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ExpoCast™ Program
The ExpoCast™ program is being initiated to ensure the required exposure science and computational tools are ready to address global needs for rapid characterization of exposure potential arising from the manufacture and use of tens of thousands of chemicals and to meet challenges posed by new toxicity testing approaches. The overall goal of this project is to develop novel approaches and tools for screening, evaluating and classifying chemicals, based on the potential for biologically-relevant human exposure, to inform prioritization and toxicity testing. An emphasis will be placed on conducting research to mine and translate scientific advances and tools in a broad range of fields to provide information that can be used to support enhanced exposure assessments for decision making and improved environmental health.
ExpoCast™ will provide an overarching framework for the science required to characterize biologically-relevant exposure in support of the Agency computational toxicology program. Broadly and long-term, the ExpoCast™ program will foster novel exposure science research to (1) inform chemical prioritization, (2) understanding the systems response to chemical perturbations resulting from environmentally relevant exposures and how these translate to relevant biological changes at the individual and population levels, (3) link information on potential toxicity of environmental contaminants to real-world health outcomes.