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Inorganic Arsenic Meetings & Webinars

UPDATE: NRC released an Interim Report on inorganic arsenic - November 7, 2013.

EPA is announcing a series of public meetings and webinars on the Integrated Risk Information System (IRIS) Toxicological Review of Inorganic Arsenic. These events are designed to inform the planning for EPA’s toxicological review of chronic exposure to inorganic arsenic (iAs) (cancer and non-cancer effects), which EPA intends to post to the Integrated Risk Information System (IRIS) database.

EPA's IRIS Program is committed to proactively engaging stakeholders, increasing transparency, and using the best available science to develop IRIS assessments. These public meetings offer an ongoing dialogue about IRIS for interested parties and stakeholders. EPA has recently held the following events:

Environmental protection decisions, based in part on EPA's IRIS assessments, can have potentially large impacts on the environment, human health and the economy. Because of this, it is important that EPA benefit from stakeholder and scientific engagement to support the best decisions possible. If you were not able to attend, please take an opportunity to review the presentations included below.

EPA's Planning and Scoping Meeting

Jan 8-9, 2013: Planning and scoping for the development of the IRIS Toxicological Review of Inorganic Arsenic

Meeting Background:

EPA is developing a plan for drafting a new IRIS Toxicological Review of Inorganic Arsenic. The first planning step is determining the scope of the Toxicological Review. The scope transparently communicates why the Toxicological Review is being performed and what it will include or exclude.

The meeting consisted of 5 sessions of panel discussions focused on a series of charge questions. Lead discussants briefly summarized the available data to address the questions and facilitate discussion with other panelists. Once the panel discussion is over, participants attending the meeting in person or remotely via webinar/teleconference were given the opportunity to ask questions or provide comments within the time constraints of the meeting. In addition to discussions after the panel sessions, time was alloted for participants attending the meeting in person or remotely via webinar/teleconference to provide additional comments.

Meeting Materials:

Meeting Objective : 

This workshop gave stakeholders the opportunity to share their views about the scope on the EPA's toxicological review of inorganic arsenic. All meeting participants were given the opportunity to comment on their needs for the Toxicological Review, the current state of scientific information that should be considered when developing the Toxicological Review, and the potential impacts of the Toxicological Review.

Final Reports:

EPA produced a planning and scoping summary (PDF) (2 pp, 206Kb) document at the end of this public workshop.  This planning and scoping summary document aims to communicate how EPA will produce the assessment while meeting the needs of the Agency and the American people.

Related Links:

Information relevant to the development of a toxicological review of iAs include the following publications:

  1. Science and Decisions (NAS, 2009)
  2.  Review of IRIS Formaldehyde Assessment (NAS, 2011)
  3. SAB Reviews of draft iAs Assessments (SAB, 2011; SAB, 2007)
  4. Arsenic in Drinking Water; Arsenic in Drinking Water Update (NAS, 2001; NAS, 1999)
  5. 2005 EPA Cancer Guidelines (including mode of action framework)
  6. 2006/2008 IPCS Mode of Action Framework
  7. EPA’s Risk Characterization Handbook

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National Research Council Meetings:

[UPDATE] The National Research Council announced in a November 7, 2013 NRC Press Release that they have released an Interim Report, called Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic Exit EPA disclaimer, that describes their recommendations to the IRIS Program for developing an updated assessment of inorganic arsenic. The report contains findings and recommendations related to six critical areas, including:

  1. hazard identification;
  2. systematic review;
  3. assessment of causality;
  4. mode of action;
  5. susceptibility; and
  6. dose-response analysis.

See the report in brief (pdf, 2pp, 250Kb). Additional details are available from the NRC iAs Project Information page Exit EPA disclaimer



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Project Start date Jul 17, 2012


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