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National Advisory Council for Environmental Policy and Technology (NACEPT)
Endocrine Disruptor Methods Validation Subcommittee (EDMVS)
Third Plenary Meeting - March 25-27, 2002
DRAFT Agenda
RESOLVE
1255 23rd Street, N.W., Suite 275
Washington, DC 20037
(202) 944-2300
Members of the public may join this conference call in person at the conference room in the RESOLVE offices at 1255 23rd St. NW, Suite 275, Washington, DC. To register to participate by phone, please contact Jane Smith, designated federal official for the EDMVS, at smith.jane-scott@epa.gov or (202) 564-8476. Also note that members of the public who would like to make comments during the conference call need to contact Ms. Smith prior to the
Meeting Objectives
- Understand the practical aspects of the implementation of the validation process by the Endocrine Disruptor Screening Program (EDSP).
- Provide comments and advice on:
- The suite of chemicals used in prevalidation of EDSP-related assays;
- The fish reproduction assay detailed review paper;
- Special studies on fathead minnow assays, vitellogenin assay, and avian dosing protocol;
- The aromatase detailed review paper;
- The in utero through lactation assay protocol.
- Understand sources of data used in assessing human health effects.
- Understand EPA's approach to addressing low dose issues.
Monday, March 25, 2002
1:00 - 1:10 Welcome and Opening Comments
Dr. Vanessa Vu, EDMVS Chair and Director, Office of Science
Coordination and Policy (OSCP), EPA
Dr. William Benson, EDMVS Vice-Chair, Office of Research and Development
(ORD), EPA
1:10 - 1:30 Introduction, Agenda Review, and Review of Previous Meeting Summary
Paul De Morgan, Facilitator, RESOLVE
1:30 - 2:00 Review of EDMVS Work Plan
Jane Smith, EDMVS Designated Federal Official, OSCP, EPA
2:00 - 3:00 Practical Aspects of the Implementation of the Validation Process by the EDSP
Gary Timm, OSCP, EPA
3:00 - 3:15 Break
3:15 - 3:45 Chemicals Used in Prevalidation of EDSP-related Assays
Jim Kariya, OSCP, EPA
3:45 -4:15 Overview of Ecotoxicological Assays
Dr. Les Touart, OSCP, EPA
4:15 - 5:00 Special Study: Tier 2 Avian Dosing Study
Dr. Les Touart, OSCP, EPA
5:00 - 5:30 Public Comment
Members of the public will be given an opportunity to comment on any aspect of the EDMVS work. The amount of time given to each individual will depend on the number of people wishing to provide comment.
5:30 - 5:45 Setting the Stage for Day Two
5:45 Adjourn for the day
Tuesday, March 26, 2002
9:00 - 9:15 Settling In
9:15 - 10:45 Short-Term Fish Reproduction Assay and Discussion of the Fish Screening Assays Detailed Review Paper
Dr. Les Touart, OSCP, EPA
Dr. Gary Ankley, Midcontinent Ecology Division, National Health and Environmental
Effects Research Laboratory (NHEERL), ORD, EPA
10:45 - 11:00 Break
11:00 - 11:45 Special Study: Comparative Evaluation of Fathead Minnow Assays
Dr. Les Touart, OSCP, EPA
11:45 - 1:00 Lunch
1:00 - 1:45 Special Study: Comparative Evaluation of Vitellogenin Methods
Dr. Les Touart, OSCP, EPA
1:45 - 2:30 Discussion of Core Chemicals Used in Prevalidation of EDSPrelated Assays
Jim Kariya, OSCP, EPA
2:30 - 3:00 Sources of Data Used in Assessing Human Health Effects
Dr. Vanessa Vu, Director, OSCP, EPA
3:00 - 3:15 Break
3:15 - 3:45 EPA's Approach to Addressing Low Dose Issues
Dr. Vanessa Vu, Director, OSCP, EPA
3:45 - 4:15 Public Comment
Members of the public will be given an opportunity to comment on any aspect of the EDMVS work. The amount of time given to each individual will depend on the number of people wishing to provide comment.
4:15 - 4:30 Setting the Stage for Day Three
4:30 Adjourn for the day
Wednesday, March 27, 2002
9:00 - 9:15 Settling In
9:15 - 10:45 Aromatase Detailed Review Paper
Dr. Susan Laws, Reproductive Toxicology Division, NHEERL, ORD, EPA
10:45 - 11:00 Break
11:00 - 12:00 In Utero Through Lactation Protocol
Gary Timm, OSCP, EPA
Dr. Earl Gray, ORD, EPA
12:00 - 12:45 Next Steps and Agenda for Fourth Meeting
12:45 Adjourn