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Chemical Safety Research Update

August 2014 Research Highlights

The CSS August 2014 research update includes the following highlights:

Archived Research Updates
CSS Highlights

EPA Paper Published in Nature Biotechnology: Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

EPA scientists recently published a paper on high throughput toxicology research in Nature Biotechnology that showcased how ToxCast might be used to predict the potential toxicity of chemicals. EPA researchers analyzed the screening results generated by one of its assay technologies, BioSeek, and compared the results to known chemical information to determine if this new technology can be used to predict the potential toxicity and therapeutic effect of 776 chemicals found in pharmaceuticals, pesticides, and other commonly used consumer products.

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EPA Paper Awarded “Top Five Best Papers” in SETAC Journal 2013

EPA researcher Carlie LaLone’s paper titled, Cross species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone has been awarded “Best Paper Award Finalist” by the Society of Environmental Toxicology and Chemistry (SETAC) for 2013. This paper was among 5 nominated articles for “Best Paper Award.”

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Non-Monotonic Dose Response Curve (NMDRC)

The National Academy of Sciences released their review of EPA’s State-of-the-Science Evaluation of Nonmonotonic Dose–Response Relationships as They Apply to Endocrine Disruptors. This report is the Agency’s first step towards an evaluation of the state of the science and informed understanding of NMDRs and their implications to chemical testing strategies.

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CSS Program in Review

Joint Science Advisory Board (SAB) and Board of Scientific Counselors (BOSC) Meeting -- July 24-25

The SAB and BOSC met July 24-25 to evaluate preliminary outlines of EPA’s Office of Research and Development’s (ORD) FY16-19 Strategic Research Action Plans (StRAPs) for the National Research Programs (NRPs). The six research programs (ACE, CSS, SSWR, HHRA, HS, and SHC) provided overviews of their strategic direction, soliciting feedback from the SAB and BOSC advisory members.

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FIFRA Scientific Advisory Panel Meeting -- July 29-30

The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel (SAP) met July 29-30, 2014 to hear presentations from EPA researchers about using high-throughput exposure estimates to prioritize chemicals for potential endocrine disruption. The SAP was convened by EPA’s Endocrine Disruption Screening Program (EDSP).

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Upcoming Events & Meeting Announcements

ToxCast Data Summit -- September 29-30 at EPA in Research Triangle Park, NC

Do you have ideas of how the ToxCast high-throughput screening data can be used? We want YOU to submit your ideas in an abstract for this event! It is not necessary to have any detailed or published work in order to attend.

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EPA @ Upcoming International Society of Exposure Science (ISES) Meeting

The EPA will be participating in the 24th Annual International Society of Exposure Science (ISES) Meeting coming up on October 12-16, 2014 in Cincinnati, Ohio. The theme for this year is Exposure Science Integration to Protect Ecological Systems, Human Well-Being, and Occupational Health, with the Agency’s own Dr. Tim Buckley and Dr. Lisa Jo Melnyk serving as meeting chairs.

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EPA Scientists to Present at 9th World Congress on Alternatives and Animal Use in the Life Sciences Meeting -- August 24-28 in Prague, Czech Republic

Dr. Bob Kavlock, Deputy Assistant Administrator for Science of the Office of Research and Development, is a Keynote Speaker at the 2014 WC9 meeting. He will be discussing the US Program Toxicology in the 21st Century (Tox21), which is a federal collaboration between EPA, NIEHS/NTP, NCATS, and FDA.

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AOP Scientific Workshop -- September 3-5, 2014

The National Toxicology Program (NTP) and Physicians Committee for Responsible Medicine (PCRM) are hosting a public scientific workshop, Adverse Outcome Pathways: From Research to Regulation, on September 3-5, 2014 in Bethesda, MD.

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Previous Events & Meetings

EPA Hosts Networks for Characterizing Chemical Life Cycle (NCCLC) and Networks for Sustainable Molecular Design and Synthesis (NSMDS) Grantees Kick-Off Meeting

On June 23-24, 2014, EPA hosted a kick-off meeting for grants recently awarded to academic institutions to form two research networks: the Networks for Characterizing Chemical Life Cycle (NCCLC) and the Networks for Sustainable Molecular Design and Synthesis (NSMDS). These grants were funded through a joint collaboration between EPA and the National Science Foundation.

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Green Chemistry & Engineering Conference

EPA had a large presence at the American Chemical Society (ACS) Green Chemistry Institute’s 18th Annual Green Chemistry and Engineering Conference on June 17-19, 2014. CSS National Program Director (NPD) Dr. Tina Bahadori served as one of the co-chairs on the conference organizing committee, along with Deputy NPD Dr. Elaine Cohen Hubal who chaired one of the Chemical Design sessions, titled "Knowledge and Tools to Evaluate Alternatives."

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International OECD meeting for Validating Testing Standards for Engineered Nanoparticles

Dr. William K. Boyes participated in the Organization for Economic Cooperative Development (OECD) Working Party on Manufactured Nanoparticles June 4-5 meeting. At the meeting, two sub-committees: the Steering Group on Testing and Assessment of Manufactured Nanomaterials (SG-TA) and the Steering Group on Risk Assessment and Regulatory Programs (SG-AP) met to discuss approaches for validating testing standards for engineered nanomaterials.

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Funding & Employment Opportunities

EPA is Accepting Applications for ORISE Postdoctoral Positions

As part of the Oak Ridge Institute for Science and Education (ORISE) Internship/Research Positions Program, EPA is accepting applications for a number of Chemical Safety for Sustainability (CSS) centric positions across several EPA labs and centers including: the National Health Effects Research Lab (NHEERL), the National Exposure Research Lab (NERL), the National Center for Environmental Assessment (NCEA), the National Risk Management Research Lab (NRMRL), and the National Center for Computational Toxicology (NCCT).

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Chemical Safety Research in the News

Subscribe for Chemical Safety Research Updates

Thank you for reading the Chemical Safety for Sustainability Research News and Highlights, August issue. If you do not regularly receive our quarterly updates and would like to be added to the distribution listserv, please let us know by contacting LaCresha Styles (styles.lacresha@epa.gov).

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Visit EPA's Chemical Safety Web Page Regularly for Updates

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