Benchmark Dose Software (BMDS)
Benchmark Dose Modeling – Advanced Topics
Organizers: J. Allen Davis
Instructors: J. Allen Davis, MSPH, US Environmental Protection Agency (EPA); Jeff Gift (EPA); Jay Zhao, MD, MPH, PhD (EPA)
Registration Fee: TBA
Preliminary Date: December 12th, 2013
The objectives of this full-day course are to provide participants with training on how to use EPA’s Benchmark Dose Modeling Software (BMDS) and other software programs to facilitate advanced BMD analyses in risk assessments. Specifically, this course will demonstrate how to use the following advanced BMD models, and will provide fundamental understanding of the approach and model-framework used for the models:
- The MS_Combo model for assessing the risk of developing any number of independent tumors in a single bioassay
- The Multistate Weibull Time-to-Tumor (MSW) model for cancer analyses when survival rates are observed to differ due to exposure
- The Toxicodiffusion model for analyzing repeated response data common to many neurotoxicity test guidelines
- Categorical Regression (CatReg) modeling for analyzing data for multiple endpoints from multiple bioassays and multiple species simultaneously
Participants are expected to have a general understanding of basic benchmark dose methods, either through work-related experience, or previous completion of at least the introductory portion of online training courses (http://epa.gov/ncea/bmds/training/index.html).
Participants need to bring their own laptops to the workshop with BMDS 2.4, the Multistage Weibull executable, CatReg 2.1, and the R statistical package installed (with necessary administrative rights). The latest version of the software programs can be found at: http://epa.gov/ncea/bmds/, epa.gov/ncea/catreg, and http://www.r-project.org/. Specific installation instructions for the software programs can be found on the websites or in documentation that can be downloaded from the websites.
Please check back for updated registration and course information.