Richard Auten is Professor of Pediatrics at Duke University, and co-director of the EPA-funded Children’s Environmental Health Center, the Southern Center for Environmentally Driven Disparities in Birth Outcomes, at Duke University. He is a neonatologist at Duke’s neonatal intensive care unit. His research interests for the last twenty years have focused on the oxidative, inflammatory, and environmental disruptors of post-natal lung development and function, chiefly aimed at the prevention of bronchopulmonary dysplasia, a complication of prematurity that increases the risk to develop asthma. Recent work in his laboratory using rodent models has focused on the effects of combined air pollutants and other stressors during pregnancy and the immediate postnatal period on pulmonary structure and function. Most recently the research group has extended these investigations to the impacts on neurocognitive development and behavior.Before joining the faculty of Duke University in 1990, he completed a fellowship in Neonatal-Perinatal Medicine at the University of Rochester where he also obtained his training in pediatrics. Prior to his sub-specialty training he was a practicing pediatrician in Tarboro, NC. He received his A.B. in chemistry and medical degrees from the University of North Carolina at Chapel Hill.
Dr. Biswal’s program focuses on development of Nrf2-targeted therapeutic intervention for exacerbation of COPD. There are two preclinical projects and one clinical project, all centered on sulforaphane mediated activation of Nrf2 pathway for treatment and prevention of COPD exacerbation. As a PI on several NIH-funded grants, Dr. Biswal laid the groundwork for the proposed translational program project by establishing the field of Nrf2 as a therapeutic target for COPD as well as sulforaphane as a potential drug candidate for this pathway in COPD. In last 10 years, Dr. Biswal’s laboratory has done the seminal translational research that provided the link between defect in Nrf2 with progression of COPD lungs and cigarette smoke induced emphysema in mouse models. Dr. Biswal’s laboratory was first in reporting the overarching induction of multitudes of antioxidant genes and detoxification pathways by nrf2 activation by sulforaphane and its ability to activate antibacterial defenses and phagocytosis in macrophages from COPD patients and mouse models. Dr. Biswal’s laboratory has created the genetically modified mouse models for Nrf2 and Keap1 and biomarkers for efficacy of sulforaphane in COPD which are the key element for drug development in this program. Dr. Biswal has been a PI on several projects as a part of PPGs (SCCOR, SPORE, DISCOVER, Children Asthma Center, CADET) and U clinical trial grant that have provided him a wealth of experience in collaborating with different basic and clinical investigators to solve complex problems and develop translational strategies on nrf2 pathway.
Dr. Bradman is an environmental health scientist who focuses on exposures to pregnant women and children. He worked with Dr. Brenda Eskenazi to co-found the Center for Environmental Research and Children's Health (CERCH) at the University of California, Berkeley, in 1997 and helps direct biomonitoring and exposure studies as part of the CHAMACOS partnership in the Salinas Valley, California. He is co-Principal Investigator of the National Children's study in Kern County, CA, and also leads an initiative to improve environmental health in California child care facilities.
Kim Boekelheide is Professor of Pathology and Laboratory Medicine at the Brown University School of Medicine. He received his B.A. from Harvard University, and M.D. and Ph.D. from Duke University. His research examines fundamental molecular mechanisms by which environmental and occupational toxicants induce testicular injury. Current projects include the study of co-exposure synergy using model testicular toxicants and the effects of in utero endocrine disruptor exposure on steroidogenesis and a predisposition to cancer. He is Director of the Brown University Superfund Research Program and the Children's Environmental Health Formative Center. His research has been continuously funded by the National Institute of Environmental Health Sciences since 1985 and currently a member of the National Advisory Environmental Health Sciences Council.
