Society of Toxicology (SOT) 2025 Conference

Given recent travel restrictions, EPA staff are not participating in SOT in person. Please check below for EPA SOT Posters and check the SOT app as many of EPA's presentations will be available virtually.

EPA Research at SOT | 2025

• EPA SOT Posters
• SOT Overview
• Exhibit Booth Resources

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EPA SOT Posters 

While EPA presenters weren't able to participate in the meeting, below are the posters that were planned to be presented! Additional posters added 4/21/2025. 

EPA Affiliated Author*	Poster Title
Barbo, Nadia	Development of an In Vitro Natural Killer Cell-Mediated Cytotoxicity Assay Using the NK-92 Cell Line
Breaux, Kristen	Screening for Androgen Disruption in an Androgen Receptor Dimerization Assay with Metabolic Competence
Buglewicz, Dylan	Evaluating PFOA-Transthyretin Interactions Using Molecular Dynamic Simulation to Enhance Conservation Analysis for Cross Species Extrapolation
Byrd, Gabrielle	A High-Throughput Phenotypic Profiling Screen of the LOPAC®1280 Library of Pharmacologically Active Compounds in Human Neural Progenitor Cells
Caty, Stephanie	Application of a high-content imaging strategy for detecting developmental immunotoxicity in transgenic zebrafish larvae
Carstens, Kelly	A Machine Learning Approach for Developmental Neurotoxicity: Promise and Limitations of Integrating Multi-dimensional In Vitro Data Streams
Carstens, Kelly	New approach methods for evaluation of developmental neurotoxicity: fit-for-purpose analysis approaches in a multi-dimensional data landscape
Ceger, Patricia	Towards Increased Data Interoperability and Reuse: Applying Literature Review Data to the Adverse Outcome Pathway Framework
Cogbill, Rachael	Modelling distribution of PFAS into tissues: Comparing partition coefficient estimates from a standard, logP-based approach to a PFAS-specific model designed to address inadequacy of lipophilicity-based models.
Corton, Chris	Characterization of a Hypoxia-inducible Factor-1 Gene Expression Biomarker
D'Angelo, Brendan	Novel Co-Factor Recruitment Assay Identifies Estrogen Disrupting Chemicals
Deisenroth, Chad	Screening for Androgen Disruption in an Androgen Receptor Dimerization Assay with Metabolic Competence
Deisenroth, Chad	Orthogonal Screening of Prioritized PFAS for Mechanistic and Functional Effects using Thyroid New Approach Methods
Edwards, Stephen	Introduction to Knowledgebases
Everett, Logan	An analytical framework to optimize transcriptomic dose-response modeling for use in regulatory assessments
Haggard, Derik	Software Pipeline Development for High-throughput Tier 1 Chemical Screening Assays
Harrill, Alison	Development of new EPA human health assessment products using (1) transcriptomics and (2) published in vivo studies
Harrill, Alison	Toward setting appropriate performance benchmarks for toxicology NAMs data
Harrill, Josh	Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes
Harrill, Josh	Is It Possible to Model Lifestyle Factors? Examples of Modeling Physiological Stress In Vitro
Hughes, Michael	Immunotoxic assessment of four per- and polyfluoroalkyl substances following 28-day oral repeat dosing in rats evaluated by the anti-sheep red blood cell IgM response
Inan, Kahn	Identifying Molecular Targets with Cell-Line Specific Sensitivity to Chemical Perturbation in High Throughput Transcriptomics
Isaacs, Kristin	The Chemicals and Products Database and the Chemical Exposure Knowledgebase Organizing and Disseminating Chemical-Use Data for Informing Exposure Pathways
Johnson, James	In vitro transcriptional points of departure from human whole transcriptome and reduced transcriptome (S1500+) targeted RNA-Seq assays are highly comparable
Jurgelewicz, Amanda	Assessing the Impact of In Vitro Metabolism on Estrogenic Chemical Bioactivity in High-Throughput Profiling Assays
Kenyon, Elaina	Systemic subchronic toxicity and comparison of four per- and polyfluoroalkyl substances (PFAS) by oral exposure in Sprague-Dawley rats
Ko, Ashley	Generating GD211-Aligned Documentation for ToxCast to Support Assay Interpretation and Data Use
Kruse, Paul	ctxR An R package for accessing the CTX APIs
Kruse, Paul	ctxR: Utilities for interacting with the CTX APIs
LaLone, Carlie	Enhanced Species Extrapolation with Protein Structural Comparisons using SeqAPASS
Lea, Isabel	Integrated Computational Approaches in Systematic Evidence Mapping: Bridging Human Expertise and Machine Learning for Advanced Toxicological Assessments
Lew, Dane	Biotransformation of 6:2 Fluorotelomer Alcohol by Rainbow Trout, Rat, and Frog Liver Assays
Martin, Rubia	Toxicological Effects of Several Real-Word PFAS Mixtures on U2OS Cells and Zebrafish
