Mouse Lung Tumor Workshop
NOTICE: Due to the Federal government shutdown, the Mouse Lung Tumor Workshop has been rescheduled to January 7-8, 2014. Additional details will be announced as they become available.
EPA is announcing a State-of-the-Science Workshop on Chemically-induced Mouse Lung Tumors: Applications to Human Health Assessments. The purpose of this workshop is to discuss the available data and interpretation of results from studies of mouse bronchiolar-alveolar adenomas and carcinomas (lung tumors) following exposure to chemical agents, and the relevance of such tumors in mice to human cancer risk. Several lines of research have investigated whether or not these types of lung tumors are formed by a mode of action (MOA) which is specific to mice and are relevant to tumor formation or other toxicity in humans.
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EPA's Mouse Lung Tumor Workshop (MLTW) will be held on from 8:30 AM - 5:00 PM eastern time on January 7-8, 2014.
US EPA Auditorium (Room C111)
109 TW Alexander Drive
Research Triangle Park, NC 27711
This two-day, state-of-the-science workshop will cover a broad range of evidence from human, animal, and in vitro studies with a focus on specific chemicals (ethylbenzene, naphthalene, and styrene) causing lung tumors in mice and implicated in a proposed species-specific mode of action (MOA) based on metabolic and physiological susceptibility. The workshop is being sponsored and organized by EPA with input from (1) a volunteer committee of outside experts (including representatives from academic institutions, State agencies, other Federal organizations, NGOs, and industry), and (2) an internal working group of experts from EPA and other Federal partners. The workshop will include four separate sessions that will examine individual topic areas in detail, beginning with and continually referring back to the human relevance of data from animal and in vitro studies.
Workshop Goals and Scope:The goals of this workshop are to:
- Identify the evidence, from multiple scientific disciplines, regarding formation of chemically-induced lung tumors in mice and how such evidence informs human health assessments.
- Identify approaches for analyzing and interpreting the evidence.
- Identify commonalities, linkages, or differences between the evidence from various disciplines.
Prior to the workshop:
- Review the Session Abstracts (PDF) (55pp, 1.2M). These abstracts provide context for and define the scope of the discussions. These materials will help participants engage in discussions from the beginning of the workshop and will reduce the need for overview presentations at the workshop.
- Visit the Health and Environmental Research Online (HERO) project page (http://hero.epa.gov/mltw/). The HERO project page provides a list of relevant reference materials.
- Register for the meeting. Registration prior to the workshop is required for those participating both in person and by webinar/teleconference. (see Workshop Registration).
During the workshop:
- A panel of 10-12 experts from academia, industry, and government will review the available scientific knowledge on the proposed subject areas listed in the Agenda.
- Members of the public are invited to attend the workshop as observers and to participate in open discussion periods.
- ICF International, Inc. will provide support and planning services related to this workshop, including providing Workshop Registration.
After the workshop:
- A summary report of the workshop proceedings will be developed.
- Review articles will be developed for publication in peer-reviewed journals.
- Post-workshop meetings will continue discussions related to the goals of the workshop.