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Agenda: Workshop on Pharmaceuticals in the Environment

U.S. EPA National Exposure Research Laboratory
944 East Harmon Ave.
Las Vegas, NV 89119
August 23-25, 2005


OVERALL GOALS FOR THE WORKSHOP:

  • Provide an opportunity for STAR grantees to present the results of their research. (Summaries of the grantees projects can be accessed at:
    http://www.epa.gov/ppcp/ )
  • Identify research “gaps” important to addressing decisions and/or policy making issues associated with pharmaceuticals in the environment.
  • Provide an opportunity for information sharing among scientists and policy-makers from EPA’s program offices, regions, and the Office of Research and Development, as well as from States, local agencies, research entities and stakeholders, about the state-of-the science regarding the presence, fate, and effects of pharmaceuticals in the environment and techniques and tools for Regions’ and/or States’ monitoring programs.
  • To the extent there is a problem, identify ways that EPA can be part of the solution by improving the understanding of “institutional barriers” and discussing programmatic approaches (headquarters and Regions)
  • Explore the use of voluntary, collaborative approaches to reducing pharmaceuticals in the environment that include Regions and Program Offices, States, Tribes, other federal agencies, and stakeholders
You will need Adobe Acrobat Reader, available as a free download, to view some of the files on this page. See EPA's PDF page to learn more about PDF, and for a link to the free Acrobat Reader.
Tuesday, August 23, 2005
INTRODUCTION & OVERVIEW
8:00 – 9:45 a.m. Moderator: Angela Page, EPA, Office of Research and Development
7:30 – 8:00 a.m. Registration
8:00 - 8:15 a.m.

Welcome
Christian Daughton , U.S. EPA, Office of Research and Development [Presentation (PDF, 7pp., 592KB)] [No abstract submitted]

8:15 - 8:30 a.m.

Overview of the U.S. EPA's Office of Research and Development and the Science to Achieve Results (STAR) Program
Angela D. Page , U.S. EPA, Office of Research and Development [Presentation (PDF, 18pp., 805KB)] [No abstract submitted]

8:30 - 8:50 a.m.

Overview Presentation from the U.S. EPA's Office of Water
Octavia Conerly, U.S. EPA, Office of Water [Presentation (PDF, 16pp., 113KB)] [No abstract submitted]

8:50 - 9:15 a.m.

The EPA Regional Perspective – Why Pharmaceuticals in the Environment are an Emerging Science Issue to EPA ’s Regions
Bobbye Smith , U.S. EPA Region 9, National Regional Science Council [Presentation (PDF, 14pp., 217KB)] [No abstract submitted]

9:15 – 9:45 a.m.

Overview of Science Involved with Pharmaceuticals: a Perspective from the U.S. EPA
Christian Daughton , U.S. EPA, Office of Research and Development [Presentation (PDF, 59pp., 2.75MB)] [No abstract submitted]

9:45 – 10:05 a.m. BREAK
FATE, EFFECTS AND OCCURRENCE OF PHARMACEUTICALS IN THE ENVIRONMENT - Session A
10:05 – 11:55 a.m. Moderator: Angela Page, U.S. EPA, Office of Research and Development
10:05 – 10:30 a.m.

Occurrence, Environmental Fate and Exposure Assessment of Selective Serotonin Reuptake Inhibitors (SSRIs) in Aquatic Environments
Presented by Kevin Armbrust, Office of the State Chemist, Mississippi State Chemical Laboratory of Mississippi, Mississippi State, MS (STAR Grant) [Presentation (PDF, 28pp., 721KB)], Abstract

10:30 – 10:55 a.m.

Occurrence and Fate of Antibiotics and other Pharmaceutically Active Compounds during Transport to and through During Drinking Water Treatment
Presented by Howard Weinberg, University of North Carolina, NC (STAR Grant), [Presentation not available], Abstract

10:55 – 11:20 a.m.

Occurrence and Fate of High Volume Pharmaceuticals in Wastewater Impacted Environments
Grant Recipient: Bruce Brownawell, Presented by Mark Benotti, State University of New York at Stony Brook, NY (STAR Grant) [Presentation, (PDF, 24pp., 1.02MB)], Abstract

11:20 - 11:45 a.m.

