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Extramural Research

2006 Level III Scientific And Technological Achievement Awards (STAA)

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Extramural Research Search

Level III awards - are for those who have accomplished an unusually notable research or technological effort. The awards are for a substantial revision or modification of a scientific/technological principle or procedure, or an important improvement to the value of a device, activity, program, or service to the public. Awarded research relates to a mission or organizational component of the EPA, or significantly affects a relevant area of science/technology.

Scientist at work  Bumblebee  ORD Research Vessel  Field sampling

Nominations Recommended for a Level III Award ($1000) -- Total of Twenty-Nine
Nom. # Titles and Citations of Submitted Papers Eligible Authors* and Nominating Organizations Ineligible Authors and Organization Citation
S6CS0004 a) Repeated Reductive and Oxidative Treatments of Granular Activated Carbon. Journal of Environmental Engineering, 131(2):288-297 (2005)
b) Fenton-Driven Chemical Regeneration of MTBE-Spent GAC. Water Research, 39:2145-2153 (2005)
Scott G. Huling (65%)
P. Kyle Jones (25%)

Robert G. Arnold (5%) -- University of Arizona
Wendell P. Ela (5%) -- University of Arizona
Process Fundamentals and Development of the Adsorption/Oxidation Treatment Process
S6CS0005 a) High Temperature Interaction between Residual Oil Ash and Dispersed Kaolinite Powders. Aerosol Science & Technology, 38:900-913 (2004)
b) High-Temperature Sorption of Cesium and Strontium on Dispersed Kaolinite Powders. Environmental Science & Technology, 39(13):5087-5094 (2005)
William P. Linak (40%)
C. Andrew Miller (10%)
Joseph P. Wood (10%)

NRMRL, Research Triangle Park, NC
Jong-Ik Yoo (15%) --Oak Ridge Institute for Science and Education, TN
Dawn A. Santoianni (8%) -- ARCADIS G&M Inc., NC
Charles J. King (5%) -- ARCADIS G&M, Inc., NC
Takuya Shinagawa (5%) -- JFE Engineering Corp., Japan
Jost O.L. Wendt (5%) -- University of Tucson, AZ
Yong-Chil Seo (2%) -- University of Yonsei, Korea
Developing New Approaches to Toxic Metal Emissions Control From High Temperature Industrial Processes

1H-NMR-Based Metabonomics Analysis of Sera Differentiates between Mammary Tumor-Bearing Mice and Healthy Controls. Metabolomics, 1(4):online fir (2005)

Applications of In Vitro NMR Spectroscopy and 1H-NMR Metabonomics to Breast Characterization and Detection. Progress in Nuclear Magnetic Resonance Spectroscopy, 47(3-4):165-174 (2005)
Tracy L. Whitehead (90%)

NERL, Athens, GA

Tracy L. Whitehead (90%)

NERL, Athens, GA
Thomas Kieber-Emmons (10%) -- University of Arkansas for Medical Sciences

Thomas Kieber-Emmons (5%) --
University of Arkansas for Medical Sciences
Behjatolah Monzavi-Karbassi (5%) --
University of Arkansas for Medical Sciences

Demonstrating the Applicability of NMR Metabolomics in the Study of Carcinogenesis
S6EF0075 Scenario Analysis for the San Pedro River, Analyzing Hydrological consequences of a Future Environment. Environmental Monitoring and Assessment, 94:115-127 (2004) William G. Kepner (45%)
Darius J. Semmens (45%)

NERL, Las Vegas, NV
David C. Goodrich (4%) -- U.S. Department of Agriculture, AZ
Scott D. Bassett (3%) -- Desert Research Institute, NV
David A. Mouat (3%) -- Desert Research Institute, NV
Developing a Methodology to Evaluate Landscape Change and Determine Environmental Vulnerability
S6ER0009 Relationships of Nitrogen Loadings, Residential Development, and Physical Characteristics with Plant Structure in New England Salt Marshes. Estuaries, 26(6):1494-1504 (2003) Cathleen Wigand (40%)
Richard A. McKinney (35%)
Marnita M. Chintala (10%)
Glen B. Thursby (5%)

