The AOP Framework
On September 25th, through a collaboration with the international scientific community, the European Joint Research Center, the US Army Corp of Engineers and the Organization for Economic Cooperation and Development (OECD), EPA publicly released the online Adverse Outcome Pathway (AOP) Wiki—an interactive, virtual encyclopedia for global AOP development and evaluation. An AOP is a conceptual framework that shows existing knowledge concerning the linkage between a chemical interacting with a biological process, a direct molecular initiating event, and an adverse human or environmental health risk. The wiki is the first publicly released module of the larger AOP Knowledgebase (AOP KB). This close international collaboration has resulted in the beginnings of a knowledgebase that will consolidate comprehensive knowledge on how chemicals can induce adverse effects.