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Cumulative Risk Assessment Methods and Tools

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Cumulative risk is the risk of a common toxic effect associated with concurrent exposure by all relevant pathways and routes of exposure to a group of chemicals that share a common mechanism of toxicity.

Guidance Documents

Exposure Assessment Models

Three models are in common use in EPA's Office of Pesticide Programs. These are: (1) DEEM (Dietary Exposure Evaluation Model)/Calendex, (2) Lifeline, and (3) CARES (Cumulative and Aggregate Risk Evaluation System). Each of these models uses food and drinking water consumption data from USDA's Continuing Survey of Food Intake by Individuals (CSFII 1994-96, 1998) and user-entered residue data to estimate dietary exposure using probabilistic techniques. Each of these three models also has the capability of performing residential exposure assessments and appropriately aggregating exposures across multiple pathways and routes.

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