NHEERL, Narragansett, RI
Michael A. Charpentier (10%) -- CSC Corporation, RI Outstanding Research Supporting the Ecological Assessment of the Condition of Coastal Wetlands
S6ER0010 a) Projected Population-Level Effects of Thiobencarb Exposure on the Mysid, Americamysis Bahia, and Extinction Probability in a Concentration-Decay Exposure System. Environmental Toxicology and Chemistry (SETAC), 24(3):564-572 (2005)
b) Projecting Population-Level Responses of Mysids Exposed to Endocrine Disrupting Chemical. Integrative and Comparative Biology, 45:151-157 (2005)
c) The Influence of Insect Juvenile Hormone Agonists on Metamorphosis and Reproduction in Estuarine Crustaceans. Integrative and Comparative Biology, 45(1):97-105 (2005)
Sandy Raimondo (60%)
Charles L. McKenney, Jr. (40%)

NHEERL, Gulf Breeze, FL
  Advancing the State of Science Regarding Population-Level Environmental Risk Assessments
S6ER0012 a) Denitrification Enzyme Activity of Fringe Salt Marshes in New England. Journal of Environmental Quality, 33:1144-1151 (2004)
b) Response of Spartina patens to Dissolved Inorganic Nutrient Additions in the Field. Journal of Coastal Research, (45):134-149 (2004)
Cathleen Wigand (50%)
Richard McKinney (30%)
Glen B. Thursby (10%)
Marnita Chintala (3%)
Antelmo Santos (2%)

NHEERL, Narragansett, RI
Peter Groffman (3%) -- Institute of Ecosystem Studies, NY
Michael Charpentier (2%) -- CSC Corporation, RI
A Significant Contribution to Research on the Effects of Nitrogen Enrichment on Coastal Wetland Functions
S6ES0076 Development of a Ct Equation Taking Into Consideration the Effect of Lot Variability on the Inactivation of Cryptosporidium Parvum Oocysts With Ozone. Water Research, 39(11):2429-2437 (2005) Mano Sivaganesan (80%)

NRMRL, Cincinnati, OH
Benito Marinas (20%) -- University of Illinois at Urbana-Champaign Recognition of this Outstanding Research Intended to Protect the Public Health of Drinking Water Consumers
S6ES0079 On-Road Testing and Characterization of Fuel Economy of Light-Duty Vehicles. Society of Automotive Engineers (SAE) Technical Paper Series, (2005-01-0677):1-10 (2005) Richard A. Rykowski (45%)
Edward Nam (40%)

OTAQ, Ann Arbor, MI
George Hoffman (15%) -- Computer Sciences Corporation, MI Exceptional Technical Achievement in the Development of a New Methodology for Quantifying Real-World Fuel Economy


a) Neurochemical Effects of Chronic Dietary and Repeated High-Level Acute Exposure to Chlorpyrifos in Rats. Toxicological Sciences, 88(1):161-171 (2005)
b) Repeated Spike Exposure to the Insecticide Chlorpyrifos Interferes with the Recovery of Sensitivity in Rats. Ophthalmologica, 110:79-90 (2005)

The Effects of Chlorpyrifos on Blood Pressure and Temperature Regulation in Spontaneously Hypertensive Rats. Basic & Clinical Pharmacology and Toxicology, 96:503-511 (2005)

a) Neurobehavioral Effects of Chronic Dietary and Repeated High-Level Spike Exposure to Chlorpyrifos in Rats. Toxicological Sciences, 86(2):375-386 (2005)
b) Effects of Chronic Dietary and Repeated Acute Exposure to Chlorpyrifos on Learning and Sustained Attention in Rats. Toxicological Sciences, 87(2):460-468 (2005)
Andrew M. Geller (15%)
Deborah L. Hunter (15%
Renee S. Marshall (15%)
Stephanie Padilla (15%)
Laura D. Sutton (15%)
Virginia C. Moser (3%))

Christopher J. Gordon (50%)

NHEERL, Research Triangle Park, NC

Tracey Samsam (30%)
Virginia (Ginger) Moser (20%)
Philip J. Bushnell (10%)
Deborah Hunter (10%)
Renee Marshall (10%)
Pamela Phillips (10%)
Kathy McDaniel (5%)
Stephanie Padilla (5%)

NHEERL, Research Triangle Park, NC
Sharon Oxendine (6%) -- University of North Carolina at Chapel Hill
Victoria Madden (5%) -- University of North Carolina at Chapel Hill
Stanely B. Southerland (5%) -- University of North Carolina at Chapel Hill
Richard B. Mailman (3%) -- University of North Carolina at Chapel Hill
Robert L. Peiffer (3%) -- Merck Research Laboratories, PA

Edward G. Smith (50%) -- Livingstone College, NC

Experimental Analysis of the Chronic Biochemical and Retinal Neurotoxicity of an Organophosphorus Pesticide

