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Human Studies Divison
Clinical Research Branch
Human Studies Division Navigation
Robert Devlin, Chief
Download CV (PDF, 4 pp, 33 kb, About PDF)
The Clinical Research Branch has as primary goals to determine direct effects of pollutants on humans, to understand the basis by which pollutants exert their effects and understand the distribution, fate and kinetics of clearance of pollutants. Their primary functions include administering and monitoring exposures to human subjects under highly controlled laboratory settings and perform in vitro studies of human cells and tissues to investigate mechanisms by which pollutants exert their effects. CRB performs research using clinical in vitro approaches, including research at the functional physiological, cellular and molecular levels. CRB scientists measure the deposition, fate and biological effects of inhaled gases and particles on the pulmonary, cardiovascular, neurobehavioral, and immune systems and evaluate disposition and effects of contaminants on health.
The Human Studies Division complies with the requirements of the "Common Rule" to ensure that all human research involves short-term, real-world exposures conducted in a safe and ethical manner. Using state-of-the-art technology, human volunteers are exposed under controlled conditions to ambient concentrations of common environmental pollutants, such as:
- Air particles
- Ozone
- Hazardous air pollutants
- By-products from water disinfection
- Fuel additives
The health effects of these pollutants are then measured along a wide range of physiological parameters, including:
- Respiratory function
- Respiratory tract dosimetry
- Cardiovascular function
- Neurobehavioral effects
- Pharmacokinetics
- Cellular/molecular processes
- Immune status, including allergic response
Principal Investigators
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