Dr. Buffler is a Professor of Epidemiology (and Dean Emerita) at the University of California (UC), Berkeley, School of Public Health. She holds an adjunct faculty position at the UC San Francisco (UCSF), School of Medicine and is an affiliate member of the UCSF Comprehensive Cancer Center. She is an internationally known cancer epidemiologist with considerable experience in epidemiologic investigations of childhood cancers and environmental exposures. She has served on the Board of Scientific Counselors for the Agency for Toxic Substance and Disease Registry (ATSDR), the National Institute for Occupational Safety and Health (NIOSH), the Mine Health and Safety Administration (MSHA), the National Center for Infectious Diseases and the National Advisory Council for the NIEHS. Dr. Buffler is an elected member of the Institute of Medicine National Academy of Sciences and was elected to the American Epidemiological Society and to fellowship in the American Association for the Advancement of Science for her contributions to epidemiology. She has served as President for the Society for Epidemiologic Research, the American College of Epidemiology and one of the founding Presidents of the International Society for Environmental Epidemiology. Currently she is serving as a member of the Executive Committee for the International Epidemiological Association. She has received numerous honors including the Lilienfeld Award from the American College of Epidemiology in 1996, and the Bruce Award from the American College of Physicians/ American Society of Internal Medicine in 1998. Dr. Buffler is a highly accomplished investigator in cancer epidemiology. For the past 15 years, her research focus has been on the epidemiology of childhood cancers. As the Principal Investigator (PI), she has successfully conducted the Northern California Childhood Leukemia Study (NCCLS) since 1995. The NCCLS is a NIEHS-funded, multi-institutional comprehensive molecular epidemiology study of childhood leukemia (R01 ES009137-08 and P47 ES04705-20), that pioneered the use of a multidisciplinary approach to study the molecular, toxicologic, genetic, environmental and epidemiologic factors related to the development of childhood leukemia. Dr. Buffler’s experience in the conduct of large multi-institutional and multi-disciplinary epidemiology studies, her expertise in childhood cancers, both nationally and internationally, her recognition in various settings (i.e., academic, research, regulatory agencies), and her impressive track record of publications demonstrate her ability to successfully lead the activities for the UC Berkeley subaward on the proposed project.
Dr. Diette is Professor of Medicine, Epidemiology and Environmental Health Sciences at the Johns Hopkins University. He is a pulmonologist with a practice devoted to the care of patients with obstructive lung diseases, including asthma and COPD. He has an extensive portfolio of patient-based research in asthma and COPD, supported by the NIH and other sponsors. Dr. Diette's current research focuses on identifying environmental causes of obstructive lung diseases, the role of diet in development of asthma, as well as understanding and reducing disparities in health of racial and ethnic minorities.
Dr. Diette received his undergraduate degree in Economics from the Wharton School of the University of Pennsylvania, the Doctor of Medicine degree from Temple University and a Master's degree in Epidemiology from the Bloomberg School of Public Health at Johns Hopkins University. He completed a residency in Internal Medicine at the Hospital of the University of Pennsylvania and fellowship training in Pulmonary and Critical Care Medicine at Johns Hopkins Hospital.
Dr. Dolinoy serves as the John G. Searle Assistant Professor of Environmental Health Sciences at the University of Michigan School of Public Health (UM SPH). Dr. Dolinoy leads the Environmental Epigenetics and Nutrition Laboratory, which investigates how nutritional and environmental factors interact with epigenetic gene regulation to shape health and disease. Her laboratory is using state-of-the-art technology to investigate the role of early exposures on epigenomic profiles in the mouse and human in order to identify species, dose, and tissue specific alterations in DNA methylation and histone profiles associated with metabolic disorders later-in-life. Dr. Dolinoy serves as an investigator in the EPA/NIEHS-funded Formative Children’s Environmental Health and Disease Prevention Center (P20 ES018171-01/RD834800) on perinatal exposures, epigenetics, child obesity & sexual maturation, investigating early exposure to BPA, lead, and phthalates, epigenetics, and later-in-life body weight and hormone outcomes. She also plays a leadership role in UM’s NIEHS P30 Core Center, Lifestage Exposures and Adult Diseases (P30 ES017885), and serves as a member of the Children’s Working Initiative of the University of Michigan Institute for Clinical and Health Research (MICHR) Clinical and Translational Science Award.
Dr. Faustman is Professor in the Department of Environmental and Occupational Health Sciences at the University of Washington School of Public Health and Community Medicine and Director of the Institute for Risk Analysis and Risk Communication. She is Co-PI of the NIEHS and NSF funded Pacific Northwest Center for Human Health and Ocean Studies at UW and Director of the Reproductive and Developmental Research Core of the UW Center for Ecogenetics and Environmental Health.
