Jump to main content or area navigation.

Contact Us

Extramural Research

Event

Title: Informational Webinar on: Organotypic Culture Models for Predictive Toxicology Centers RFA
Date: November 14, 2013
Location: Webinar
1:00 - 2:00 pm
Purpose:

Discuss the application process and required elements for the Organotypic Culture Models (OCM) for Predictive Toxicology Centers RFA. EPA is seeking research that may lead to 3D cell culture toxicity testing systems that include characterization of the molecular and cellular pathways perturbed by environmental chemicals.

Research areas for this solicitation include:

  • OCMs that recapitulate specific aspects of normal physiology, able to characterize the molecular and cellular pathways perturbed by environmental chemicals.
  • Adverse Outcome Pathways-based models that allow for quantitative measurement of linkages between molecular initiating events and relevant adverse outcomes, including key events that require the dynamics of a 3D culture.
  • Approaches and techniques to characterize the dosimetry of a chemical substance, including nanomaterials, as they relate to biologic pathway perturbation, both as a function of stressor severity (e.g., dose) and duration or timing of the perturbation.
  • OCMs amenable to medium or high throughput screening assays.

Learning objectives include:

  • Reviewing major research elements of the RFA
  • Reviewing administrative, electronic filing, eligibility, and peer review concerns
  • Answering attendee questions and FAQs
Contact:

Whitney Beck (Beck.Whitney@epa.gov); 703-347-0304

Registration: Register Now
Additional Info: View Solicitation
Webinar Flyer (PDF) (2 pp, 415 K)
Webinar Presentation (PDF) (27 pp,450 K)

Top of page

Jump to main content.