Mayil Vahanan, Manasvinee	A data-driven approach to detect developmental neurotoxicity in the time-course of a microelectrode array neural network formation assay
Mutlu, Esra	Implementation of the New EPA Transcriptomics Assessment Product (ETAP) for Data Poor Chemicals
Nash, Mackenzie	Transcriptomic Points of Departure from Whole vs Targeted Transcriptome Sequencing
Padilla Mercado, Gilberto	Leveraging in vivo and in vitro data to estimate modes of metabolic clearance
Paul Friedman, Katie	Integration of New Approach Methods for the Assessment of Data Poor Chemicals
Paul Friedman, Katie	Quantifying the Reproducibility and Variability of In Vivo Guideline Toxicology Studies
Phelps, Drake	Development of a High-Throughput In Vitro Chemotaxis Assay in Jurkat T Cells for Hazard Identification of Immunotoxicants
Phillips, Allison	Selection of the Most Suitable Source Analogue for 2,3-Benzofluorene Using Read-Across Methodology to Support Derivation of Human Health Toxicity Values
Ring, Caroline	ExpoCast: accessible computational tools for informing exposure
Rogers, Jesse	Integrating High-Throughput Omics to Predict Targeted Bioactivity from Chemical Screening Data
Sadrpour, Parisa	Evaluation of Alternative High Throughput Screening Assays for the Estrogen Receptor Computational Model to Support the Endocrine Disruption Screening Program
Scherer, Meredith	Modeling in vitro distribution improves accuracy of bioavailable dose estimation.
Shafer, Timothy	Leveraging the Developmental Neurotoxicity In Vitro Battery to Contextualize In Vivo Apical Observations
Simmons, Steve	Comparative Cytotoxicity of Disinfection Byproducts using a High-throughput Protocol
Sink, Warren	2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently disrupts hepatic thyroid hormone signaling in mice
Sterner, Teresa	Rapid risk assessment of potential neurotoxicants using non-animal test methods
Sumner, Catherine	Quantifying In Vitro Disposition of Per- and Polyfluoroalkyl Substances (PFAS) Using Human Breast Cancer (MCF7) and Osteosarcoma (U-2 OS) Cell Lines
Tabatabaei Sadeghi, Sahar	Evaluation of Machine Learning-Based NAM Models for Key HTTK Parameters in Toxicokinetics
Thomson, Colin	The Effects of Life-stage Variability in High-throughput Toxicokinetic Simulations
Truong, Kimberly	Interpretation of thyroid-relevant bioactivity data for comparison to in vivo exposures
Wall, Taylor	Development of the Toxicity Values Database, ToxValDB: A Curated Resource for Experimental and Derived Human Health-Relevant Toxicity Data
Walsh, Jennifer	Development and Characterization of In Vitro Blood-brain Barrier Models to Screen Environmental Chemicals for Neurotoxicity
Wambaugh, John	Synergies between Approaches for High-Throughput Quantitative In Vitro to In Vivo Extrapolation
Wambaugh, John	IVIVE Approaches for Semi-volatile and Volatile Chemicals
Wehmas, Leah	Application and advancement of the EPA transcriptomic assessment product (ETAP) to support rapid risk assessment of data poor chemicals
Weitekamp, Chelsea	Quantitative and Qualitative Concordance Between Clinical and Nonclinical Toxicity Data
Willis, Clinton	Surveying the Biological Activity of Drugs and Consumer Product Chemicals Across Ten Biologically Diverse Human-Derived Cell Lines using the Cell Painting Assay
Yoon, Miyoung	Systematic Evidence Mapping of the Use of NAM data and Quantitative In Vitro to In Vivo Extrapolation for Chemical Risk Assessment: A Case Example using 4-Nonylphenol
Zurek-Ost, Michael	Integrating network analysis of historical targeted and emerging non-targeted concentration data with population and environmental indicators for intelligent sampling design

(*Can be federal or non-federal presenter)

Overview

EPA scientists are virtually participating in the 2025 Society of Toxicology (SOT) Annual Meeting and ToxExpo from March 15-20 in Orlando, FL. Advances in EPA's toxicology research will be featured at SOT sessions, symposia, workshops, platform discussions, informational sessions, poster sessions, and at EPA's booth. SOT provides a forum to discuss and disseminate information about this research to the scientific community. 

EPA scientists serve in leadership roles in SOT such as officers and chairpersons, leading and participating in continuing education courses and providing scientific presentations during plenary sessions as keynote speakers. 

Exhibit Booth Resources

• Research Programs and Centers
• Regional Science Program
• Research and Technology Development Opportunities

Student and Fellowship Opportunities

• Career Opportunities at EPA

Research Area Webpages

• EPA Research
  • Air Research
  • Safer Chemicals Research
  • Ecosystems Research
  • Health Research
  • Homeland Security Research
  • Human Health Risk Assessment Research
  • Land and Waste Management Research
  • Water Research