Hypertension Increases Sensitivity to an Organophosphate Insecticide

Experimental Analysis of the Chronic Behavioral Neurotoxicity of an Organophosphate Pesticide
S6HE0022 a) Total Lung Deposition of Ultrafine Particles in Elderly Subjects During Controlled Breathing. Inhalation Toxicology, 17(8):387-399 (2005)
b) Analysis of Total Respiratory Deposition of Inhaled Ultrafine Particles in Adult Subjects at Various Breathing Patterns. Aerosol Science & Technology, 38(6):525-540 (2004)
Chong S. Kim (60%)

NHEERL,  Research Triangle Park, NC
Peter A. Jaques (40%) -- Clarkson University, NY Comparative Ultrafine Particle Dosimetry Studies for Young and Elderly Subjects
S6HE0024 a) Transcriptomic Analysis of F344 Rat Nasal Epithelium Suggests that the Lack of Carcinogenic Response to Glutaraldehyde is Due to its Greater Toxicity Compared to Formaldehyde. Toxicologic Pathology, 33(4):415-424 (2005)
b) Formaldehyde-Induced Gene Expression in F344 Rat Nasal Respiratory Epithelium. Toxicology, 187(1):13-24 (2003)
Susan D. Hester (40%)
Douglas C. Wolf (35%)

NHEERL,  Research Triangle Park, NC
William Barry (8%) -- University of North Carolina, Chapel Hill
Fei Zou (8%) -- University of North Carolina, Chapel Hill
Gina B. Benavides (3%) -- GlaxoSmithKline, Inc., NC
Kevin T. Morgan (3%) -- GlaxoSmithKline, Inc., NC
Lawrence Yoon (3%) -- GlaxoSmithKline, Inc., NC
The Use of Transcriptional Profiling to Determine Carcinogenicity of Air Toxics
S6HE0025 a) Neurotoxicological and Statistical Analyses of a Mixture of Five Organophosphorus Pesticides using a Ray Design. Toxicological Sciences, 86(1):101-115 (2005)
b) Thermoregulatory Response to a Organophosphate and Carbamate Insecticide Mixture: Testing the Assumption of Dose-Additivity. Toxicology, 217(1):1-13 (2006)
c) D-Optimal Experimental Designs to Test for Departure from Additivity in a Fixed-Ratio Mixture Ray. Toxicological Sciences, 88(2):467-476 (2005)
Christopher J. Gordon (18%)
Jaime E. Graff (18%)
David W. Herr (18%)
Cina M. Mack (18%)
Virginia C. Moser (18%)
Jane Ellen Simmons (10%)

NHEERL, Research Triangle Park, NC
  Development of Methods and Data to Assess Dose-Additivity for Mixtures of Cholinesterase-Inhibiting Pesticides
S6HE0027 a) Accumulation and Metabolism of Arsenic in Mice After Repeated Oral Administration of Arsenate in Mice. Toxicology and Applied Toxicology, 191:202-210 (2003)
b) Tissue Distribution and Urinary Excretion of Inorganic Arsenic and its Methylated Metabolites in Mice Following Acute Oral Administration of Arsenate. Toxicological Sciences, 85:468-475 (2005)
c) An Integrated Pharmacokinetic and Pharmacodynamic Study of Arsenite Action 2. Heme Oxygenase Induction in Mice. Toxicology, 206:389-401 (2005)
Michael F. Hughes (20%)
Elaina M. Kenyon (20%)
Brenda Edwards (15%)
Carol T. Mitchell (15%)
Kirk T. Kitchin (5%)
David J. Thomas (5%)

NHEERL, Research Triangle Park, NC
Luz Maria Del Razo (20%) -- CINVESTAV IPN, Mexico Development of Data for PBPK Modeling on the In Vivo Fate of Inorganic Arsenic
S6HE0029 a) Mechanisms of Zn2+-Induced Signal Initiation through the Epidermal Growth Factor Receptor. Toxicology and Applied Pharmacology, 191(1):86-93 (2003)
b) Zn2+Induced IL-8 Expression InvolvesAP-1, JNK and P38 Activities in Human Airway Epithelial Cells. American Journal of Physiology: Lung Molecular and Cellular Physiology, : (2005)
c) Inhibition of Protein Tyrosine Phosphates Activity Mediates Epidermal Growth Factor Receptor Signaling in Human Airway Epithelial Cells Exposed to Zn2+. Toxicology and Applied Pharmacology, : (2005)
James M. Samet (50%)
Robert Silbajoris (10%)