Dr. Gruppuso is a Professor of Pediatrics and a Professor of Molecular Biology, Cell Biology and Biochemistry (Research) at Brown University. He is also the Associate Dean for Medical Education at the Warren Alpert Medical School of Brown University. As a pediatric endocrinologist, his longstanding research focus has been the regulation of fetal and postnatal somatic growth. In recent years, his work has focused on understanding the mechanisms by which nutrients regulate cell cycle progression, translation, and gene expression.
Dr. Hammond is Professor and former Chair of Environmental Health Sciences at the University of California, Berkeley. Her research has focused on assessment of exposure for environmental and occupational epidemiologic studies, including studies of the health effects of air pollution, diesel exhaust, secondhand smoke, semiconductor wafer production, and automobile manufacturing. Occupational studies in progress include the Bay Area Solvent Study, which is examining the relationship between solvent exposure and neurologic and reproductive effects in automotive mechanics, and a study of cardiovascular effects of work in aluminum production. A combination of her chemistry, industrial hygiene and epidemiology background enable her to develop innovative techniques to measure airborne contaminants and evaluate exposures. Currently she heads the exposure assessment team for the Fresno Asthmatic Children’s Environment Study (FACES) and the Children’s Health and Air Pollution Study in the San Joaquin Valley (CHAPS- SJV).
Dr. Hansel is Associate Professor of Medicine in the Division of Pulmonary and Critical Care Medicine at Johns Hopkins with joint appointments in the Division of Allergy and Clinical Immunology at the Johns Hopkins School of Medicine and the Department of Environmental Health Sciences at the Johns Hopkins Bloomberg School of Public Health. She received her medical degree from Harvard Medical School and her Masters of Public Health Degree from the Johns Hopkins Bloomberg School of Public Health. Dr. Hansel is a skilled pulmonary physician with extensive experience treating patients of diverse ethnic backgrounds with COPD and asthma. She has devoted her career to the studies of genetic and environmental determinants of obstructive lung diseases. Dr. Hansel is Principal Investigator on several studies evaluating environmental determinants of obstructive airway diseases.
Kim Harley, Ph.D. is an Associate Adjunct Professor of Maternal and Child Health at the University of California, Berkeley. She is a reproductive and perinatal epidemiologist whose research focuses on the association between endocrine disrupting chemicals and child development, including neurodevelopment, obesity, and onset of puberty. Her work has focused on the reproductive and developmental effects of Bisphenol A, PBDEs, DDT, and organophosphate pesticides. Dr. Harley has spent several years investigating the effects of environmental chemical exposures to mothers and children living in a migrant farm worker community. She is an Associate Director of the CHAMACOS Study, a longitudinal cohort study of Latina mothers and children living in the agricultural Salinas Valley, California. Children in the CHAMACOS study have been followed from before birth until 12 years of age to determine the impact of environmental exposures on their growth, neurodevelopment, and health. Dr. Harley is the principal investigator of grant to examine the role of early life BPA exposure on children's health and development in this cohort.
Dr. Hertz-Picciotto, is Chief of the Division of Environmental Health, and Professor of Epidemiology, MIND (Medical Investigations of Neurodevelopmental Disorders) Institute at the University of California, Davis. She is an internationally renowned environmental epidemiologist with more than 200 scientific publications addressing environmental exposures, including metals, pesticides, air pollutants and endocrine disruptors; their interactions with nutrition; and their influences on pregnancy, the newborn and child development. In 2002, she turned her attention to autism, launching the CHARGE Study, the first large, comprehensive population-based study of environmental factors in autism, and a few years later, MARBLES (Markers of Autism Risk in Babies – Learning Early Signs), to search for early environmental and biologic predictors of autism, starting in pregnancy. She also collaborates on the multisite EARLI study, and is Director of the Northern California Center for the National Children’s Study. Dr. Hertz-Picciotto sits on editorial boards for four major scientific journals in epidemiology, environmental health, and autism, including as Associate Editor of Environment International, and has held appointments on state, national and international advisory panels to organizations such as the Food Safety in Europe Working Group, U.S. Environmental Protection Agency, National Toxicology Program, California Air Resources Board, and National Institutes of Health Interagency Coordinating Committee on Autism Research. She has been elected President of two of the largest professional epidemiology societies; chaired the Expert Panel on Centers for Disease Control and Prevention’s Vaccine Safety Database for Studies of Autism and Thimerosal; chaired National Academy of Sciences Panels on Agent Orange and Vietnam Veterans and more recently the Institute of Medicine Committee on Breast Cancer and the Environment. Dr. Hertz-Picciotto has taught epidemiologic methods on four continents and mentored 60 doctoral and postdoctoral scholars. This year, she received the Goldsmith Lifetime Achievement Award by the International Society for Environmental Epidemiology.
