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Basic Course: Supplemental Topics

Risk Assessment for Cancer Effects (Nonlinear): Other Terms in the Equation

The remaining terms in the equation for deriving nonlinear cancer human health AWQC are consistent across all three equations, except for RSC, which is also used in the equation for noncancer effects but not in the equation for linear cancer effects.

Formula: AWQC = POD divided by UF x RSC x open bracket BW divided by DI + summation of 4 over i=2 (FLi x BAFi) close bracket.

Exposure

RSC = Relative Source Contribution (%, to account for other sources of exposure).
BW = Human Body Weight (70 kg for average adult).
DI = Drinking Water Intake (2 L/day for average adult).
FI = Fish Intake (kg/day).

Bioaccumulation

BAF = Bioaccumulation Factor (L/kg).

Note that details about exposure and bioaccumulation terms are presented in the next section of this module.

Disclaimer:
For informational purposes only–Not official statements of EPA policy.

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