EPA Chemical Safety Research

Methods, Models, Tools, and Databases

Models

• Stochastic Human Exposure and Dose Simulation model for multimedia, multipathway chemicals (SHEDS-Multimedia)
  SHEDS-Multimedia is a physically-based, probabilistic model, that can simulate cumulative (multiple chemicals) or aggregate (single chemical) exposures over time for a population via residential and dietary routes of exposure for a variety of multimedia, multipathway environmental chemicals.
  Research question: How can you predict ranges of exposures in a population, identify important biological pathways and enhance dose estimates used to assess chemicals for potential risks?

Tools

• Probabilistic Reverse dOsimetry Estimating Exposure Distribution (PROcEED)
  PROcEED estimates unmeasured exposure concentration distributions from a population's measured biomarker concentrations
  Research question: What is the potential distribution of exposure concentrations likely to have produced the biomarker concentrations measured in a population?

• Ubertool: Ecological Risk Web Application for Pesticide Modeling
  Ubertool provides environmental models used to evaluate ecosystem-level pesticide risks. The dashboard infrastructure integrates the processing of model results for over a dozen commonly-used EPA aquatic and terrestrial regulatory models and supporting datasets.
  Research question: What are the risks of pesticides to the health of ecosystems?

Databases

• Aggregated Computational Toxicology Resource (ACToR)
  ACToR is an online warehouse of publicly availably chemical toxicity data from over 1,000 public sources on over 500,000 environmental chemicals.
  Research question: What public data is available to assess the toxicity of chemicals?
• ECOTOX
  ECOTOX summarizes in vivo toxicity of individual chemicals to aquatic and terrestrial organisms; to be incorporated into larger toxicology databases.
  Research question: How can I find data to help assess the toxicity of chemicals to aquatic life, terrestrial plants and wildlife?
• ExpoCast Database
  ExpoCast is a database with increasing data and functionality. Long term, the database will consolidate observational human exposure data and link to ToxRefDB, AcTOR and ToxCastDB to help make high throughput exposure predictions. Currently, the database contains consolidated observational human exposure data and improves access and linkages to health related data. Research question: How can knowledge of exposures inform risk-based decision making?
• Toxicity Forecaster (ToxCast)
  Provides chemical testing data for in vitro high throughput screening of 300 chemicals.  Data can be used to help prioritize chemicals and predict toxicity
  Research question: How can high-throughput screening data be used to predict potential toxicity, prioritize chemicals and inform chemical risk assessments?
• Toxicity Reference Database (ToxRefDB)
  ToxRefDB  contains thousands of animal toxicity studies on hundreds of  chemicals from 30 years worth of animal toxicity studies
  Research question: What animal toxicity data is available to help assess the toxicity of chemicals?

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