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ToxCast™ Data

The most updated publicly available ToxCast data can be downloaded below. The data is organized into six types of data and includes descriptions of ToxCast chemicals and assays as well as files summarizing the screening results from ToxCast (high-throughput data from ~1,800 chemicals), a MySQL database to download and run locally on a computer, EPA’s analysis of the chemicals screened through the federal Toxicity Testing in the 21st century (Tox21) partnership and available data generated from existing animal toxicity studies. A README file is included for most of the data below and users are encouraged to read this file to help them use the data.


Data Set Description Download
MySQL Database A MySQL database that interacts with a beta version of the R software package which provides access to all ToxCast high-throughput in vitro data. Also includes an overview presentation of the pipeline used to process and analyze the ToxCast data and the R package.

What does this zip file include - README File?

ToxCast Data Pipeline Overview

Download MySQL Database Zip File

Download R Package Zip File

ToxCast Chemicals

(Distributed Structure-Searchable Toxicity Database –DSSTox files)
Chemical details for 8,599 unique substances (GSIDs) and DSSTox standard chemical fields (chemical name, CASRN, structure, etc) for EPA ToxCast chemicals and the larger Tox21 chemical list. Also includes chemical mapping files and quality control grades for chemicals.

What does this zip file include - README File?

ToxCast Chemicals: Data Management & Quality Considerations Overview

Download Zip File
ToxCast Assay Annotation Files ToxCast high-throughput assay descriptions including assay annotation user guide, assay target information, and study design information.

Assay Annotation User Guide

Download Zip File
ToxCast Assay Quality Statistics Quality statistics on the assays (detailed & summary).

What does this zip file include - README File?

Download Zip File
ToxCast Summary Files Data for a single chemical endpoint pair for more than 1,800 chemicals and 821 assay endpoints for 20 variables such as the activity or hit call, activity concentrations, whether the chemical was tested in a specific assay, etc.

What does this zip file include - README File?

Download Zip File
ToxCast Concentration Response Plots Concentration response plots for all of the ToxCast assays. Download Zip File
Tox21 Data EPA’s analysis of the chemicals screened through the federal Toxicity Testing in the 21st century (Tox21) which includes EPA’s activity calls from the screening of 8,599 Tox21 unique substances in the robotic screening.

What does this zip file include - README File?

Download Zip File
Animal Toxicity Studies: Effects & Endpoints (Toxicity Reference Database – ToxRefDB files) Provides the No Effect Level (NEL)/Lowest Effect Level (LEL) and/or No Observed Adverse Effect Level (NOAEL)/Lowest Observed Adverse Effect Level (LOAEL) across the thousands of animal toxicity studies.

What does this zip file include - README File?

Download Zip File

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