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Pesticide News Story: Scientific Advisory Panel (SAP) Consultation on Advancing 21st Century Toxicology in Pesticide Risk Assessment

For Release: May 6, 2011

On May 24-26, 2011, there will be a 3-day consultation meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel to seek independent review on scientific issues related to using advanced computational and molecular tools to assess pesticides. EPA will present two case studies to illustrate principles of 21st century Integrated Approaches to Testing and Assessment.

One case study uses the antimicrobial triclosan to illustrate the use of information on an adverse outcome pathway – AOP is a descriptive tool that links a specific harmful effect to a direct initiating event that causes it at the molecular level – to inform the risk assessment and to identify susceptible populations. The other case study uses the fungicide propiconazole to illustrate the use of genomic information to assess an adverse outcome pathway. At this meeting, EPA will not be considering the overall risk assessment or proposing any regulatory action on triclosan or propiconazole but rather examining the application of new approaches to guide data generation in support of scientifically rigorous approaches to risk assessment in general.

As a supplement to the case study on triclosan, EPA is releasing an updated human exposure assessment for triclosan using the most current National Health and Nutrition Examination Survey data. Results of the SAP consultation combined with this latest exposure analysis will aid in the development of a revised human health assessment for triclosan. This will allow the Agency to be well prepared for initiating the registration review of triclosan in 2013 and for responding to the 2010 petition to ban triclosan from Beyond Pesticides and Food and Water Watch. Registration review is the comprehensive process EPA uses, on a 15-year cycle, to make sure pesticides continue to meet updated regulatory and scientific standards.

All documents for the SAP meeting (including additional background documents and public comments) will be available at www.regulations.gov in docket EPA-HQ-OPP-2011-0284.

Additional information also can be found on the Scientific Advisory Panel Web page in the Announcements box at: http://www.epa.gov/scipoly/sap/index.htm.

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