Computational Toxicology Research Program

Tox21

Tox21 is a collaboration between EPA, National Institutes of Environmental Health Sciences/National Toxicology Program, National Institutes of Health/National Human Genome Research Institute , NIH Chemical Genomics Center (NCGC) and the Food and Drug Administration that works together to:

Through a Memorandum of Understanding, research, develop, validate and translate innovative chemical testing methods that characterize toxicity pathways (pdf, 7pp, 60kb)
Research, develop, validate and translate innovative chemical testing methods that characterize toxicity pathways.
Research ways to use new tools to identify chemical induced biological activity mechanisms.
Prioritize which chemicals need more extensive toxicological evaluation.
Develop models that can be used to more effectively predict how chemicals will affect biological responses.
Identify chemicals, assays, informatic analyses, and targeted testing needed for the innovative testing methods.
Conduct 50 or more ToxCast™ high-throughput screening assays on this enlarged chemical library every year for the next several years.
Be able to provide the data generated from the innovative chemical testing methods to risk assessors to use when making decisions about protecting human health and environment.
Currently screening over 10,000 chemicals at the NIH Chemical Genomics Center (View Chemical List)