Jump to main content or area navigation.

Contact Us

Integrated Risk Information System (IRIS)

Process for Developing IRIS Health Assessments

IRIS Process Diagram - 2009 Update

IRIS Process Diagram—2013 Update (PDF) (7 pg, 156 Kb)

In July 2013, EPA announced enhancements to the IRIS assessment development process. These enhancements will improve productivity and scientific quality in IRIS assessments and help EPA meet the goal of producing IRIS assessments in a timely and transparent manner. Highlights include: a public problem formulation meeting before beginning to develop an IRIS assessment; release of preliminary materials early in the assessment development process with a public meeting to hear comments on the materials; flexibility to revise draft assessments as needed after hearing the public’s comments prior to peer review; stopping rules (PDF) (2pp, 68 Kb) for incorporating new data and raising scientific issues, and strengthened practices for peer review (PDF) (4pp, 814Kb).

The process for developing an IRIS assessment consists of:

EPA conducts a comprehensive search of the scientific literature and develops a draft IRIS health assessment. During this step, EPA will hold a public problem formulation meeting before beginning the assessment; release preliminary materials (literature search strategies, evidence tables, and exposure-response figures); and hold a public meeting. Public meetings will be announced on the IRIS website.

EPA-wide internal review of the draft assessment.

Science consultation on the draft assessment with other Federal Agencies and the Executive Office of the President.

The draft assessment is released for public review and comment and independent expert peer review. The draft assessment and draft peer review charge are posted to IRIS website. During this step, EPA will hold a public meeting to discuss the draft assessment and draft peer review charge. In some cases, the IRIS Program may revise the draft assessment and peer review charge after hearing the public’s comments about these materials.  Also during this step, the external peer review meeting occurs. EPA will announce in a Federal Register Notice and on the IRIS website the availability of the draft assessment, draft peer review charge, public meeting date, and peer review meeting dates.

EPA addresses the peer review and public comments and prepares a response to comments document.

Science feedback on the final assessment from EPA-wide internal review and science discussion with other Federal Agencies and the Executive Office of the President.

The final assessment, including the IRIS Summary, Toxicological Review, and response to public and external peer review comments, is posted to the IRIS website.

See diagram to right for additional details and the specific steps in the IRIS process.

IRIS Improvements:

Recent developments in the IRIS Program include:


History of the IRIS process for developing assessments

 

  • 2008 IRIS Process for Developing IRIS Assessments -
    In 2008, the IRIS process consisted of developing a draft Toxicological Review for the chemical, conducting internal and external scientific reviews of the draft document, responding to review comments, and developing and posting on the IRIS website an IRIS Summary and final Toxicological Review. Additionally, new steps in the process included increased participation by other federal agencies and the public in developing the Toxicological Review and opportunities for other federal agencies to conduct research to fill data gaps. For additional information refer to the 2008 IRIS process.
  • 2004-2008 IRIS Process for Developing IRIS Assessments -
    From 2004 to 2008, the IRIS process consisted of developing a draft Toxicological Review for the chemical, conducting internal and external scientific reviews of the draft document, responding to review comments, and developing and posting on the IRIS website an IRIS Summary and final Toxicological Review. Additionally, new steps in the process included increased participation by other federal agencies and the public in developing the Toxicological Review and opportunities for other federal agencies to conduct research to fill data gaps. For additional information refer to the 2004-2008 IRIS process.
  • Pre-2004 IRIS Process for Developing IRIS Assessments -

    Before 2004, the IRIS process consisted of developing a draft Toxicological Review for the chemical, conducting internal and external scientific reviews of the draft document, responding to review comments, and developing and posting the final assessment on the IRIS website. For additional information refer to the Pre-2004 IRIS process.

 

Recent Additions | Advanced Search | IRIS Home | NCEA Home | ORD Home

Jump to main content.