Dr. Margaret Karagas received her PhD in epidemiology from University of Washington after which she joined the Dartmouth faculty where she heads the Section of Biostatistics and Epidemiology in the Department of Community and Family Medicine at Geisel School of Medicine at Dartmouth. She is currently Director of the formative Children’s Environmental Health and Disease Prevention Research Center at Dartmouth and Co-Director of the Cancer Epidemiology and Chemoprevention Program in the Norris Cotton Comprehensive Cancer Center. She has served on numerous committees including the International Agency for Research on Cancer’s monograph on arsenic and other drinking water contaminants; Board of Scientific Counselors for the National Toxicology Program; National Academy of Sciences Analysis of Cancer Risks in Populations near Nuclear Facilities; and the European Food Safety Authority Scientific Opinion on Arsenic in Foods. Her work encompasses interdisciplinary studies designed to illuminate the pathogenesis of human disease beginning early in life, and impacting health throughout the lifespan. Her ongoing research determining the effects of common environmental levels of arsenic exposure on cancer risk motivated her recent focus on in utero and early life exposure to these contaminants, sources of exposure and their effects on children’s health through formative Dartmouth Children’s Center.
Catherine Metayer a physician trained in France. She worked as an intern in departments of pediatrics and oncology where she developed an interest in cancer research. She received her PhD in Epidemiology at Tulane University, New Orleans, LA, and focused her post-doctoral work on occupational exposures related to hematopoietic cancers in adults. She was a Visiting Scientist at the Division of Epidemiology & Genetics at the National Cancer Institute, Bethesda, expanding her research on secondary cancers following treatment for a primary cancer, and environmental risk factors of lung cancer in China. She is currently an Associate Adjunct Professor at UC Berkeley, School of Public Health, working on environmental and genetic factors of childhood leukemia in California and within the Childhood Leukemia International Consortium (CLIC).
Dr. Miller is the Associate Professor of Medicine (in Pediatrics) and Environmental Health Sciences at Columbia University. She is the Director of the Allergy and Immunology Fellowship Program. She also is Co-Deputy Director, Asthma Project Director for the Columbia Center for Children's Environmental Health and the Associate Director and Lead Physician Scientist, Disease Investigation through Specialized Clinically-Oriented Ventures in Environment Research (DISCOVER) initiative sponsored by NIEHS. Her research focuses on understanding the causes of asthma.
Dr. Kari Nadeau is Associate Professor of Pediatrics—Immunology and Allergy, and Associate Professor of Otolaryngology at Stanford University School of Medicine. She received her Bachelor of Science degree from Haverford College, an M.D. degree from Harvard Medical School and her Ph.D. from Harvard University in Biochemistry. The goal of the research in Dr. Nadeau's laboratory at Stanford is to investigate the role of ambient air exposure on the developing immune system in children, with a focus on understanding the interaction between environment and the immune system by studying detailed mechanistic studies in T cells. Dr. Nadeau has a broad background in immunology, with specific training and expertise in key research areas on T cells. She is working with Drs. Katharine Hammond and Ira Tager at the University of California, Berkeley, to link mechanistic immunology studies with epidemiological outcomes of ambient air pollution exposure. Dr. Nadeau has published more than 71 peer-reviewed papers, many of which focus on T cells and health outcomes.
