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Acceptable Substitutes in Refrigerated Transport

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Unacceptable substitutes     GWPs and ODPs of Some Refrigerants Used in Refrigerated Transport  

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Acceptable Substitutes for CFCs (class I ODS) in Refrigerated Transport

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HCFC-22   12, 502 R, N
Ikon A   12 R, N
Ikon B   12 R, N
THR-02   12 R, N
HFC-134a   12 R, N
R-401A, R-401B MP-39, MP-66 12 R, N
R-402A, R-402B HP-80, HP-81 502 R, N
R-404A HP-62 502, 12, 500 R, N
R-406A GHG 12, 500 R
R-407A, R-407B Klea 407A, 407B 502 R, N
R-408A (HCFC Blend Epsilon)   502 R
R-409A (HCFC Blend Gamma)   12 R
R-411A, R-411B   12, 500, 502 R, N
R-507 AZ-50 502 R, N
Free Zone (HCFC Blend Delta) Free Zone / RB-276 12 R, N
Freeze 12 Freeze 12 12 R, N
FRIGC FR-12 (HCFC Blend Beta) FRIGC FR-12 12, 500 R, N
GHG-X4 GHG-X4, Autofrost, Chill-it 12, 500 R, N
GHG-X5 GHG-X5 12, 500 R, N
GHG-HP (HCFC Blend Lambda) GHG-HP 12 R, N
G2018C G2018C 12, 500, 502 R, N
Hot Shot Hot Shot, Kar Kool 12, 500 R, N
HCFC-22/HCFC-142b   12 R, N
THR-04 THR-04 502 R, N
FOR12A FOR12A 12 R, N
FOR12B FOR12B 12 R, N
SP34E SP34E 12 R, N
HFC-134a/HBr (92/8)   12, 502 N
Direct Nitrogen Expansion   all N
Cryogenic Transport Refrigeration System Cryo-Mechanical 12, 502 N
Stirling Cycle   all N
Self-chilling cans using CO 2   12, 500, 502 N
RS-24 (2002 formulation)   12 R, N
NU-22 NU-22 502 R, N
R-407C Suva 407C, Klea 407C 502 R, N
R-421B Choice R421B 12, 502 R, N
R-426A RS-24 12 R, N
R-422C ICOR XLT1 502 R, N
R-428A RS-52 502 R, N
KDD6 KDD6 12 R, N
R-407D   12 R, N
Hot Shot 2   Hot Shot 2 12, 500, 502 R
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Refrigerated Transport

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
R-410A AZ-20, Suva 9100, Puron 22 and blends containing HCFCs N
R-410B   22, blends containing 22 and/or 142b N
THR-03   22 R, N
ISCEON 59, NU-22, R-417A ISCEON 59, NU-22 22, blends containing 22 and/or 142b R, N
R-407C Suva 9000, Klea 66 22 and blends containing HCFCs R, N
R-507, R-507A AZ-50 22 and blends containing HCFCs R, N
R-404A HP62 22 and blends containing HCFCs R, N
R-125/134a/600a (28.1/70.0/1.9) NU-22 old composition 22, blends containing 22 and/or 142b R, N
Self-Chilling cans using recycled CO2   22 R, N
RS-44 (2003 formulation)   22, blends containing 22 and/or 142b R, N
ISCEON 79, R-422A ISCEON 79 22 and blends containing HCFCs R, N
R-421A Choice R421A 22, blends containing 22 and/or 142b R, N
R-421B Choice R421B 22, blends containing 22 and/or 142b R, N
R-422D ISCEON MO29 22, blends containing 22 and/or 142b R, N
R-424A RS-44 22, blends containing 22 and/or 142b R, N
R-426A RS-24 22, blends containing 22 and/or 142b R, N
KDD5, R-438A ISCEON MO99 22, blends containing 22 and/or 142b R, N
R-434A RS-45 22, blends containing 22 and/or 142b R, N
R-428A RS-52 22 and blends containing HCFCs R, N
R-125/290/134a/600a (55.0/1.0/42.5/1.5) ICOR AT-22 22, blends containing 22 and/or 142b R, N
R-422B XAC1, NU-22B 22, blends containing 22 and/or 142b R, N
R-422C XLT1 22, blends containing 22 and/or 142b R, N
R-407A KLEA 60, KLEA 407A 22 and blends containing HCFCs R, N
HFC-134a   22, blends containing 22 and/or 142b R, N
RS-24 (2002 formulation)   22, blends containing 22 and/or 142b R, N
R-407D   22, blends containing 22 and/or 142b R, N
R-407B   22, blends containing 22 and/or 142b R, N
Cryogenic system using recaptured liquid CO2 or liquid nitrogen   22, blends containing 22 and/or 142b N
Direct nitrogen expansion   22, blends containing 22 and/or 142b N
SP34E SP34E 22, blends containing 22 and/or 142b R, N
Stirling cycle   22, blends containing 22 and/or 142b N
Hot Shot 2  Hot Shot 2 22, blends containing 22 and/or 142b R
R-407F    Genetron Performax LT 22, blends containing 22 and/or 142b R, N
Key: R = Retrofit Uses, N = New Uses

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