Figure segment from Kleinstreuer, et al. 2014
EPA scientists recently published a paper on high throughput toxicology research in Nature Biotechnology that showcased how ToxCast might be used to predict the potential toxicity of chemicals. EPA researchers analyzed the screening results generated by one of its assay technologies, BioSeek, and compared the results to known chemical information to determine if this new technology can be used to predict the potential toxicity and therapeutic effect of 776 chemicals found in pharmaceuticals, pesticides, and other commonly used consumer products.
The paper describes the analysis of all screening results and then compares them to animal toxicity studies and other established toxicity information, demonstrating that these new technologies can be used to predict potential health hazards. The authors also explain that the screening results provide information on how the chemicals interact with exposed cells and which important biological processes may be impacted.