Computational Toxicology Research Program

v-Liver™ Concept

Large-scale computer model of the complex "wiring diagram" of dynamic liver processes.
Developed model will include essential components of liver function and their connecting circuitry that scientists have been studying for decades and new connections discovered through innovative new biotechnology and computer hardware/software.
Long-term v-Liver™ will "simulate" the response of the human liver to chemicals and examine these effects in susceptible subpopulations, such as younger or older individuals or those with variations (ie., polymorphisms) in the genes involved in metabolism.
Help scientists understand the importance of different factors leading to liver injury in humans.
Project will develop tools that will be useful in modeling toxicity in other organs