Dr. Frederica P. Perera, Dr.P.H. is a professor at Columbia University’s Mailman School of Public Health, where she serves as director of the Columbia Center for Children’s Environmental Health and of the DISCOVER (Disease Investigation Through Specially Clinically-Oriented Ventures in Environmental Research Center) Dr. Perera is a widely recognized expert in the field of children’s environmental health and internationally recognized for pioneering the field of molecular epidemiology, beginning with studies of cancer. She and her colleagues are applying advanced molecular and imaging techniques within longitudinal cohort studies of pregnant women and their children, with the goal of identifying preventable risk factors for developmental disorders, asthma, obesity and cancer in childhood. Dr. Perera received her undergraduate degree from Radcliffe/Harvard University and her Masters and doctoral degrees in Public Health from Columbia University. Her areas of specialization include prevention of environmental risks to children, molecular epidemiology, disease prevention, environment-susceptibility interactions, and risk assessment. She is the author of more than 200 publications and has received numerous honors, including: First Irving J. Selikoff Cancer Research Award, The Ramazzini Institute (1995); Newsweek, The Century Club Award (1997); First Children’s Environmental Health Award, The Pew Center for Children’s Health and the Environment (1999); Distinguished Lecturer, National Cancer Institute, Occupational and Environmental Cancer (2002); Doctoris Honoris Causa, Jagiellonian University, Krakow, Poland (2004); Children’s Environmental Health Excellence Award, U.S. Environmental Protection Agency (2005); and CEHN (Children’s Environmental Health Network) Award (2008).
Dr. Pessah obtained his B.S. in Biological Sciences from Cornell University (1977) and his Ph.D. in Toxicology from the University of Maryland in 1984. He was a Postdoctoral Fellow at the University of California (UC) at Berkeley from 1984 to 1987, during which time he discovered a family of calcium channels termed ryanodine receptors. Since then, his research and academic interests have spanned the broad area of molecular and cellular mechanisms by which these channels regulate Ca2+ signaling in muscle, neurons and immune cells. He studies the organization and function of the macromolecular complexes regulating ryanodine-sensitive Ca2+ channels and how environmental chemicals, including PCBs, PBDEs, reactive quinone metabolites, pesticides and heavy metals influence developmental toxicity through these complexes. Members of his laboratory have been studying gene-environment interactions influencing susceptibility that are relevant to autism and related disorders using mice possessing missense mutations known to contribute susceptibility to human disease. He directs the UC Davis Center for Children’s Environmental Health and Disease Prevention. The Center is an NIEHS/US EPA funded multidisciplinary program aimed at understanding how environmental factors influence autism risk and severity. He is Professor of Toxicology and Chair of the Department of Molecular Biosciences. In addition, he is Associate Editor of NeuroToxicology, and a Board Reviewer for Environmental Health Perspectives, Journal of Neurodevelopmental Disorders and Neurotoxicology and Teratology.
Dr. Peterson is Professor and Director of the Human Nutrition Program in the Department of Environmental Health Sciences in the University of Michigan School of Public Health and Research, and Professor, Human Growth and Development at the University of Michigan (UMSPH). Trained as a nutritionist, her research focuses on the influence of adverse exposures on child growth and maturation during sensitive developmental periods and the potential mediating influence of dietary quality and lifestyle behaviors on exposure-outcome associations in multi-ethnic, low-income populations in the United States and Latin America. She has conducted extensive research on the epidemiology and evaluation of population-based interventions addressing child obesity. Dr. Peterson is the Principal Investigator of the EPA/NIEHS Formative Children’s Environmental Health and Disease Prevention Research Center at UMSPH, focused on “Perinatal exposures, epigenetics, child obesity & sexual maturation,” serves as Associate Director of the University of Michigan Nutrition and Obesity Research Center, and directs the Nutrition Assessment Laboratory of the Exposure Core of the UM Environmental Health Science Core Center, with research on “Lifestage exposures and adult disease.”
Dr. Rauh is Professor of Population and Family Health at the Mailman School of Public Health, Columbia University, and Deputy Director of the Columbia Center for Children's Environmental Health. Her work focuses on the adverse impact of exposure to air pollutants, including second hand smoke and pesticides on pregnancy and child health, and the susceptibility of disadvantaged populations to environmental hazards. Dr. Rauh is a perinatal epidemiologist, whose expertise is in the area of low birth weight and preterm delivery, particularly with respect to socioeconomically disadvantaged and minority populations. She has been principal investigator on numerous major research projects, including studies of the impact of organophosphorus insecticides and secondhand smoke on child neurodevelopment and structural brain abnormalities (MRI), a randomized intervention trial for low birth weight infants, a multi-site study of lifestyles in pregnancy, a study of developmental outcomes of children born to inner-city adolescent mothers, a multi-level analysis of the impact of Head Start on New York City school children, a study of the effects of ambient air pollutants on pregnant women and their children, and a study of links between race, stressors, and preterm birth. She has worked with other Columbia faculty to study the effects of the World Trade Center disaster on pregnant women and newborns. Dr. Rauh is currently principal investigator for the Manhattan Site and co-investigator for the Queens Vanguard Site of the National Children’s Study. Dr. Rauh serves on numerous national committees, including advisory groups at NIEHS, NICHD, and the Scientific Advisory Board for the Environmental Protection Agency.
