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Computational Toxicology Research Program

ExpoCast™

Exposure science is the bridge between the sources of chemical, physical, and biological agents and human health. It is used to estimate real-life risks to health and to identify the most effective ways to reduce these risks. EPA's Computational Toxicology Research Program advances characterization of the exposure required to translate findings in computational toxicology to support risk assessment through its ExpoCast research project.

ExpoCast™:

  • Works with EPA's ToxCast tool to help determine priority chemicals that may need further screening or to be regulated.
  • Develops novel approaches for evaluating chemicals based on potential for biologically relevant human exposure.
  • Collaborates with stakeholder groups to mine and apply scientific advances and tools in a broad range of fields.
  • Includes two main focus areas, 1) Prioritization tools and 2) Translation tools
  • The prioritization tools under development include public accessible and searchable exposure databases and an exposure screening tool for accelerated chemical prioritization.
  • The translation tools under development are systems exposure science, biologically-relevant exposure metrics and environmental informatics and advanced computational models.

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