Detection and Fate of Environmental Estrogens in Wastewater Impacted Surface and Groundwaters
Presented by Bruce Brownawell, State University of New York at Stony Brook, NY (STAR Grant), [Presentation not available], Abstract

11:45 – 1:30 p.m. LUNCH
FATE, EFFECTS AND OCCURRENCE OF PHARMACEUTICALS IN THE ENVIRONMENT – Session B
1:30 – 4:20 p.m. Moderator: Cynthia Nolt-Helms, U.S. EPA, Office of Research and Development
1:30 – 1:55 p.m.

Mechanisms of tetracycline resistance development in the environment as detected by real-time PCR
Presented by David Graham, University of Kansas, Lawrence, KS (STAR Grant), [Presentation not available], Abstract

1:55 – 2:20 p.m.

Fate, attenutation, and effects of fluoroquinolone antibacterials in aquatic systems
Grant Recipient: David Graham, Presented by Charles Knapp, University of Kansas, Lawrence, KS (STAR Grant), [Presentation not available], Abstract

2:20 – 2:45 p.m.

Adsorption of beta-blocker anti-hypertensive pharmaceuticals to a range of mineral surfaces
Presented by Tohren Kibbey, University of Oklahoma, Norman, OK (STAR Grant), [Presentation not available], Abstract

2:45 – 3:10 p.m.

Pharmaceuticals and Personal Care Products as Environmental Contaminants: Biodegradability Studies and Occurrence in Sewage Treatment Plant Influent and Effluent
Grant Recipient: Lynn Roberts, Presented by Jim Yu, The Johns Hopkins University; Baltimore, MD (STAR Grant), [Presentation not available], Abstract

3:10 – 3:30 p.m. BREAK
3:30 – 3:55 p.m.

Pharmaceuticals and Personal Care Products as Environmental Contaminants: Preliminary
Environmental Risk Calculations and Method Development for Analysis in Environmental Media via
GC/MS
Grant Recipient: Lynn Roberts , Presented by Kevin Bisceglia, The Johns Hopkins University, Baltimore, MD (STAR Grant), [Presentation not available], Abstract

3:55 – 4:20 p.m.

Endocrine Effects of Selective Serotonin Reuptake Inhibitors (SSRIs) on Aquatic Organisms
Presented by Marsha Black, University of Georgia, Athens, GA (STAR Grant) [Presentation (PDF, 34pp., 1010KB)], Abstract

4:20 – 5:30 p.m.

Poster Session
Investigators will be available to discuss their posters highlighting research on pharmaceuticals in the environment.

5:30 p.m. Adjourn

Wednesday, August 24, 2005
HAZARDS FROM WASTE PHARMACUETICALS: DETERMINING TOXICITY AND CHEMICAL ANALYTICAL METHODS FOR DETECTION
8:00 – 11:50 a.m. Moderator: Tammy Jones-Lepp, U.S. EPA, Office of Research and Development
8:00 – 8:25 a.m.

Overview of a Framework for Assessing the Hazards of Human Pharmaceuticals in the Environment from a SETAC Pellston Workshop
Presented by Marsha Black , University of Georgia, Athens, GA [Presentation (PDF, 21pp., 146KB)], Abstract

8:25 - 8:50 a.m.

Overview of ORD’s Aquatic Toxicology Research on Endocrine-Active Pharmaceuticals
Presented by Joseph E. Tietge, U .S. EPA, Office of Research and Development, [Presentation not available], Abstract

8:50 – 9:15 a.m.

Analytical Methods for Measurement of Pharmaceuticals in Drinking Water and in the Environment
Presented by Mike Meyer, U.S. Geological Survey, [Presentation not available], [No abstract submitted]

9:15 – 9:40 a.m.

Environmental Risk Assessment of Pharmaceuticals in the Environment
Presented by Charles Eirkson, U.S. FDA, Center for Veterinary Medicine [Presentation (PDF, 32pp., 325KB)], [No abstract submitted]

9:40 – 10:05 a.m.

An Informatic Approach to Estimating Ecological Risks Posed by Pharmaceutical Use
Presented by Mitchell Kostich, U .S. EPA, Office of Research and Development [Presentation (PDF, 13pp., 356KB)], Abstract

10:05 – 10:25 a.m. BREAK
10:25 - 10:50 a.m.

