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Health and Environmental Effects Research

NHEERL Scientists Participate in Workshop on Use of MOA To Support Development of Multipollutant Science Assessment for NAAQS Pollutants

Sections 108 and 109 of the Clean Air Act require periodic review and, if appropriate, revisions of the National Ambient Air Quality Standards (NAAQS). The NAAQS pollutants are carbon monoxide, lead, nitrogen dioxide, ozone, sulfur dioxide, and particle pollution. As part of the upcoming periodic review, the National Center for Environmental Assessment (NCEA) intends to develop a multipollutant assessment in which the health effects of exposure to mixtures of the NAAQS pollutants will be evaluated systematically. NCEA held a workshop in Research Triangle Park, NC, May 31, 2012, with invited EPA and external experts, as well as in-person and virtual audiences, to help define how mode-of-action (MOA) and toxicity-pathway data may be used to inform cumulative assessments of human health risks of mixtures of NAAQS pollutants. Several NHEERL experts served as session chairs, speakers, and panelists for the workshop. Aimen Farraj of NHEERL’s Environmental Public Health Division (EHPD) was a panelist for Session 1, Organizing Experimental Health Results Around Key Events for Biological Pathways Linked to Endpoints and Outcomes of Interest. Bob Devlin (EHPD) was co-chair of Session 2, Integrating Evidence from Epidemiologic Panel and Controlled Human Exposure Studies in an MOA Framework, and gave the plenary lecture. He also, along with Martha Carraway of EHPD, was a panelist for Session 2. Jane Ellen Simmons, NHEERL Integrated Systems Toxicology Division, was co-chair, plenary speaker, and panelist for Session 3, How Mixtures Have Been Evaluated in Other Media and by Other Groups. Other co-chairs, plenary speakers, and panelists included experts from NCEA; the California Environmental Protection Agency; the National Institute of Environmental Health Sciences; Procter and Gamble; Toxicology Excellence for Risk Assessment; the University of North Carolina at Chapel Hill; the University of New Mexico; the University of California, Davis; Harvard University; ToxStrategies, Inc.; and Gradient Environmental Consulting.

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