Dr. Susan Schantz is a Professor of Environmental Toxicology in the Department of Comparative Biosciences at the University of Illinois in Urbana-Champaign. She has chaired the Interdisciplinary Environmental Toxicology Program since 1996, and she directs an Environmental Toxicology Training Grant funded by NIEHS and a Formative Children’s Environmental Health Research Center funded jointly by NIEHS and the USEPA. She is associate director of a Botanical Research Center funded by NCCAM, ODS and NCI. Her research focuses on understanding the nervous system effects of several widespread environmental contaminants including PCBs, PBDEs, phthalates and bisphenol A, and includes epidemiological studies of exposed human populations as well as laboratory studies in animal models. Recently, with funding from NIA and NCCAM, she has initiated another line of research investigating the impact of estrogens including soy isoflavones and other botanical estrogens on cognitive function during aging.
Dr. Szefler is the Helen Wohlberg and Herman Lambert Chair in Pharmacokinetics at National Jewish Health in Denver, Colorado. He is the Professor of Pediatrics and Pharmacology at the University of Colorado School of Medicine. Dr. Szefler's major contributions are directed toward the appropriate use of long-term control therapy in asthma. He is the Co-Director for the NIEHS/EPA Childhood Environmental Health Center Grant at National Jewish Health in Denver, Colorado.
Todd has a Bachelor’s degree in Civil Engineering from the University of Virginia and a Master’s degree in Environmental Engineering from the University of North Carolina-Chapel Hill. In the spring of 2011 he received his PhD. in Environmental Health Sciences from the UC Berkeley School of Public Health. Currently, Todd is a post-doctoral fellow at UC Berkeley and he is involved in the identification of environmental risk factors for childhood leukemia, as part of the Center for Integrative Research on Childhood Leukemia and the Environment. Todd is an exposure scientist and his focus is in evaluating the utility of measurement techniques for characterizing chemical exposures in human health studies. His PhD. dissertation dealt with estimating environmental exposures to indoor contaminants using residential-dust samples.
Dr. Joseph Wiemels is a professor of epidemiology at University of California, San Francisco. After completing his undergraduate degree in biology at Kenyon College, Ohio, he served in the Peace Corps teaching science subjects in the South Pacific. Dr. Wiemels received a Ph.D. in Environmental Health Sciences/Toxicology at the University of California, Berkeley, with minors in epidemiology and nucleic acid chemistry, in 1997. Dr. Wiemels joined a large pediatric leukemia epidemiology study as a postdoc in London, UK, before returning to California and taking up a position at UCSF in 2000.
Dr. Wiemels is committed to studying the epidemiology of childhood cancers with a focus on biology and natural history of the diseases. He has worked on tracing back the genetic and epigenetic origins of cancer, particularly childhood leukemia, and exploring the relationship of the host immune system and cancer in an epidemiologic fashion. His goal is to understand the biological mediators between genetic and environmental risk factors and disease, and how the immune system can detect and interact with cancers. Current projects include a genome wide association study of childhood leukemia and proposed GWAS in pediatric glioma, a large scale environmental risk factor and neonatal DNA methylation study, investigations into the role of autoantibodies in brain and other cancers, and the mechanisms behind allergies and Varicella virus-associations in brain cancers. Continued progress on all fronts will only be made through a combination of the best biology and epidemiology, and the shared worldwide resources and collaboration between investigators with disparate fields of interest.
Dr. Woodruff is Associate Professor and the Director of the Program on Reproductive Health and the Environment at University of California - San Francisco (UCSF). Her research interests are to advance scientific inquiry, professional training, public education and health policies that reduce the impacts of environmental contaminants on reproductive and developmental health.