Identifying Chemical Compounds from Wastewater Discharges
Presented by Susan Glassmeyer, U .S. EPA, Office of Research and Development [Presentation (PDF, 15pp., 645KB)], Abstract

10:50 -11:45 a.m. Research and Regional Needs Breakout Sessions

BREAKOUT SESSION I : What chemical methods are needed for Monitoring Pharmaceuticals in the Environment? What are the barriers in using existing chemical methods for Monitoring Pharmaceuticals in the Environment?

Moderators:
Session A: Al Alwan, U.S. EPA, Region 5 [Presentation (PDF, 4pp., 26KB)], [No abstract submitted]
Session B: Susan Glassmeyer U.S. EPA, ORD [Presentation (PDF, 2pp., 17KB)], [No abstract submitted]

Breakout Questions:

  • Can EPA process, for developing new chemical methods, be modified to address the new pharmaceuticals?
  • Should we evaluate other options, out side EPA, if so which?
  • What pharmaceuticals concentration would EPA use for base line and target monitoring?
  • Which pharmaceuticals should the Regions focus on monitoring?
  • What can we do until there are EPA approved methods for detection of pharmaceuticals and personal care products?
  • How to find out the relative mass of unused versus excreted drugs that enter into waste water treatment plants?

BREAKOUT SESSION II: What Environmental Exposure and Effects Methods are Needed for Ecologic Receptors?

Moderators:
Session A: Bobbye Smith, U.S. EPA, Region 9 [Presentation (PDF, 3pp., 25KB)], [No abstract submitted]
Session B: Djanette Khiari, AWWA Research Foundation [Presentation (PDF, 5pp., 27KB)], [No abstract submitted]

Breakout Questions:

  • What new bioassays can the Regions and Programs use with existing resources?
  • What pharmaceuticals should the Regions focus monitoring resources on?
  • What EPA bioassay methods can be used?
  • Are there other agency or stakeholder-sponsored assessment methods that would be useful?
  • What are the method gaps?
11:45 - 1:00 p.m. LUNCH
ENVIRONMENTAL STEWARDSHIP FOR PHARMACEUTICALS IN THE ENVIRONMENT – Session A
1:00 – 5:00 p.m. Moderator: Octavia Conerly, U.S. EPA, Office of Water
1:00 – 1:25 p.m.

Research needs and gaps from the perspective of the major water societies
Presented by Djanette Khiari, AWWA Research Foundation [Presentation (PDF, 28pp., 278KB)], [No abstract submitted]

1:25 – 1:50 p.m.

Perspectives from Drinking Water Suppliers
Presented by J.C. Davis, Southern Nevada Water Authority [Presentation (PDF, 19pp., 658KB)], Abstract

1:50 - 2:15 p.m.

Wastewater Treatment Plant Perspectives: Preliminary Data Suggesting Endocrine Disruptor Effects of Wastewater Discharge into the Pacific Ocean
Presented by Jeffrey Armstrong, Orange County California Sanitation District [Presentation (PDF, 19pp., 832KB)], Abstract

2:15 – 2:35 p.m. BREAK
2:35 - 3:00 p.m.

Perspectives from the Drug Enforcement Agency on what can and cannot be done via drug take-back programs
Presented by Vickie Seeger, U.S. DEA, Office of Diversion Control [Presentation (PDF, 10pp., 241KB)], Abstract

3:00 – 3:25 p.m.

Perspectives from the Pharmaceutical Industry
Presented by Mary Buzby, Merck & Co., Inc., representing the Pharmaceutical Research and Manufacturers of America [PhRMA] PIE Task Force [Presentation (PDF, 32pp., 613KB)], Abstract

3:25 – 3:50 p.m.

Environmental Stewardship of Waste Pharmaceuticals from a Hospital Perspective
Presented by Charlotte Smith, PHARMECOLOGY [Presentation (PDF, 61pp., 1.67MB)], Abstract

3:50 – 4:10 p.m. Report-Outs from Mornings Break-Out Sessions
4:15 – 5:30 p.m. Breakout Sessions on Identifying the Barriers

What Are the Barriers to Reducing Pharmaceuticals in the Environment?
(Panel of Rapporteurs from Days 1 & 2 day synthesize the “learnings”)

BREAKOUT SESSION I: What are the Barriers to Using Existing Bioassay Tools to Assess Exposure and Effects of Pharmaceuticals in the Environment?

Moderators: Bobbye Smith , U.S. EPA, Region 9 [Presentation (PDF, 7pp., 34KB)], [No abstract submitted]

  • What can we do until there are EPA approved methods for detection of pharmaceuticals and personal care products?