NHEERL, Research Triangle Park, NC
YuMee Kim (17%) -- University of North Carolina,  Chapel Hill
Tamara Tal (17%) -- University of North Carolina, Chapel Hill
Brian Dewar (2%) -- University of North Carolina,  Chapel Hill
Lee M. Graves (2%) -- University of North Carolina, Chapel Hill
Philip Bromberg (1%) -- University of North Carolina, Chapel Hill
Weidong Wu (1%) -- University of North Carolina,  Chapel Hill
Elucidation of the Molecular Mechanism of Toxicity of Zinc in Human Lung Cells
S6HE0082 a) In Vivo and In Vitro Anti-Androgenic Effects of DE-71, a Commercial Polybrominated Diphenyl Ether (PBDE) Mixture. Toxicology and Applied Pharmacology, 207(1):78-88 (2005)
b) Assessment of DE-71, a Commercial Polybrominated Diphenol Ether (PBDE) Mixture, in the EDSP Male and Female Pubertal Protocols. Toxicological Sciences, 78:144-155 (2004)
Tammy E. Stoker (25%)
Ralph L. Cooper (15%)
Christy Lambright (11%)
Kevin M. Crofton (10%)
L. Earl Gray (10%)
Susan Laws (10%)
Vickie Wilson (10%)
Janet Ferrell (3%
Jonathan Furr (3%)
Joan Hedge (3%)

NHEERL, Research Triangle Park, NC
  The Effects of the Flame Retardant Mixture, DE-71, on Thyroid Homeostasis and Demonstration of Anti-Androgenic Activity
S6IR0070 Investigating Uncertainty and Sensitivity in Integrated Multimedia Environmental Models: Tools for FRAMES-3MRA. Environmental Modelling and Software, 20(8):1043-1055 (2005) Justin E. Babendreier (90%)

NERL, Athens, GA
Karl J. Castleton (10%) --
Pacific Northwest National Laboratory, Battelle, CO
Pioneering Development of Hardware and Supporting Software Systems for the Evaluation of Complex, Integrated Models
S6MM0035 Air Levels of Carcinogenic Polycyclic Aromatic Hydrocarbons After the World Trade Center Disaster. Proceedings of the National Academy of Sciences, 101(32):11685-688 (2004) Joachim D. Pleil (70%)
Alan F. Vette (15%)

NERL, Research Triangle Park, NC
Stephen M. Rappaport (10%) --
University of North Carolina at Chapel Hill
Brent A. Johnson (5%) --
University of North Carolina at Chapel Hill
Innovative Research and Measurements of Airborne Carcinogenic Risk After the World Trade Center Disaster
S6MM0080 Polar Organic Chemical Integrative Sampling and Liquid Chromatography-Electrospray/Ion-Trap Mass Spectrometry for Assessing Selected Prescription and Illicit Drugs in Treated Sewage Effluents. Archives of Environmental Contamination and Toxicology, 47(4):427-439 (2004) Tammy L. Jones-Lepp (70%)

NERL, Las Vegas, NV
David A. Alvarez (20%) -- Columbia Environmental Research Center, MO
Jim N. Huckins (5%) -- Columbia Environmental Research Center, MO
Jim D. Petty (5%) -- Columbia Environmental Research Center, MO
Development and Application of New Methodologies for Discovering Emerging Contaminants in the Nation's Water Supply

Relationship of Stream Flow Regime in the Western Lake Superior Basin to Watershed Type Characteristics. Journal of Hydrology, 309:258-276 (2005)

a) Watershed-based Survey Designs. Environmental Monitoring and Assessment, 103:59-81 (2005)
b) How Probability Survey Data Can Help Integrate 305(b) and 303(d) Monitoring and Assessment of State Waters. Environmental Monitoring and Assessment, 103:41-57 (2005)
Sharon Batterman (20%)
Naomi Detenbeck (20%)
Virginia Snarski (20%)
Debra Taylor (20%)

Barbara Brown (25%)
Naomi Detenbeck (25%)
Anthony R. Olsen (10%)
Ann M. Pitchford (10%)

NHEERL, Duluth, MN
Valerie Brady (20%) -- Natural Resources Research Institute, MN

Judith M. Denver (10%) -- U.S. Geological Survey, DE
Susan K. Greenlee (10%) -- U.S. Geological Survey, SD
Dan Cincotta (5%) -- West Virginia Dept. of Natural Resources
Richard Eskin (5%) -- Maryland Department of Environment
Characterization of Hydrology Regimes by Watershed Type

Survey Designs Supporting Integrated Reporting of Condition and Listing of Impaired Water Bodies
S6RA0055 Review of Evidence: Are Endocrine-Disrupting Chemicals in the Aquatic Environment Impacting Fish Populations? Science of the Total Environment, 343:1-34 (2005) Lesley J. Mills (90%)

