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Basic Course: Supplemental Topics

Risk Assessment for Cancer Effects (Linear): Other Terms in the Equation

The remaining terms in the equation for deriving linear cancer human health AWQC are consistent across all three equations.

Equation: AWQC = RSD x open bracket BW divided by DI + summation of 4 over i=2 (FLi x BAFi) close bracket.

Exposure

BW = Human Body Weight (70 kg for average adult)
DI = Drinking Water Intake (2 L/day for average adult)
FI = Fish Intake (kg/day)

Bioaccumulation

BAF = Bioaccumulation Factor (L/kg)

Note that details about exposure and bioaccumulation terms are presented later in this module, following this section that focuses on the three equations used to calculate human health AWQC.

Key Point. Remember the RSD term in the equation is the risk you select (10-6 or 10-5, as long as the exposed population risk is not greater then
10-4) divided by the cancer slope factor. IRIS is the best source of CSF data for chemical contaminants.

Disclaimer:
For informational purposes only–Not official statements of EPA policy.

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