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Computational Toxicology Research Program

International Workshop on Uncertainty and Variability in Physiologically Based Pharmacokinetic (PBPK) Models

Meeting Agenda

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TUESDAY, OCTOBER 31 (Day 1 - morning)

8:00 - 9:00 amRegistrationAuditorium Entrance
Plenary SessionAuditorium A & B (C111 A & B)
9:00 - 9:10 WelcomeWeihsueh Chiu
9:10 - 9:30 Getting Serious About Uncertainty and VariabilityGeorge Gray
US EPA
9:30 - 10:00Overview of PBPK Modeling and Its Value in Risk Assessment
Download presentation (PDF, 26 pp., 310 KB)
Harvey J. Clewell, III
CIIT
10:00 - 10:30Experimental Data Used with PBPK Models
Download presentation (PDF, 21 pp.,368 KB)
Hugh A. Barton
US EPA
10:30 - 11:00BREAK
11:00 - 11:30Mediating the Meeting between Model and Data: Statistical Issues for PBPK Modeling
Download presentation (PDF, 21 pp., 612 KB)
R. Woodrow Setzer
US EPA
11:30 - NoonUncertainty and variability in PBPK models: How do we put it all together for risk assessment?
Download presentation (PDF, 24 pp., 513 KB)
Weihsueh Chiu
US EPA
NoonWhat's Next?R. Woodrow Setzer
Noon - 1:00 pmLUNCH

TUESDAY, OCTOBER 31 (Day 1 - afternoon)

Breakout Groups
Group 1: Model SpecificationChairs:
Hugh Barton
Sean Hays
Rapporteur:
Bob MacPhail
C113
Group 2A: Model CalibrationChair:
Woody Setzer
Rapporteur:
John Bailer
Auditorium A (C111A)
Group 2B: Model CalibrationChair:
Chris Portier
Rapporteur:
Rob DeWoskin
Auditorium B (C111B)
Group 3: Model PredictionsChair:
Rory Conolly
Rapporteur:
Weihsueh Chiu
Auditorium C (C111C)
Breakout Groups
1:00 - 2:00 pmGroup 1: Data from controlled human exposure as basis for PBPK modeling of variability
Download presentation (PDF, 29 pp., 500 KB)
Gunnar Johanson
Karolinska Institute
C113
Discrepancies and Discovery: The Value of PBPK Modeling for Insuring Humility
Download presentation (PDF, 28 pp., 664 KB)
Melvin Andersen
CIIT
Group 2A&B: Calibration
Title: Statistical Population Modeling and Analysis of PK Data
Download presentation (PDF, 35 pp., 817 KB)
Marie Davidian
Dept. Statistics, North Carolina State University
Auditorium A&B (C111A&B)
Group 3: Accounting for Uncertainty and Variability in PBPK Modeling Predictions: Where are We Now, Where should We Go?
Download presentation (PDF, 12 pp., 84 KB)
Frédéric Bois
INERIS (Institut National de L'Environnement Industriel et des Risques).
Auditorium C (C111C)
2:00 - 3:00Comments on White Papers by Invited ParticipantsEach Breakout Group
3:00 - 3:30BREAK
3:30 - 5:00 Charge Question DiscussionsEach Breakout Group

WEDNESDAY, NOVEMBER 1 (Day 2)

8:00 - 10:30Charge Question DiscussionsEach Breakout Group
10:30 - 11:00BREAK
11:00 - 12:30Plenary: Report Outs From Breakout GroupsRapporteurs (15 min each + 5 for questions)Auditorium A & B (C111 A & B)
12:30 - 1:30 LUNCH
1:30 - 3:30 Charge Question DiscussionsEach Breakout Group
3:30 - 4:00BREAK
4:00 - 5:00Tours of EPA Facility (Limited to 30 people)Auditorium Lobby (sign-up required)
4:00 - 5:00Breakout Chairs, Rappoteurs Prepare Report Outs for Day 3

THURSDAY, NOVEMBER 2 (Day 3)

8:00 - 10:00 amBreakout Group Report Outs
 Download Group 1 Report (PDF, 12 pp., 164 KB)
 Download Group 2a Report (PDF, 12 pp., 230 KB)
 Download Group 2b Report (PDF, 13 pp., 77 KB)
 Download Group 3 Report (PDF, 28 pp., 53 KB)
Rapporteurs (20 min each + 10 for questions)Auditorium A & B (C111 A & B)
10:00 - 10:30BREAK
10:30 - 12:00Plenary Discussion: Next StepsAuditorium A & B (C111 A & B)

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