NHEERL, Narragansett, RI
Clinton O. Chichester (10%) -- University of Rhode Island A Significant Contribution to Research on the Effects of Endocrine-Disrupting Chemicals in the Aquatic Environment
S6RA0059 a) Scientific Authorship, Part 1: A Window into Scientific Fraud? Mutation Research, 589(1):17-30 (2005)
b) Scientific Authorship, Part 2: History, Recurring Issues, Practices and Guidelines. Mutation Research, 589(1):31-45 (2005)
Larry D. Claxton (100%)

NHEERL, Research Triangle Park, NC
  Providing a Comprehensive, Scholarly Review of Scientific Authorship Issues
S6RA0086 Genotoxicity of Tobacco Smoke and Tobacco Smoke Condensate: A Review. Mutation Research, 567(2-3):447-474 (2004) David M. DeMarini (100%)

NHEERL, Research Triangle Park, NC
  Review of the Genotoxicity of Tobacco Smoke
S6RA0091 Application of Frog Embryo Teratogenesis Assay-Xenopus to Ecological Risk Assessment. Environmental Toxicology and Chemistry, 24(10):2677-2690 (2005) Gerald Ankley (50%)

NHEERL, Duluth, MN
Robert Hoke (50%) -- DuPont, DE Review of Application of FETAX to Ecological Risk Assessments
S6RM0064 Predicting Sustainable Ground Water to Constructed Riparian Wetlands: Shaker Tracee, Ohio, USA. The Environmentalist, 24:179-186 (2004) William Sidle (100%)

NRMRL, Cincinnati, OH
  A New Method to Predict the Sustainability of Wetland Ponds for Successful Ecological Restoration
S6RM0065 a) Chromium-Removal Processes During Groundwater Remediation by a Zerovalent Iron Permeable Reactive Barrier. Environmental Science and Technology, 39(12):4599-4605 (2005)
b) High-Level Arsenite Removal from Groundwater by Zerovalent Iron. Chemosphere, 59(3):377-386 (2005)
Richard T. Wilkin (60%)
Robert G. Ford (5%)
Cynthia J. Paul (5%)
Chunming Su (5%)

Hsing-Lung Lien (25%) -- National University of Kaohsiung, China Providing a Scientific Foundation for Understanding Chromium and Arsenic Remediation Processes
S6TF0040 Quantitative Structure Property Relationships for Enhancing Predictions of Synthetic Organic Chemical Removal from Drinking Water by Granular Activated Carbon. Environmental Science & Technology, 39(19):7706-7711 (2005) Matthew L. Magnuson (50%)
Thomas F. Speth (50%)

NHSRC, Cincinnati, OH
  Developing a Valuable Modeling Tool for Evaluating Granular Activated Carbon Treatment of Specific Contaminants
S6TF0041 Modeling Mercury Fluxes and Concentrations in a Georgia Watershed Receiving Atmospheric Deposition Load from Direct and Indirect Sources. Journal of the Air & Waste Management Association, 55(5):547-558 (2005) Robert B. Ambrose, Jr. (50%)
Timothy A. Wool (30%)

NERL, Athens, GA
Ioannis X. Tsiros (20%) -- Agricultural University of Athens, Greece Developing and Demonstrating Watershed and Water Body Modeling Tools to Determine Allowable Hg Emissions
S6TF0043 Purification and Partial Characterization of an Acid Phosphatase from Spirodela Oligorrhiza and its Affinity for Selected Organophosphate Pesticides. Journal of Agricultural and Food Chemistry, 53:90-97 (2005) Christopher S. Mazur (80%)
Nelson L. Wolfe (10%)

NERL, Athens, GA
Christopher F. Hoehamer (10%) -- National Research Council

Developing an Enzyme Isolation Procedure from an Aquatic Plant Responsible for the Hydrolysis of OP Chemicals
Key to Acronyms used in the above Table
NCEA National Center for Environmental Assessment
NERL National Exposure Research Laboratory
NHEERL National Health and Environmental Effects Laboratory
NHSRC National Hazardous Substance Research Center
NRMRL National Risk Management Research Laboratory
OAQPS Office of Air Quality Planning and Standards
OEI Offcice of Environmental Information
OPP Office of Pesticide Programs
ORIA Office of Radiation and Indoor Air
ORCR Office of Resource Conservation and Recovery
OSCP Office of Science Coordination and Policy
OTAQ Office of Transportation and Air Quality
*Note: The percentages given after name represent the current percent of the total level of effort as documented in the EPA nomination.


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