw data can be analyzed by using the proposed methods.

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