BREAKOUT SESSION II: What are the Programmatic and/or Regulatory Constraints to Reducing Pharmaceuticals in the Environment?

Moderator: Jan Baxter, U.S. EPA, Region 9

Session II
Policy [Presentation (PDF, 5pp., 29KB)], [No abstract submitted]

Moderator: Chen Wen, U.S. EPA, Office of Pollution Prevention and Toxics

Session IIA
The Programmatic and/or Regulatory Constraints to Reducing Pharmaceuticals in the Environment [Presentation (PDF, 4pp., 25KB)], [No abstract submitted]

[Pharmaceutical Waste Disposal Flow Chart Graphic discussed in group]
  • Where in the "lifecycle" of drugs are there opportunities for waste diversion and pollution prevention?
  • How would the participants rank the various opportunities in terms of possibility for greatest impact? Ease of implementation?
  • Of the identified opportunities, are there regulatory and institutional barriers that currently exist? If so, what are they?
  • What other stakeholders (Federal agencies, states, private sector) should engage in this coversation?
5:30 p.m. Adjourn

Thursday, August 25, 2005
ENVIRONMENTAL STEWARDSHIP FOR PHARMACEUTICALS IN THE ENVIRONMENT – Session B
8:00 – 11:45 a.m. Moderator: Mary Dever, U.S. EPA, Region 1
8:00 – 8:25 a.m.

Managing Emerging Contaminants: A Practical Approach
Presented by Al Alwan, U.S. EPA, Region 5 [Presentation (PDF, 23pp., 96KB)], Abstract

8:25 – 8:50 a.m.

The Metropolitan Water Reclamation District of Greater Chicago’s Efforts to Reduce Pharmaceuticals that enter the Water Reclamation Plants
Presented by Catherine O'Connor, Metropolitan Water Reclamation District of Greater Chicago [Presentation (PDF, 15pp., 440KB)], Abstract

8:50 – 9:15 a.m.

Collecting Unwanted Medications for Appropriate Disposal
Presented by Lynn Rubinstein, Northeast Recycling Council [Presentation (PDF, 23pp., 326KB)], Abstract

9:15 – 9:40 a.m.

Maine: First US Legislation for Unused Pharmaceutical Returns
Presented by Stevan Gressitt, Maine Association of Psychiatric Physicians, Medical Director of Northeast Occupational Exchange, Acting Secretary of the Maine Benzodiazepine Study Group,[Presentation (PDF, 36pp., 1.19MB)], Abstract

9:40 – 10:05 a.m.

Washington State and King County’s Perspective on Pharmaceutical Stewardship
Presented by David Galvin, King County Washington [Presentation (PDF, 20pp., 1015KB)], Abstract

10:05 – 10:20 a.m. Report-Outs from Wednesday afternoon Break-Out Sessions
10:20 – 11:30 a.m.

Facilitated Discussion: What are the Next Steps to Address the Issue of Pharmaceuticals in the Environment? How can EPA be Part of the Solution?

Moderator: To Be Determined (Multi-Media Pollution Prevention Office and/or Office of Waste Water Management?)
Facilitator: Bobbye Smith, U.S. EPA, Region 9

Panel of stakeholders, researchers, agencies initiate discussion with audience.

Initial Discussion Questions:

  • What can we do until there are EPA approved methods for detection of pharmaceuticals and personal care products?
  • What are the key agencies and stakeholders to include in pollution prevention discussions?
  • What internal EPA vetting needs to be done to develop a champion?
  • Are there existing “solutions” that could be piloted in other states, business sectors?
  • Are there cleanup and/or destruction (management) options that could be developed in cooperation with industry sectors?
  • What are the “tools” or approaches? Is there an “energy star”-like opportunity?
  • Product stewardship – how can those principals be made into business opportunities?
  • How to “green” the supply chain and/or reduce the waste stream volume?
  • How to engage with individuals to influence behavior (e.g., don’t flush drugs)?
  • How to address “distributed” health care, e.g., nursing homes, hospice, drug rehabilitation centers?
  • How to find out the relative mass of unused versus excreted drugs that enter into waste water treatment plants?
  • What will Regions, States, and Tribes do to monitor for pharmaceuticals?
  • Who will be the HQ and/or Regional “champions” to work for solutions?
11:30-11:45 a.m. Wrap-Up and Next Steps
11:45 a.m. Adjourn

 

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